LEADER 04206nam 2200673 450 001 9910136793403321 005 20230621140122.0 035 $a(CKB)3710000000631052 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40269 035 $a(EXLCZ)993710000000631052 100 $a20160411d2016 fy| 0 101 0 $aeng 135 $aurmu#---uuuuu 181 $ctxt$2rdacontent 182 $cc$2rdamedia 182 $ccr$2rdacarrier. 183 $acr$2rdacarrier 200 00$aAdvances in epithelial ovarian cancer$b[electronic resource] $emodel systems, microenvironmental influences, therapy, and origins /$fedited by Viive Maarike Howell, Ben Davidson, Tian-Li Wang and Christina Annunziata 210 $cFrontiers Media SA$d2016 210 1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d2016. 210 4$d©2016 215 $a1 online resource (176 pages) $cillustrations; digital, PDF file(s) 225 1 $aFrontiers Research Topics 225 1 $aFrontiers in oncology 311 $a2-88919-769-7 320 $aa Includes bibliographical references. 330 3 $aThis eBook provides a compendium of the current state-of-the-art in research tools for, and understanding of, the critical research areas in epithelial ovarian cancer (EOC) with a strong emphasis on (HG-SOC). Research areas covered include therapy response and development, microenvironmental influences and the etiology and progression of EOC. Ten articles detail established and novel in vivo and in vitro model systems. These include primary and immortalized cell culture in 2D and 3D as well as genetically engineered, transgenic, spontaneous, syngeneic, classical xenograft and patient derived xenograft mouse models. The generation of genetically engineered mouse models of HG-SOC has been a major dilemma as models with the oncogenic aberrations common in the human malignancy do not accurately recapitulate HG-SOC. Conversely, commonly used HG-SOC cell lines have been found to not harbor the expected genetic changes. These issues as well as the rapid acceptance of patient derived xenograft models are reviewed. Five articles discuss different aspects of the tumor microenvironment including its role in therapy resistance, disease progression and metastasis. Mutation of BRCA1/2 continues to be the best defined risk factor for HG-SOC. Three articles discuss BRCA-loss in the context of disease development, targeted therapies and changes in preventative measures proposed for mutation carriers in light of the recent advances in knowledge regarding the origins of this malignancy. An image of HG-SOC with reduced BRCA1 expression is featured on the cover (image by VM Howell). A major clinical issue for patients with HG-SOC is the development of therapy resistance. Five articles focus on therapy resistance and different ways to overcome resistance. Overall, this eBook is an outstanding resource to aid researchers design their programs of research and determine the most appropriate and up-to-date EOC model systems to address their research questions. 410 0$aFrontiers in oncology. 410 0$aFrontiers research topics. 606 $aOvaries$xCancer$xResearch 606 $aNeoplasms 606 $aOncology 610 $a3D-cell culture 610 $aOvarian cancer stem cells 610 $aovarian cancer 610 $atumor-associated macrophage 610 $aBRCA 610 $achemoresistance 610 $afallopian tube 610 $atumour microenvironment 610 $amouse models of ovarian cancer 610 $apatient derived xenografts 610 $aprimary ovarian tumour cells 610 $aAscites 615 0$aOvaries$xCancer$xResearch. 615 0$aNeoplasms. 615 0$aOncology. 