LEADER 05348nam 22006734a 450 001 9910146242903321 005 20170809173110.0 010 $a1-280-52038-8 010 $a9786610520381 010 $a3-527-60529-0 010 $a3-527-60145-7 035 $a(CKB)1000000000019317 035 $a(EBL)481642 035 $a(OCoLC)174056223 035 $a(SSID)ssj0000104500 035 $a(PQKBManifestationID)11138246 035 $a(PQKBTitleCode)TC0000104500 035 $a(PQKBWorkID)10079755 035 $a(PQKB)11381024 035 $a(MiAaPQ)EBC481642 035 $a(EXLCZ)991000000000019317 100 $a20030331d2003 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aApoptosis and autoimmunity$b[electronic resource] /$fedited by M. Hermann and J.R. Kalden 210 $aWeinheim $cWiley-VCH$dc2003 215 $a1 online resource (405 p.) 300 $a"From mechanism to treatments"--Cover. 311 $a3-527-30442-8 320 $aIncludes bibliographical references and index. 327 $aApoptosis and Autoimmunity; Preface; Contents; List of Contributors; Part 1 General Features of Apoptosis; 1 Apoptosis and Autoimmunity; 1.1 Introduction; 1.2 Autoimmune Diseases Associated with Targeted Cell Destruction; 1.2.1 What is the Mode of Cell Death?; 1.2.2 What Cells and What Effector Pathways are Responsible for Cell Death?; 1.3 Autoimmune Diseases Associated with Enhanced Cell Growth and Survival; 1.4 Autoimmune Diseases Associated with Abnormal Processing of Dying Cells; 1.5 Conclusions; 1.6 References; 2 Caspase Knockouts: Matters of Life and Death 327 $a2.1 Death, Development and Immune Function2.2 Apoptotic Pathways: from Nematode to Mammals; 2.3 Triggering a Killer: General Aspects of Caspase Activation; 2.4 Caspase-1 and -11: More than Mediators of Inflammatory Cytokines?; 2.5 Caspase-8 and the FAS Signaling Pathway; 2.6 Caspase-3: The Chief Executioner?; 2.7 Caspase-9: Mitochondrial Activation and the Apoptosome; 2.8 Caspase-2: A Duality of Function; 2.9 Caspase-12: Responding to Stress; 2.10 Compensatory Caspase Activation: A Caveat to Knockout Analysis; 2.11 Caspases: More than Simple Killers; 2.12 Concluding Remarks; 2.13 References 327 $aPart 2 Clearance of Apoptotic Cells3 Anti-inflammatory and Immunoregulatory Effects of Apoptotic Cells; 3.1 Introduction; 3.2 Anti-inflammatory Effects of Apoptotic Cells on Monocytes/Macrophages; 3.3 The Role of Anti-inflammatory Cytokines for the Inhibition of Pro-inflammatory Cytokine Production; 3.4 Monocyte/Macrophage Receptors receiving the Anti-inflammatory Signal from Apoptotic Cells; 3.5 Intracellular Signaling Events Causing the Anti-inflammatory State in Macrophages; 3.6 Apoptotic Cells Impair MHC Class II Surface Expression on Monocytes 327 $a3.7 Influence of Apoptotic Cells on DC Function in Allogeneic MLR3.8 The Presence of Apoptotic Cells can Shift the T(h) Cell Response towards T(h)2; 3.9 Apoptotic Cells Suppress Delayed-type Hypersensitivity (DTH) In Vivo; 3.10 Necrosis and Inflammation; 3.11 Implications of the Anti-inflammatory and Immunodulatory Effects of Apoptotic Cells for Health and Disease; 3.11.1 Apoptosis and Pregnancy; 3.11.2 Apoptosis and Irradiation; 3.11.3 Apoptosis and Cancer; 3.11.4 Apoptosis and Infections; 3.11.5 Apoptosis and Blood Transfusions; 3.12 References; 4 Complement and Apoptosis; 4.1 Introduction 327 $a4.2 Programmed Cell Death (PCD)4.3 Complement; 4.4 Complement and Apoptosis; 4.4.1 Role of Complement in the Execution Phase; 4.4.2 Complement Activation by Apoptotic Cells; 4.5 Apoptosis, Complement and Autoimmunity; 4.6 References; 5 Soluble Factors that Bind to Dying Cells Control the Outcome of Corpse Disposal: The Role of Pentraxins, Collectins and Autoantibodies; 5.1 Introduction; 5.2 Soluble Factors Involved in Apoptotic Cell Recognition and Internalization; 5.2.1 Corpse Clearance at Rest: Collectins; 5.2.2 Corpse Clearance at Rest: Cationic Factors and Other PS-binding Moieties 327 $a5.2.3 Corpse Clearance during Acute Inflammation: Pentraxins 330 $aThis is the first comprehensive book about the relationship between apoptosis and autoimmune diseases. It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies. 606 $aApoptosis 606 $aAutoimmunity 606 $aAutoimmune diseases 608 $aElectronic books. 615 0$aApoptosis. 