LEADER 02823oam 2200493I 450 001 9910149366303321 005 20240501153337.0 010 $a1-315-36731-9 010 $a1-315-35020-3 010 $a1-4987-6800-8 024 7 $a10.1201/9781315367316 035 $a(CKB)3710000000933759 035 $a(MiAaPQ)EBC4732218 035 $a(OCoLC)962305641 035 $a(EXLCZ)993710000000933759 100 $a20180331h20172017 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aHandbook for chemical process research and development /$fWenyi Zhao 205 $a1st ed. 210 1$aBoca Raton :$cCRC Press,$d[2017] 210 4$dİ2017 215 $a1 online resource (859 pages) $cillustrations 300 $aIncludes index. 311 08$a1-4987-6799-0 327 $aChapter 1. Modes of reagent addition : control of impurity formation -- Chapter 2. Process optimization -- Chapter 3. Hazardous reactions -- Chapter 4. Catalytic reactions -- Chapter 5. Grignard reagent and related reactions -- Chapter 6. Challenging reaction intermediates -- Chapter 7. Protecting groups -- Chapter 8. Reaction solvents -- Chapter 9. Base reagent selection -- Chapter 10. Reagents for amide formation -- Chapter 11. Various reagent surrogates -- Chapter 12. Telescope approach -- Chapter 13. Stereochemistry -- Chapter 14. Design of new synthetic route -- Chapter 15. Reaction workup -- Chapter 16. Pharmaceutical salts -- Chapter 17. Solid form. 330 $aThe Handbook for Chemical Process Research and Development focuses on developing processes for chemical and pharmaceutical industries. Forty years ago there were few process research and development activities in the pharmaceutical industry, partially due to the simplicity of the drug molecules. However, with the increasing structural complexity, especially the introduction of chiral centers into the drug molecules and strict regulations set by the EMA and FDA, process R&D has become one of the critical departments for pharmaceutical companies. This book assists with the key responsibility of process chemists to develop chemical processes for manufacturing pharmaceutical intermediates and final drug substances for clinical studies and commercial production. 606 $aDrugs$xResearch 606 $aDrugs$xResearch$xMethodology 606 $aPharmaceutical industry 615 0$aDrugs$xResearch. 615 0$aDrugs$xResearch$xMethodology. 615 0$aPharmaceutical industry. 676 $a615.1/9 700 $aZhao$b Wenyi$c(Chemist),$0918067 801 0$bFlBoTFG 801 1$bFlBoTFG 906 $aBOOK 912 $a9910149366303321 996 $aHandbook for chemical process research and development$92058500 997 $aUNINA