676 $a616.99465 700 $aBen Davidson$4auth$01366916 702 $aHowell$b Viive Maarike 702 $aDavidson$b Ben$cM.D., 702 $aWang$b Tian-Li 702 $aAnnunziata$b C$g(Christina) 712 02$aFrontiers Research Foundation, 801 2$bUkMaJRU 906 $aBOOK 912 $a9910136793403321 996 $aAdvances in epithelial ovarian cancer$93389440 997 $aUNINA LEADER 04057oam 2200733 c 450 001 9910149633003321 005 20251102090541.0 010 $a3-7639-1799-3 024 3 $a9783763917990 035 $a(CKB)2560000000060073 035 $a(EBL)647015 035 $a(OCoLC)705535909 035 $a(SSID)ssj0001586003 035 $a(PQKBManifestationID)16266665 035 $a(PQKBTitleCode)TC0001586003 035 $a(PQKBWorkID)14866701 035 $a(PQKB)10368457 035 $a(MiAaPQ)EBC647015 035 $a(wbv Publikation)9783763917990 035 $a(EXLCZ)992560000000060073 100 $a20251102d2010 uy 0 101 0 $ager 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSouverän Seminare leiten /$fWolf-Peter Szepansky 205 $a2nd ed. 210 $aBielefeld$cwbv Publikation$d2010 215 $a1 online resource (173 p.) 225 0 $aPerspektive Praxis 300 $aDescription based upon print version of record. 311 08$a3-7639-1798-5 327 $a1 Einleitung 2 Den Start meistern 2.1 Konventionen und Struktur 2.2 Kleingruppen bilden 2.3 Übertragungen und Projektionen 2.4 Autorität stärken 2.5 Peinliche Situationen 2.6 Schweigen 3 Motivation erzeugen 3.1 Bedingungen für motiviertes Lernen 3.2 Spannend ins Thema einsteigen 3.3 Methodenvielfalt bei der Wissensvermittlung 4 Provokationen begegnen 4.1 Der Konflikt 4.2 Lösungsstrategien 5 Neue Gruppenmitglieder integrieren 5.1 Der Konflikt 5.2 Lösungsstrategien 6 Dilemma-Situationen auflösen 6.1 Der Konflikt 6.2 Lösungsstrategien 7 Störer eingliedern 7.1 Der Konflikt 7.2 Lösungsstrategien 8 Widerstand als Signal verstehen 8.1 Der Konflikt 8.2 Lösungsstrategien 9 Den Schluss gestalten 9.1 Abschiednehmen: ein individuelles Muster 9.2 Abschlussrituale 9.3 Umgang mit Kritik 330 $aSeminare leiten macht Spaß. Oft genug aber bergen Lehr-Lernsituationen Konfliktpotential. Das vorliegende Buch rückt diese, insbesondere die Lehrenden herausfordernden, Situationen ins Blickfeld. Anhand von konkreten Praxisbeispielen werden Handlungsalternativen abgewogen und Hilfen zum souveränen Agieren gegeben. Dabei wird in knapper Form auch das nötige Hintergrundwissen zu Gruppenprozessen vermittelt. Das Buch ist aufgrund seiner Praxisnähe auch für erfahrene Lehrende in der Erwachsenenbildung anregend. Neu in dieser Auflage ist ein zusätzliches Kapitel zur Lernmotivation. Alle Checklisten und Handouts können kostenlos im Internet heruntergeladen werden. Running seminars is fun. Some learning groups can, however, carry potential conflicts. This book focuses on such conflict situations that can become critical for lecturers and trainers. Using six typical example situations, alternative courses of action are evaluated and advice is given on how to act with confidence. The necessary background knowledge to group processes is added in concise form. As the book is written with great honesty and much practical relevance, it will motivate even experienced adult educators. This edition has an additional chapter on learning motivation. All checklists and hand-outs can be downloaded free of charge from the internet. 606 $aErwachsenenbildung 606 $aStrategie 606 $aSeminar 606 $aLerngruppen 606 $aGruppenprozesse 606 $aTrainer 606 $aLernsituation 606 $aKonfliktsituation 606 $aKonflikt 606 $aSeminarleitung 615 4$aErwachsenenbildung 615 4$aStrategie 615 4$aSeminar 615 4$aLerngruppen 615 4$aGruppenprozesse 615 4$aTrainer 615 4$aLernsituation 615 4$aKonfliktsituation 615 4$aKonflikt 615 4$aSeminarleitung 676 $a374 700 $aSzepansky$b Wolf-Peter$4aut$01836157 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910149633003321 996 $aSouvera?n Seminare leiten$94413945 997 $aUNINA