615 0$aAutoimmunity. 615 0$aAutoimmune diseases. 676 $a571.9/73 676 $a616.97/8 676 $a616.978 701 $aHerrmann$b M$g(Martin),$cDr.$0958325 701 $aKalden$b J. R$g(Joachim Robert)$0958326 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910146242903321 996 $aApoptosis and autoimmunity$92171242 997 $aUNINA LEADER 04332oam 2200685I 450 001 9910786193503321 005 20230126210132.0 010 $a1-283-97281-6 010 $a0-203-06640-5 010 $a1-135-07461-5 024 7 $a10.4324/9780203066409 035 $a(CKB)2670000000325580 035 $a(EBL)1114674 035 $a(OCoLC)827208945 035 $a(SSID)ssj0000821809 035 $a(PQKBManifestationID)12332315 035 $a(PQKBTitleCode)TC0000821809 035 $a(PQKBWorkID)10881197 035 $a(PQKB)11049159 035 $a(OCoLC)826685133 035 $a(MiAaPQ)EBC1114674 035 $a(Au-PeEL)EBL1114674 035 $a(CaPaEBR)ebr10650294 035 $a(CaONFJC)MIL428531 035 $a(FINmELB)ELB132349 035 $a(EXLCZ)992670000000325580 100 $a20180706d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe digital evolution of an American identity /$f. Waite 210 1$aNew York :$cRoutledge,$d2013. 215 $a1 online resource (136 p.) 225 0 $aRoutledge studies in science, technology, and society ;$v20 300 $aDescription based upon print version of record. 311 $a1-138-91468-1 311 $a0-415-89761-0 320 $aIncludes bibliographical references and index. 327 $aFront Cover; The Digital Evolution of an American Identity; Copyright Page; Contents; Acknowledgments; Section One; 1. The American Dilemma; The Theme of Individual Rights; Caught at Cross Purposes with Confl icting Goods; Greater Awareness of One's Choices; Unique Capabilities and Consequences; A Precarious Balance; 2. The Promise and the Peril; Community and Connectivity; Individualistic and Collectivistic Responses; The Legacy of the European Enlightenment; A New Social Environment; 3. Challenges of a Digital Culture; From Church Bell to Cell; The Example of Print 327 $aMacro Comparison of Print and Digital ErasMicro Comparison of Print and Digital Eras; The Twenty-First Century Enlightenment; Section Two; 4. Self versus Society: Inherent Tensions; Affi liation and Privacy; Bias and Scale; Tocqueville's Critique; Bellah's Response; Putnam's Analysis; 5. The Evolution of the First Amendment; Attitudes Regarding Free Speech; Speech Rights versus Privacy Rights; Instantaneous Access and Unpredictable Consequences; Constraints of Differing Environments; Speech, Ownership, and Control; 6. Inner and Outer Experience; Reflection and Reinvention; Language as Games 327 $aOpposition to AutonomyCommunitarianism; Enduring Fault Lines; Section Three; 7. New Forms of Conversations and Communities; A Changing Landscape; Engagement versus Isolation; From Neighborhood to Network; Different Conversations; Past and Future Converge; 8. The Challenge of Interdependence; Collective Knowledge; Connections and Patterns; Challenges for Disaster Response; Education Reconfigured; Tracking Health Care; 9. Beyond the Dichotomy of Self and Society; The Key Question; The Contours of a New Paradigm; Beyond Individualism; Unexpected Repercussions; References; Index 330 $aThe Digital Evolution of an American Identity details how the concept of American individualism is challenged by the digital revolution. As digital media alter our print-dominant culture, assumptions regarding the relationship of the individual to the larger community become increasingly problematic. Current arguments regarding freedom of speech and confusion about what is meant by privacy illustrate the nature of the challenge. C. Waite defines individualism as the ways in which the American culture traditionally strives to balance the rights of the individual against the nee 410 0$aRoutledge Studies in Science, Technology and Society 606 $aTechnology$xSocial aspects 606 $aDigital media 606 $aTechnological innovations 615 0$aTechnology$xSocial aspects. 615 0$aDigital media. 615 0$aTechnological innovations. 676 $a303.48/330973 700 $aWaite$b C.$01498855 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910786193503321 996 $aThe digital evolution of an American identity$93724537 997 $aUNINA