LEADER 05317nam 2200649Ia 450 001 9910146115403321 005 20230721021126.0 010 $a1-282-34583-4 010 $a9786612345838 010 $a0-470-01030-4 010 $a0-470-01029-0 035 $a(CKB)1000000000725390 035 $a(EBL)470499 035 $a(SSID)ssj0000300541 035 $a(PQKBManifestationID)11205949 035 $a(PQKBTitleCode)TC0000300541 035 $a(PQKBWorkID)10252683 035 $a(PQKB)11331415 035 $a(MiAaPQ)EBC470499 035 $a(OCoLC)352837118 035 $a(EXLCZ)991000000000725390 100 $a20080925d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aIron metabolism$b[electronic resource] $efrom molecular mechanisms to clinical consequences /$fRobert Crichton 205 $a3rd ed. 210 $aChichester, UK $cJohn Wiley & Sons$d2009 215 $a1 online resource (483 p.) 300 $aDescription based upon print version of record. 311 $a0-470-01028-2 320 $aIncludes bibliographical references and index. 327 $aIron Metabolism; Contents; Preface; 1. Solution Chemistry of Iron in Biological Media; 1.1 Aqueous Solution Chemistry of Iron; 1.1.1 Oxygen Free Radicals; 1.1.2 Iron Hydrolysis - a Ubiquitous Phenomenon; 1.1.3 Hydrolysis of Iron(III) in Acid Media - Formation of Polynuclear Species; 1.1.4 Ageing of Amorphous Ferrihydrite to more Crystalline Products; 1.2 Biomineralisation; 1.2.1 Magnetite Biomineralisation by Magnetotactic Bacteria; References; 2. The Importance of Iron for Biological Systems; 2.1 Introduction; 2.2 Physical Techniques for the Study of Iron in Biological Systems 327 $a2.3 Haemoproteins2.3.1 Oxygen Carriers; 2.3.2 Activators of Molecular Oxygen; 2.3.3 Electron Transport Proteins; 2.4 Iron-Sulfur Proteins; 2.5 Other Iron Containing Proteins; 2.5.1 Mononuclear Non-Haem Iron Enzymes; 2.5.2 Dinuclear Non-Haem Iron Enzymes; References; 3. Microbial Iron Transport and Metabolism; 3.1 Introduction; 3.2 Siderophores; 3.2.1 Iron Transport Across the Outer Membrane in Gram-Negative Bacteria; 3.2.2 Transport Across the Periplasm and Cytoplasmic Membrane; 3.2.3 Iron Release from Ferric Siderophores and Ferric Reduction; 3.2.4 Fe2+ Transport Systems in E. coli 327 $a3.2.5 Fe3+ Iron Acquisition by Pathogens3.3 Intracellular Iron Metabolism; 3.4 Control of Gene Expression by Iron; References; 4. Iron Uptake by Plants and Fungi; 4.1 Iron Acquisition by Plants; 4.1.1 Introduction; 4.1.2 Iron Acquisition by the Roots of Plants; 4.1.3 Long Distance Iron Transport; 4.1.4 Intracellular Iron Transport; 4.2 Iron Acquisition by Yeast; 4.2.1 Introduction - Pathways for Iron Uptake; 4.2.2 Cell Surface Reductases; 4.2.3 High Affinity Iron Transport System; 4.2.4 Low Affinity Ferrous Iron Transport; 4.2.5 Siderophore-Mediated Iron Uptake 327 $a4.2.6 Intracellular Iron Metabolism4.2.7 Iron Transport in Other Fungi; 4.2.8 Regulation of Iron Uptake/Homeostasis in Yeast; References; 5. Cellular Iron Uptake and Export in Mammals; 5.1 The Transferrins; 5.2 Structure of Transferrins; 5.3 Transferrin Iron Binding and Release; 5.4 Iron Uptake by Mammalian Cells - Uptake of Transferrin Bound Iron; 5.4.1 The Transferrin Receptor; 5.4.2 The Transferrin-to-Cell Cycle; 5.4.3 Transferrin Binding to its Receptor; 5.5 Cellular Iron Uptake and Export; 5.5.1 Red Blood Cell Precursors; 5.5.2 Tissue Macrophages; 5.5.3 Hepatocytes 327 $a5.6 Uptake of Iron from Other Sources than Transferrin5.7 Nontransferrin Bound Iron; 5.8 Ferritin Bound Iron; 5.9 Haptoglobin and Haemopexin as Iron Transporters; References; 6. Intracellular Iron Storage and Biomineralisation; 6.1 Intracellular Iron Storage; 6.1.1 Ferritin: Distribution and Primary Structure; 6.1.2 Three-Dimensional Structure; 6.1.3 The Mineral Core; 6.1.4 Iron Deposition in Ferritin; 6.1.5 Iron Mobilisation from Ferritin; 6.1.6 Haemosiderin; 6.2 Biomineralisation; References; 7. Intracellular Iron Metabolism and Cellular Iron Homeostasis; 7.1 Intracellular Iron Metabolism 327 $a7.1.1 The Labile Iron Pool 330 $aIron is of fundamental importance to the growth, development and well-being of almost all living organisms. Multiple biological systems have evolved for the uptake, utilisation, storage, and homeostasis of iron in microbes, plants and mammals. Both iron deficiency and iron overload are found extensively in humans; the intimate links between iron and oxidative stress are associated with a wide range of pathologies. Iron has a well established role in infections by a range of microorganisms and parasites. Other metals such as copper and zinc are also closely linked with iron metabolism. Iron ove 606 $aIron proteins 606 $aIron$xMetabolism$xDisorders 606 $aIron$xMetabolism 615 0$aIron proteins. 