LEADER 05142nam 2200649Ia 450 001 9910146245703321 005 20220120152114.0 010 $a1-280-56086-X 010 $a9786610560868 010 $a3-527-60605-X 010 $a3-527-60236-4 035 $a(CKB)1000000000019292 035 $a(EBL)481763 035 $a(OCoLC)123896248 035 $a(SSID)ssj0000111593 035 $a(PQKBManifestationID)11137789 035 $a(PQKBTitleCode)TC0000111593 035 $a(PQKBWorkID)10080398 035 $a(PQKB)10442447 035 $a(MiAaPQ)EBC481763 035 $a(EXLCZ)991000000000019292 100 $a20040412d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBiocatalysis$b[electronic resource] /$fA. S. Bommarius, B. R. Riebel 210 $aWeinheim ;$aCambridge $cWiley-VCH$dc2004 215 $a1 online resource (637 p.) 300 $aDescription based upon print version of record. 311 $a3-527-30344-8 320 $aIncludes bibliographical references (p.591-592) and index. 327 $aBiocatalysis; Preface; Acknowledgments; Contents; 1 Introduction to Biocatalysis; 1.1 Overview: The Status of Biocatalysis at the Turn of the 21st Century; 1.1.1 State of Acceptance of Biocatalysis; 1.1.2 Current Advantages and Drawbacks of Biocatalysis; 1.1.2.1 Advantages of Biocatalysts; 1.1.2.2 Drawbacks of Current Biocatalysts; 1.2 Characteristics of Biocatalysis as a Technology; 1.2.1 Contributing Disciplines and Areas of Application; 1.2.2 Characteristics of Biocatalytic Transformations; 1.2.2.1 Comparison of Biocatalysis with other Kinds of Catalysis 327 $a1.2.3 Applications of Biocatalysis in Industry1.2.3.1 Chemical Industry of the Future: Environmentally Benign Manufacturing, Green Chemistry, Sustainable Development in the Future; 1.2.3.2 Enantiomerically Pure Drugs or Advanced Pharmaceutical Intermediates (APIs); 1.3 Current Penetration of Biocatalysis; 1.3.1 The Past: Historical Digest of Enzyme Catalysis; 1.3.2 The Present: Status of Biocatalytic Processes; 1.4 The Breadth of Biocatalysis; 1.4.1 Nomenclature of Enzymes; 1.4.2 Biocatalysis and Organic Chemistry, or "Do we Need to Forget our Organic Chemistry?" 327 $a2 Characterization of a (Bio-)catalyst2.1 Characterization of Enzyme Catalysis; 2.1.1 Basis of the Activity of Enzymes: What is Enzyme Catalysis?; 2.1.1.1 Enzyme Reaction in a Reaction Coordinate Diagram; 2.1.2 Development of Enzyme Kinetics from Binding and Catalysis; 2.2 Sources and Reasons for the Activity of Enzymes as Catalysts; 2.2.1 Chronology of the Most Important Theories of Enzyme Activity; 2.2.2 Origin of Enzymatic Activity: Derivation of the Kurz Equation; 2.2.3 Consequences of the Kurz Equation; 2.2.4 Efficiency of Enzyme Catalysis: Beyond Pauling's Postulate 327 $a2.3 Performance Criteria for Catalysts, Processes, and Process Routes2.3.1 Basic Performance Criteria for a Catalyst: Activity, Selectivity and Stability of Enzymes; 2.3.1.1 Activity; 2.3.1.2 Selectivity; 2.3.1.3 Stability; 2.3.2 Performance Criteria for the Process; 2.3.2.1 Product Yield; 2.3.2.2 (Bio)catalyst Productivity; 2.3.2.3 (Bio)catalyst Stability; 2.3.2.4 Reactor Productivity; 2.3.3 Links between Enzyme Reaction Performance Parameters; 2.3.3.1 Rate Acceleration; 2.3.3.2 Ratio between Catalytic Constant k(cat) and Deactivation Rate Constant k(d) 327 $a2.3.3.3 Relationship between Deactivation Rate Constant k(d) and Total Turnover Number TTN2.3.4 Performance Criteria for Process Schemes, Atom Economy, and Environmental Quotient; 3 Isolation and Preparation of Microorganisms; 3.1 Introduction; 3.2 Screening of New Enzyme Activities; 3.2.1 Growth Rates in Nature; 3.2.2 Methods in Microbial Ecology; 3.3 Strain Development; 3.3.1 Range of Industrial Products from Microorganisms; 3.3.2 Strain Improvement; 3.4 Extremophiles; 3.4.1 Extremophiles in Industry; 3.5 Rapid Screening of Biocatalysts; 4 Molecular Biology Tools for Biocatalysis 327 $a4.1 Molecular Biology Basics: DNA versus Protein Level 330 $aThe whole range of biocatalysis, from a firm grounding in theoretical concepts to in-depth coverage of practical applications and future perspectives. The book not only covers reactions, products and processes with and from biological catalysts, but also the process of designing and improving such biocatalysts.One unique feature is that the fields of chemistry, biology and bioengineering receive equal attention, thus addressing practitioners and students from all three areas. 606 $aEnzymes$xBiotechnology 606 $aBiosynthesis 606 $aCatalysis 608 $aElectronic books. 615 0$aEnzymes$xBiotechnology. 615 0$aBiosynthesis. 615 0$aCatalysis. 676 $a660.634 700 $aBommarius$b A. S$g(Andreas Sebastian)$0442347 701 $aRiebel$b B. R$g(Bettina R.)