LEADER 03543nam 2200817 450 001 9910780640503321 005 20230912160144.0 010 $a0-8020-4709-2 010 $a1-282-02883-9 010 $a9786612028830 010 $a1-4426-7935-2 024 7 $a10.3138/9781442679351 035 $a(CKB)2430000000011204 035 $a(EBL)4671910 035 $a(SSID)ssj0000308454 035 $a(PQKBManifestationID)11925121 035 $a(PQKBTitleCode)TC0000308454 035 $a(PQKBWorkID)10258262 035 $a(PQKB)10330205 035 $a(CaBNvSL)thg00600577 035 $a(DE-B1597)464827 035 $a(OCoLC)1013937431 035 $a(OCoLC)944177617 035 $a(DE-B1597)9781442679351 035 $a(Au-PeEL)EBL4671910 035 $a(CaPaEBR)ebr11257599 035 $a(OCoLC)244768766 035 $a(VaAlCD)20.500.12592/1w5c3c 035 $a(schport)gibson_crkn/2009-12-01/6/418140 035 $a(MiAaPQ)EBC4671910 035 $a(MdBmJHUP)musev2_105174 035 $a(MiAaPQ)EBC3255339 035 $a(EXLCZ)992430000000011204 100 $a20160922h20012001 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe ride to modernity $ethe bicycle in Canada, 1869-1900 /$fGlen Norcliffe 210 1$aToronto, [Ontario] ;$aBuffalo, [New York] ;$aLondon, [England] :$cUniversity of Toronto Press,$d2001. 210 4$dİ2001 215 $a1 online resource (305 p.) 300 $aDescription based upon print version of record. 311 $a0-8020-4398-4 311 $a0-8020-8205-X 320 $aIncludes bibliographical references and index. 327 $aModernity and the bicycle -- The bicycle carrier wave -- Modern manufacturing: from artisanal production to mass production -- Bells and whistles: the bicycle accessory industry -- Bad roads, Good Roads -- The cycling crowd: modern life on wheels -- Larger spaces and visible places -- Pedaller's progress: the bicycle and modernity. 330 1 $a"This is the story of Canada's encounter with the bicycle in the late nineteenth century, set in the context of the cultural movement known as 'modernity.' Glen Norcliffe covers the bicycle's history from about 1869, when the first bicycle appeared in Canada, until about 1900, a date that marks the end of the era when bicycles were a recognized symbol of modernity and social status. Cycling continued into the Edwardian period and beyond, of course, especially in Europe, but by then it had lost its symbolic status and social cachet in Canada." "Norcliffe's aim is to examine how the bicycle fits into the larger picture of change and progress in a period of dramatic economic, social, and technological flux"--Page 4 of cover. 606 $aBicycles$zCanada$xHistory$y19th century 606 $aCycling$zCanada$xHistory$y19th century 606 $aCycling$xSocial aspects$zCanada 606 $aBicycle industry$zCanada$xHistory$y19th century 607 $aCanada$2fast 608 $aLivres numeriques. 608 $aHistory. 608 $ae-books. 608 $aElectronic books. 615 0$aBicycles$xHistory 615 0$aCycling$xHistory 615 0$aCycling$xSocial aspects 615 0$aBicycle industry$xHistory 676 $a796.6/0971 700 $aNorcliffe$b G. B.$0129874 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910780640503321 996 $aThe ride to modernity$93733271 997 $aUNINA LEADER 03365nam 22005895 450 001 9910149489103321 005 20200705051715.0 024 7 $a10.1007/978-3-319-43589-3 035 $a(CKB)3710000000928157 035 $a(DE-He213)978-3-319-43589-3 035 $a(MiAaPQ)EBC4732592 035 $a(PPN)197138047 035 $a(EXLCZ)993710000000928157 100 $a20161103d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAMP-activated Protein Kinase /$fedited by Mario D. Cordero, Benoit Viollet 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (X, 523 p. 55 illus., 42 illus. in color.) 225 1 $aExperientia Supplementum,$x1664-431X ;$v107 311 $a3-319-43587-6 311 $a3-319-43589-2 320 $aIncludes bibliographical references at the end of each chapters. 327 $aPart I: AMPK in health -- Structure and Regulation of AMPK -- AMPK Regulation of Carbohydrate Metabolism -- AMPK Regulation of Lipid Metabolism -- AMPK Regulation of Protein Metabolism -- AMPK Regulation of cell growth, apoptosis, autophagy and bioenergetics -- AMPK Regulation of immunology -- AMPK and Stem Cells -- Part II: AMPK in the diseases -- AMPK in metabolic diseases -- AMPK in neurodegenerative diseases -- AMPK in cardiovascular diseases -- AMPK in cancer -- AMPK in aging -- AMPK in musculoskeletal diseases and pain -- AMPK in pathogens -- Part III: Pharmacology of AMPK -- Metformin, new drugs and AMPK -- Small molecules and AMPK -- Nutraceutical compounds and AMPK -- Part IV: Methods of study in AMPK -- Animal models -- In vitro study methods. 330 $aAMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes. This book focuses on the implications of AMPK as a master metabolic regulator in diseases, including new methods and animal models. 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