LEADER 05445nam 2200985Ia 450 001 9910146416703321 005 20251117053027.0 010 $a9786611937799 010 $a9781281937797 010 $a1281937797 010 $a9789240683440 010 $a9240683445 035 $a(CKB)1000000000746694 035 $a(EBL)380895 035 $a(OCoLC)476210675 035 $a(SSID)ssj0000309606 035 $a(PQKBManifestationID)11257932 035 $a(PQKBTitleCode)TC0000309606 035 $a(PQKBWorkID)10283705 035 $a(PQKB)10415090 035 $a(MiAaPQ)EBC380895 035 $a(Au-PeEL)EBL380895 035 $a(CaPaEBR)ebr10266344 035 $a(CaONFJC)MIL193779 035 $a(EXLCZ)991000000000746694 100 $a20081027d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSkin sensitization in chemical risk assessment 205 $a1st ed. 210 $aGeneva, Switzerland $cWorld Health Organization$dc2008 215 $a1 online resource (90 p.) 225 1 $aHarmonization Project document ;$vno. 5 300 $a"IPCS International Programme on Chemical Safety". 311 1 $a9789241563604 311 1 $a9241563605 320 $aIncludes bibliographical references. 327 $aSkin Sensitization in Chemical Risk Assessment: Report of a WHO/IPCS International Workshop Focusing on Dose-Response Assessment / H. Van Loveren, A. Cockshott, T. Gebel, U. Gundert-Remy, W.H. De Jong, J. Matheson, H. McGarry, L. Musset, M.K. Selgrade and C. Vickers -- Appendix A. Abstracts -- The use of human data when conducting dermal sensitization quantitative risk assessments for fragrance ingredients / A.M. Api -- Application of the local lymph node assay (LLNA) for respiratory sensitizers / J.H.E. Arts, W.H. De Jong, H. Van Loveren and C.F. Kuper -- Information derived from sensitization test methods: test sensitivity, false positives, and false negatives / D. Basketter -- Skin sensitization -- a regulatory overview / A. Cockshott -- Quantification, potency, and risk assessment: induction versus elicitation / G.P. Gerberick -- Uncertainty factors and risk assessment for skin sensitizers / P. Griem -- Hazard identification (human data) / J.D. Johansen -- Clinical experience informing risk assessment / C. Liden -- Perspective of the United States Environmental Protection Agency's Office of Pesticide Programs on assessment of dermal sensitization risk using hexavalent chromium as a case-study / T.F. McMahon and J. Chen -- New approaches for skin sensitization hazard identification: (Q)SARs/expert systems / G. Patlewicz -- New approaches for hazard identification: the development of in vitro methods for predicting contact sensitization potential / C.A. Ryan -- Sensitization potency of chemicals / M. Takeyoshi -- New approaches to hazard identification: non-radioactive alternatives / H.-W. Vohr. 330 $aThis Harmonization Project Document presents the conclusions of an IPCS Workshop on Skin Sensitization in Chemical Risk Assessment. The workshop focused on the question of methods for dose-response assessment, to evaluate the relative ability of a chemical to induce sensitization in the skin, and hence inform risk assessment for humans. In addition this publication includes a series of short articles on this topic by leading experts in the field. The conclusions of the workshop cover such aspects as the nature and utility for risk assessment of the data produced by non-animal test methods (suc 410 0$aHarmonization Project document ;$vno. 5. 606 $aChemicals$xPhysiological effect 606 $aChemicals$xRisk assessment 606 $aSkin tests 606 $aToxicology 606 $aHealth risk assessment 606 $aHazardous susbtances$xRisk assessment 606 $aHealth status indicators 606 $aDermatitis, Contact$xphysiopathology$3(DNLM)D003877Q000503 606 $aHazardous Substances$xtoxicity$3(DNLM)D015386Q000633 606 $aSkin Tests$xmethods$3(DNLM)D012882Q000379 606 $aRisk Assessment$xmethods$3(DNLM)D018570Q000379 606 $aSkin Tests$3(DNLM)D012882 606 $aToxicology$3(DNLM)D014116 606 $aHealth Status Indicators$3(DNLM)D006305 615 0$aChemicals$xPhysiological effect. 615 0$aChemicals$xRisk assessment. 615 0$aSkin tests. 615 0$aToxicology. 615 0$aHealth risk assessment. 615 0$aHazardous susbtances$xRisk assessment. 615 0$aHealth status indicators. 615 12$aDermatitis, Contact$xphysiopathology. 615 22$aHazardous Substances$xtoxicity. 615 22$aSkin Tests$xmethods. 615 22$aRisk Assessment$xmethods. 615 2$aSkin Tests. 615 2$aToxicology. 615 2$aHealth Status Indicators. 676 $a616.994071 701 $aLoveren$b Hendrik van$f1951-$0845390 712 02$aWorld Health Organization. 712 02$aInternational Program on Chemical Safety. 712 02$aInternational Labour Organisation. 712 02$aUnited Nations Environment Programme. 712 02$aInter-Organization Programme for the Sound Management of Chemicals. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910146416703321 996 $aSkin sensitization in chemical risk assessment$91886719 997 $aUNINA