LEADER 03490nam 22005415 450 001 9910149465303321 005 20200703073202.0 010 $a3-319-46527-9 024 7 $a10.1007/978-3-319-46527-2 035 $a(CKB)3710000000934440 035 $a(DE-He213)978-3-319-46527-2 035 $a(MiAaPQ)EBC4734214 035 $a(PPN)197138411 035 $a(EXLCZ)993710000000934440 100 $a20161107d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAcute Lung Injury and Repair $eScientific Fundamentals and Methods /$fedited by Lynn M. Schnapp, Carol Feghali-Bostwick 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Humana,$d2017. 215 $a1 online resource (VIII, 185 p. 23 illus., 20 illus. in color.) 225 1 $aRespiratory Medicine,$x2197-7372 311 $a3-319-46525-2 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aMethods to Study Lung Injury and Repair -- Mouse Models of Acute Lung Injury -- Transgenic Animal Models in Lung Research -- Fundamental Methods for Analysis of Acute Lung Injury in Mice -- Invasive Measurement of Pulmonary Function in Mice -- Analysis of Epithelial Injury and Repair -- Flow Cytometric Evaluation of Acute Lung Injury and Repair -- Lung Imaging in Animal Models -- Genetic and Genomic Approaches to Acute Lung Injury -- MicroRNA Analysis in Acute Lung Injury. 330 $aAcute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population Several clinical disorders can initiate ARDS, including pneumonia, sepsis, gastric aspiration and trauma but despite intense research over the past 40 years, we still have an incomplete understanding of the pathophysiology of the disease and treatment remains largely supportive. This book provides an overview of acute lung injury and repair, describes current animal models to study lung injury and reviews current methodologies to study and measure lung injury and repair. Special emphasis is given to state of the art techniques and methods and relevance to human disease. 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