$0442348 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910146245703321 996 $aBiocatalysis$985079 997 $aUNINA LEADER 05404nam 2200697 a 450 001 9911019365203321 005 20251116151932.0 010 $a9786610519798 010 $a9781280519796 010 $a1280519797 010 $a9783527603909 010 $a3527603905 010 $a9783527604494 010 $a3527604499 035 $a(CKB)1000000000376382 035 $a(EBL)481350 035 $a(OCoLC)68570700 035 $a(SSID)ssj0000167566 035 $a(PQKBManifestationID)11924596 035 $a(PQKBTitleCode)TC0000167566 035 $a(PQKBWorkID)10177673 035 $a(PQKB)11394222 035 $a(MiAaPQ)EBC481350 035 $a(PPN)155908480 035 $a(Perlego)2761303 035 $a(EXLCZ)991000000000376382 100 $a20041019d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHandbook of fluorous chemistry /$fJohn A. Gladysz, Dennis P. Curran, Istvan T. Horvath (Eds.) 210 $aWeinheim $cWiley-VCH$dc2004 215 $a1 online resource (627 p.) 300 $aDescription based upon print version of record. 311 08$a9783527306176 311 08$a352730617X 320 $aIncludes bibliographical references and index. 327 $aHandbook of Fluorous Chemistry; Contents; Preface; Contributors; 1 Fluorous Chemistry: Scope and Definition; 1.1 The Birth of a Term; 1.2 The Definition of Fluorous Today; 1.3 Other Definitions within the Fluorous Repertoire; 1.4 Present Scope of Fluorous Chemistry; References; 2 A Personal View of the History of Fluorous Chemistry; References; 3 Fluorous Solvents and Related Media; 3.1 Introductory Remarks; 3.2 Commercial Fluorous Solvents; 3.3 Related Solvents and Media; 3.3.1 Amphiphilic or Hybrid Solvents; 3.3.2 Fluorous Ionic Liquids; 3.3.3 ""Faux Fluorous"" Solvents 327 $a3.3.4 Fluorous Greases3.3.5 Bonded Fluorous Phases; 3.4 Polarities of Fluorous Solvents; 3.5 Solubilities of Solutes in Fluorous Solvents; 3.5.1 General Aspects; 3.5.2 Gas Solubilities; 3.6 Fluorous/Non-fluorous Solvent Miscibilities; 3.7 Special Reactivity Phenomena in Fluorous Solvents; References; 4 Strategies for the Recovery of Fluorous Catalysts and Reagents: Design and Evaluation; 4.1 Introduction; Basic Recycling Concepts; 4.2 Fluorous/Non-Fluorous Liquid/Liquid Biphase Catalysis; 4.3 Fluorous Catalysis in Amphiphilic or Hybrid Solvents 327 $a4.4 Fluorous Catalysis Without Non-Fluorous Solvents4.5 Fluorous Catalysis Without Fluorous Solvents; 4.5.1 Thermomorphic Catalysts; 4.5.2 Other Approaches; 4.6 Fluorous Catalysis Without Solvents; 4.7 Recovery of Fluorous Catalysts using Supports; 4.8 Criteria for Recoverability; 4.8.1 Yield as a Function of Cycle; 4.8.2 TOF as a Function of Cycle; 4.8.3 Catalyst Inventory; 4.9 Slanting Data: How to Make a Non-recoverable Catalyst Appear Recoverable; 4.10 Prospects; References; 5 Ponytails: Structural and Electronic Considerations; 5.1 Introduction; 5.2 Structural Aspects of Ponytails 327 $a5.3 NMR Characterization of Ponytails5.4 Electronic Effects: Introduction; 5.5 Electronic Effects: IR Data; 5.6 Electronic Effects: Gas Phase Ionization Data; 5.7 Electronic Effects: Calorimetry; 5.8 Electronic Effects: Solution Equilibria; 5.9 Electronic Effects: Computational Data; 5.10 Electronic Effects: Reactivity; 5.11 Electronic Effects: Additional Probes; 5.12 Electronic Effects: Conclusions; References; 6 Partition Coefficients Involving Fluorous Solvents; 6.1 Introduction; 6.2 Literature Data; 6.3 Trends with Respect to Functional Groups; 6.3.1 Non-Aromatic Hydrocarbons 327 $a6.3.2 Non-Aromatic Monofunctional Compounds6.3.3 Simple Monoarenes; 6.3.4 Triarylphosphines; 6.3.5 Pyridines; 6.3.6 Metal Complexes; 6.4 General Trends and Special Situations; 6.5 Quantitative Analysis and Prediction of Partition Coefficients; 6.6 Future Directions; 6.7 Sample Experimental Determinations; References; 7 Separations with Fluorous Silica Gel and Related Materials; 7.1 Introduction; 7.1.1 Fluorous Silica Gel; 7.1.2 Types and Sources of Fluorous Silica Gel Materials and Products; 7.2 Fluorous Solid Phase Extraction (FSPE) 327 $a7.2.1 Fluorous Solid Phase Extraction and its Relationship to Chromatography and Liquid/Liquid Extraction 330 $aEdited by the leading experts John Gladysz, Dennis Curran, and Istv?n Horv?th, this handbook is the first to summarize all the essential aspects of this emerging field of chemistry. Whether the reader is seeking an introduction to the concept of fluorous biphase catalysis, summaries of partition coefficients involving fluorous and organic solvents, or information on the latest fluorous mixture separation techniques, this authoritative compilation of contributions, written by the world's top authors, provides key information needed for successfully working with the diverse and fascinating famil 606 $aFluorine compounds 606 $aFluorine 615 0$aFluorine compounds. 615 0$aFluorine. 676 $a546/.731 701 $aGladysz$b John A$01839437 701 $aCurran$b Dennis P$092868 701 $aHorva?th$b Istva?n T$01839438 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019365203321 996 $aHandbook of fluorous chemistry$94418659 997 $aUNINA