LEADER 02684nam 2200469 450 001 9910149708703321 005 20230810000035.0 010 $a981-4759-47-3 035 $a(CKB)2660000000040941 035 $a(MiAaPQ)EBC4731795 035 $a(WSP)00009966 035 $a(EXLCZ)992660000000040941 100 $a20160616h20172017 uy| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aUnravelling complexities in genetics and genomics $eimpact on diagnosis counseling and management /$fMoyra Smith 210 1$aNew Jersey :$cWorld Scientific,$d[2017] 210 4$dİ2017 215 $a1 online resource (430 pages) $ccolor illustrations 300 $aTitle from PDF file title page (viewed October 10, 2016). 311 $a981-4759-46-5 320 $aIncludes bibliographical references and index. 327 $aExpanding insights into genes and expression -- Genomic integrity and relevance to disease -- Epigenetics and epigenomics -- Proteins, proteomics, protein folding and proteostasis -- Genotype-phenotype correlations and complexities -- Immune system -- Lipids, atherosclerosis, metabolic syndromes and diabetes -- Early-onset neurocognitive and neurobehavioral disorders -- Integrating advances in neurobiology and genetics into psychiatry -- Neurodegenerative diseases -- Cancer. 330 $a"Reviews recent advances in defining genetic and genomic factors that play important roles in diseases in humans. It includes discussions on new technologies in DNA and RNA sequencing, genome analysis, and bioinformatics applied to the study of patients with specific disorders and to normal populations, and illustrates how modern molecular techniques can improve diagnoses and enable the design of specific targeted therapies and methods of prevention. Additional emphasis is placed on the genetic variants and genomic risk factors related to the development of complex common disorders, including neurobehavioral and neurocognitive disorders in children and adults and late onset disorders in adults, including atherosclerosis, type 2 diabetes, cancer, and neurodegenerative disorders."--Publisher's website. 606 $aGenomics 606 $aGenetic counseling 606 $aDisease management 615 0$aGenomics. 615 0$aGenetic counseling. 615 0$aDisease management. 676 $a572.8/6 700 $aSmith$b Moyra$01130727 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910149708703321 996 $aUnravelling complexities in genetics and genomics$92889548 997 $aUNINA