LEADER 05465nam 22007214a 450 001 9910146126403321 005 20200520144314.0 010 $a1-118-68787-6 010 $a1-118-68786-8 010 $a1-282-11755-6 010 $a9786612117558 010 $a1-4443-1130-1 035 $a(CKB)1000000000719775 035 $a(EBL)428063 035 $a(OCoLC)476272244 035 $a(SSID)ssj0000357659 035 $a(PQKBManifestationID)11269185 035 $a(PQKBTitleCode)TC0000357659 035 $a(PQKBWorkID)10358975 035 $a(PQKB)10167655 035 $a(MiAaPQ)EBC428063 035 $a(Au-PeEL)EBL428063 035 $a(CaPaEBR)ebr10303743 035 $a(CaONFJC)MIL211755 035 $a(PPN)242453732 035 $a(EXLCZ)991000000000719775 100 $a20020311d2003 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCellular physiology of nerve and muscle /$fGary G. Matthews 205 $a4th ed. 210 $aOsney Mead, Oxford ;$aMalden, MA $cBlackwell Pub.$dc2003 215 $a1 online resource (250 p.) 300 $aDescription based upon print version of record. 311 $a1-4051-0330-2 320 $aIncludes bibliographical references (p. [225]-229) and index. 327 $aCellular Physiology of Nerve and Muscle; Contents; Preface to the Fourth Edition; Acknowledgments; Part II Origin of Electrical Membrane Potential; 1 Introduction to Electrical Signaling in the Nervous System; The Patellar Reflex as a Model for Neural Function; The Cellular Organization of Neurons; Electrical Signals in Neurons; Transmission between Neurons; 2 Composition of Intracellular and Extracellular Fluids; Intracellular and Extracellular Fluids; The Structure of the Plasma Membrane; Summary; 3 Maintenance of Cell Volume; Molarity, Molality, and Diffusion of Water 327 $aOsmotic Balance and Cell VolumeAnswers to the Problem of Osmotic Balance; Tonicity; Time-course of Volume Changes; Summary; 4 Membrane Potential: Ionic Equilibrium; Diffusion Potential; Equilibrium Potential; The Nernst Equation; The Principle of Electrical Neutrality; The Cell Membrane as an Electrical Capacitor; Incorporating Osmotic Balance; Donnan Equilibrium; A Model Cell that Looks Like a Real Animal Cell; The Sodium Pump; Summary; 5 Membrane Potential: Ionic Steady State; Equilibrium Potentials for Sodium, Potassium, and Chloride; Ion Channels in the Plasma Membrane 327 $aMembrane Potential and Ionic PermeabilityThe Goldman Equation; Ionic Steady State; The Chloride Pump; Electrical Current and the Movement of Ions Across Membranes; Factors Affecting Ion Current Across a Cell Membrane; Membrane Permeability vs. Membrane Conductance; Behavior of Single Ion Channels; Summary; Part II Cellular Physiology of Nerve Cells; 6 Generation of Nerve Action Potential; The Action Potential; Ionic Permeability and Membrane Potential; Measuring the Long-distance Signal in Neurons; Characteristics of the Action Potential; Initiation and Propagation of Action Potentials 327 $aChanges in Relative Sodium Permeability During an Action PotentialVoltage-dependent Sodium Channels of the Neuron Membrane; Repolarization; The Refractory Period; Propagation of an Action Potential Along a Nerve Fiber; Factors Affecting the Speed of Action Potential Propagation; Molecular Properties of the Voltage-sensitive Sodium Channel; Molecular Properties of Voltage-dependent Potassium Channels; Calcium-dependent Action Potentials; Summary; 7 The Action Potential: Voltage-clamp Experiments; The Voltage Clamp; Measuring Changes in Membrane Ionic Conductance Using the Voltage Clamp 327 $aThe Squid Giant AxonIonic Currents Across an Axon Membrane Under Voltage Clamp; The Gated Ion Channel Model; Membrane Potential and Peak Ionic Conductance; Kinetics of the Change in Ionic Conductance Following a Step Depolarization; Sodium Inactivation; The Temporal Behavior of Sodium and Potassium Conductance; Gating Currents; Summary; 8 Synaptic Transmission at the Neuromuscular Junction; Chemical and Electrical Synapses; The Neuromuscular Junction as a Model Chemical Synapse; Transmission at a Chemical Synapse; Presynaptic Action Potential and Acetylcholine Release 327 $aEffect of Acetylcholine on the Muscle Cell 330 $aCellular Physiology of Nerve and Muscle, Fourth Edition offers a state of the art introduction to the basic physical, electrical and chemical principles central to the function of nerve and muscle cells. The text begins with an overview of the origin of electrical membrane potential, then clearly illustrates the cellular physiology of nerve cells and muscle cells. Throughout, this new edition simplifies difficult concepts with accessible models and straightforward descriptions of experimental results.An all-new introduction to electrical signaling in the nervous system. 606 $aNeurons 606 $aMuscle cells 606 $aNerves$xCytology 606 $aMuscles$xCytology 615 0$aNeurons. 615 0$aMuscle cells. 615 0$aNerves$xCytology. 615 0$aMuscles$xCytology. 676 $a573.8/36 700 $aMatthews$b Gary G.$f1949-$0531312 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910146126403321 996 $aCellular physiology of nerve and muscle$91573224 997 $aUNINA