615 0$aIron$xMetabolism$xDisorders. 615 0$aIron$xMetabolism. 676 $a572.517 676 $a572/.5174 700 $aCrichton$b Robert R$0520760 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910146115403321 996 $aIron Metabolism$9834684 997 $aUNINA LEADER 07657oam 2200877 450 001 9910820440903321 005 20240129213206.0 010 $a1-63853-659-7 010 $a1-68420-096-2 024 7 $a10.1055/b-006-161172 035 $a(CKB)4100000010673771 035 $a(MiAaPQ)EBC6141308 035 $a10.1055-b-006-161172 035 $a(DE-2912)1586438476382 035 $a(MiAaPQ)EBC30682597 035 $a(Au-PeEL)EBL30682597 035 $a(EXLCZ)994100000010673771 100 $a20200619d2020 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBotulinum neurotoxin for head and neck disorders /$fAndrew Blitzer, Brian E. Benson, Diana N. Kirke, editors 205 $aSecond edition. 210 1$aNew York :$cThieme,$d[2020] 210 4$dİ2020 215 $a1 online resource (228 pages) $cillustrations 311 0 $a1-68420-095-4 320 $aIncludes bibliographical references and index. 327 $aPharmacology of Botulinum Neurotoxins / Muna I. Bitar, Nikita Kohli, Maya Samman, and Andrew Blitzer -- Botulinum Neurotoxin for Blepharospasm / Amit Patel, Andrew Blitzer, and Boris L. Bentsianov -- Botulinum Neurotoxin for Facial Dystonia / Scott M. Rickert, Amy P. Wu, and Andrew Blitzer Botulinum -- Neurotoxin for Meige Syndrome / Niv Mor and Andrew Blitzer -- Botulinum Neurotoxin for Oromandibular Dystonia / Daniel Novakovic and Ajay E. Chitkara -- Botulinum Neurotoxin for Spasmodic Dysphonia / Phillip C. Song, Lucian Sulica, and Andrew Blitzer -- Botulinum Neurotoxin for Cervical Dystonia / Tanya K. Meyer, Joel Guss, and Ronda E. Alexander -- Botulinum Neurotoxin for Hemifacial Spasm and Facial Synkinesis / Lesley French Childs, Daniel Novakovic, and Scott R. Gibbs -- Botulinum Neurotoxin for Hyperfunctional Facial Lines / Brian E. Benson, Diana N. Kirke, and Andrew Blitzer -- Botulinum Neurotoxin for Upper and Lower Esophageal Spasm / Nwanmegha Young and Brian E. Benson -- Botulinum Neurotoxin for Palatal Myoclonus / Ajay E. Chitkara, Catherine F. Sinclair, and Daniel Novakovic -- Botulinum Neurotoxin for Temporomandibular Disorders, Masseteric Hypertrophy, and Cosmetic Masseter Reduction / Michael Z. Lerner and Andrew Blitzer -- Botulinum Neurotoxin Therapy in the Laryngopharynx / Craig H. Zalvan, Phillip C. Song, Nwanmegha Young, and Andrew Blitzer -- Botulinum Neurotoxin for Migraine / Rachel Kaye, Jerome Schwartz, Brian E. Benson, and William J. Binder -- Botulinum Neurotoxin for Chronic Tension Headache / Nwanmegha Young and Brian E. Benson -- Botulinum Neurotoxin for Trigeminal Neuralgia / Elizabeth Guardiani, Andrew Blitzer, Lesley French Childs, and Ronda E. Alexander -- Botulinum Neurotoxin for Frey's Syndrome / Rachel Kaye, Andrew Blitzer, and Brian E. Benson -- Botulinum Neurotoxin for Facial Hyperhidrosis / Diana N. Kirke, Daniel Novakovic, and Andrew Blitzer -- Botulinum Neurotoxin for Sialorrhea / Brianna K. Crawley, Scott M. Rickert, Senja Tomovic, and Andrew Blitzer -- Botulinum Neurotoxin for Radiation-Induced Spasm and Pain / Diana N. Kirke, Brian E. Benson, and Tanya K. Meyer. 330 $a"Senior author Dr. Andrew Blitzer is an internationally renowned pioneer on the use of botulinum neurotoxin for functional disorders, with unparalleled expertise on this topic. Joined by co-editors Brian Benson and Diana Kirke, with multidisciplinary contributors, Botulinum Neurotoxin for Head and Neck Disorders Second Edition fills a gap in the medical literature. The unique textbook focuses on the use of botulinum neurotoxins for functional disorders of the head and neck, though with some aesthetic indications. The second edition reflects the latest advances and understanding of existing and emerging applications for botulinum neurotoxins, including new treatment paradigms, revised pharmacology, and an updated review of the literature in all chapters. Twenty superbly illustrated chapters cover the management of hyperfunctional, pain, and hypersecretory syndromes of the head and neck. Hyperfunctional motor disorders are discussed in chapters focused on blepharospasm, facial dystonia, Meige syndrome, oromandibular dystonia, spasmodic dysphonia (laryngeal dystonia), and cervical dystonia. Specific treatment approaches for pain are addressed in chapters on migraine and chronic daily tension headaches, temporomandibular disorders, and trigeminal neuralgia. 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