LEADER 03357nam 22005895 450 001 9910149489103321 005 20200705051715.0 024 7 $a10.1007/978-3-319-43589-3 035 $a(CKB)3710000000928157 035 $a(DE-He213)978-3-319-43589-3 035 $a(MiAaPQ)EBC4732592 035 $a(PPN)197138047 035 $a(EXLCZ)993710000000928157 100 $a20161103d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAMP-activated Protein Kinase /$fedited by Mario D. Cordero, Benoit Viollet 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (X, 523 p. 55 illus., 42 illus. in color.) 225 1 $aExperientia Supplementum,$x1664-431X ;$v107 311 $a3-319-43587-6 311 $a3-319-43589-2 320 $aIncludes bibliographical references at the end of each chapters. 327 $aPart I: AMPK in health -- Structure and Regulation of AMPK -- AMPK Regulation of Carbohydrate Metabolism -- AMPK Regulation of Lipid Metabolism -- AMPK Regulation of Protein Metabolism -- AMPK Regulation of cell growth, apoptosis, autophagy and bioenergetics -- AMPK Regulation of immunology -- AMPK and Stem Cells -- Part II: AMPK in the diseases -- AMPK in metabolic diseases -- AMPK in neurodegenerative diseases -- AMPK in cardiovascular diseases -- AMPK in cancer -- AMPK in aging -- AMPK in musculoskeletal diseases and pain -- AMPK in pathogens -- Part III: Pharmacology of AMPK -- Metformin, new drugs and AMPK -- Small molecules and AMPK -- Nutraceutical compounds and AMPK -- Part IV: Methods of study in AMPK -- Animal models -- In vitro study methods. 330 $aAMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes. This book focuses on the implications of AMPK as a master metabolic regulator in diseases, including new methods and animal models. The contributions are written by leading experts in the field and give an extensive overview of the current knowledge of AMPK biology and the role of AMPK in health and disease. . 410 0$aExperientia Supplementum,$x1664-431X ;$v107 606 $aHuman physiology 606 $aMedical biochemistry 606 $aMetabolic diseases 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aMedical Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/H35005 606 $aMetabolic Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33118 615 0$aHuman physiology. 615 0$aMedical biochemistry. 615 0$aMetabolic diseases. 615 14$aHuman Physiology. 615 24$aMedical Biochemistry. 615 24$aMetabolic Diseases. 676 $a572.792 702 $aCordero$b Mario D$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aViollet$b Benoit$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910149489103321 996 $aAMP-activated Protein Kinase$92529009 997 $aUNINA