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010   $a94-024-0962-9
024 7 $a10.1007/978-94-024-0962-8
035   $a(CKB)3710000000953326
035   $a(DE-He213)978-94-024-0962-8
035   $a(MiAaPQ)EBC4745431
035   $a(PPN)197134750
035   $a(EXLCZ)993710000000953326
100   $a20161117d2016      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aSirtuins /$fedited by Riekelt H. Houtkooper
205   $a1st ed. 2016.
210  1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2016.
215   $a1 online resource (VIII, 288 p. 30 illus., 24 illus. in color.) 
225 1 $aProteins and Cell Regulation ;$v10
311   $a94-024-0961-0 
327   $aGeneral introduction, Riekelt H. Houtkooper -- Biochemistry and Enzymology of Sirtuins, Yue Yang and Anthony A. Sauve -- NAD+ as a pharmacological tool to boost sirtuin activity, Riekelt H. Houtkooper -- Protein lysine acylation: abundance, dynamics and function, Olga Pougovkina and Vincent C. J. de Boer -- SIRT1 in metabolic health and disease, Marie Boutant and Carles Cantó -- Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function, Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell, Brett S. Peterson, Laura A. Starzenski, Donald S. Backos, Kristofer S. Fritz, and Matthew D. Hirschey -- SIRT5 reveals novel enzymatic activities of sirtuins, Bin He and Hening Lin -- Diverse roles for SIRT6 in mammalian healthspan and longevity, Bernadette M. M. Zwaans, William Giblin and David B. Lombard -- Sirtuins in cancer ? emerging role as modulators of metabolic reprogramming, Jaewon J. Lee, Karina N. Gonzalez Herrera and Marcia C. Haigis -- Sirtuins as metabolic modulators of muscle plasticity, Keir Menzies, Julien Francisco Zaldivar-Jolissaint and Johan Auwerx -- Sirtuins and aging, Carles Cantó and Riekelt Houtkooper -- Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk, Selma Masri, Marina Maria Bellet and Paolo Sassone-Corsi -- Sirtuin activation by small molecules, Hassina Massudi, Lindsay E. Wu, and David A. Sinclair -- Future perspective, Brian Kennedy -- Index.
330   $aThe sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.
410  0$aProteins and Cell Regulation ;$v10
606   $aCancer research
606   $aMetabolic diseases
606   $aDiabetes
606   $aMolecular biology
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aMetabolic Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33118
606   $aDiabetes$3https://scigraph.springernature.com/ontologies/product-market-codes/H33045
606   $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
615  0$aCancer research.
615  0$aMetabolic diseases.
615  0$aDiabetes.
615  0$aMolecular biology.
615 14$aCancer Research.
615 24$aMetabolic Diseases.
615 24$aDiabetes.
615 24$aMolecular Medicine.
676   $a614.5999
702   $aHoutkooper$b Riekelt H$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910151785603321
996   $aSirtuins$92532309
997   $aUNINA