LEADER 05494nam 2200673Ia 450 001 9910146071703321 005 20170815112549.0 010 $a1-280-54216-0 010 $a9786610542161 010 $a0-471-68375-2 010 $a0-471-68377-9 035 $a(CKB)1000000000019149 035 $a(EBL)210535 035 $a(OCoLC)808029774 035 $a(SSID)ssj0000353899 035 $a(PQKBManifestationID)11264843 035 $a(PQKBTitleCode)TC0000353899 035 $a(PQKBWorkID)10305797 035 $a(PQKB)10170600 035 $a(MiAaPQ)EBC210535 035 $a(EXLCZ)991000000000019149 100 $a20041012d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBiomedical applications$b[electronic resource] /$fedited by Alaa S. Abd-El-Aziz ... [et al.] 210 $aHoboken, NJ $cWiley-Interscience$dc2004 215 $a1 online resource (234 p.) 225 1 $aMacromolecules containing metal and metal-like elements,$x1545-438X ;$vv. 3 300 $aDescription based upon print version of record. 311 $a0-471-66737-4 320 $aIncludes bibliographical references and index. 327 $aMacromolecules Containing Metal and Metal-Like Elements Volume 3; Contributors; Contents; Preface; Series Preface; 1. Organometallic Compounds in Biomedical Applications; I. Introduction; II. Case for Metal-Containing Bioactive Agents; A. Tin-Containing Biocidal Polymers; B. Ferrocene: A Therapeutic Role in Polymeric Systems?; C. Polymeric Moderation of OsO(4) Toxicity; III. Miscellaneous Polymers; A. Metal Chelation Polymers; B. Condensation Polymers; IV. Small-Molecule Analogs; V. Summary; VI. References; 2. Metal-Labeled DNA on Surfaces; I. Introduction; II. Ferrocene Nucleotides 327 $aIII. Ferrocene-DNA ConjugatesIV. Other Metal-DNA Conjugates; V. Metallated DNA; A. Cu-DNA; B. M-DNA; VI. Summary; VII. Acknowledgments; VIII. References; 3. Artificial DNA through Metal-Mediated Base Pairing: Structural Control and Discrete Metal Assembly; I. Introduction; II. Alternative Hydrogen-Bonding Schemes for DNA Base Pairing; III. Non-Hydrogen-Bonding Basepairs in DNA; IV. Metal-Mediated Base Pairing in DNA; A. Basic Concept; B. Artificial Nucleosides Designed for Metal-Mediated Base Pairs; C. Incorporation of a Metallo-Base Pair in DNA and Its Effect on Thermal Stability 327 $aD. Discrete Self-Assembled Metal Arrays in DNAV. Future Prospects for Artificial Metallo-DNA; VI. Summary; VII. References; 4. Organotin Macromolecules as Anticancer Drugs; I. General; II. Anticancer Activity of Small Organotin Compounds; III. Molecule-Level Studies on Monomeric Organotin Compounds; IV. Anticancer Activity of Organotin Polymers; V. Future Work; VI. References; 5. Organotin Oligomeric Drugs Containing the Antivirial Agent Acyclovir; I. Early History of Organotin Compounds; II. Mechanisms and Reactions; III. General Structures; IV. Acyclovir; V. Bioactivity of Related Compounds 327 $aVI. Experimental WorkVII. Results and Discussion; VIII. References; 6. Polymeric Ferrocene Conjugates as Antiproliferative Agents; I. Introduction; II. The Ferrocene-Ferricenium System in the Biological Environment; III. Polymer-Drug Conjugation as a Pharmaceutical Tool for Drug Delivery; IV. Polymer-Ferrocene Conjugates: Synthesis and Structure; A. The Carrier Component: Structural Considerations; B. Conjugates of Amide-Linked Ferrocene; C. Conjugates of Ester-Linked Ferrocene; V. Bioactivity Screening; VI. Summary and Conclusions; VII. Acknowledgments; VIII. References 327 $a7. Polymeric Platinum-Containing Drugs in the Treatment of CancerI. Introduction; II. Basic Mechanisms of Pt(II) Complex Formation; III. Nomenclature; IV. Currently Approved Platinum-Containing Compounds; V. Properties of Cisplatin; VI. Structure-Activity Relationships; VII. Polymer-Drug Conjugation Strategy and Possible Benefits; A. Polymers as Carriers; B. Polymers as Drugs; C. General; VIII. Mainchain-Incorporated cis-Diamine-Coordinated Platinum; A. Simple Amine Derivatives; B. Amino Acid Derivatives; C. Other Nitrogen-Platinum Products; D. Solution Stability; E. Thermal Stability 327 $aF. Antiviral Activity 330 $aMetal and metalloid-containing compounds exhibit a wide range of biological and biocidal activities, some of which have been employed in medicines and drugs. Polymers containing metal or metalloid functions become a natural extension of this effort; just as organic compound drugs have been chemically bound to polymers or physically imbibed into polymer matrices in order to provide a variety of useful advantages, the same opportunities exist for using metal and metalloid species. This volume will cover important biomedical applications of organometallic compounds, including metal-labeled DNA on 410 0$aMacromolecules containing metal and metal-like elements ;$vv. 3. 606 $aPolymers in medicine 606 $aMacromolecules 606 $aOrganometallic compounds 608 $aElectronic books. 615 0$aPolymers in medicine. 615 0$aMacromolecules. 615 0$aOrganometallic compounds. 676 $a547.7 676 $a610/.28 701 $aAbd-El-Aziz$b Alaa S$0869596 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910146071703321 996 $aBiomedical applications$91941556 997 $aUNINA