LEADER 04708oam 2201141zu 450 001 9910146065303321 005 20210721060448.0 010 $a1-280-55673-0 010 $a9786610556731 010 $a0-471-65615-1 010 $a0-471-65616-X 035 $a(CKB)1000000000019046 035 $a(SSID)ssj0000303502 035 $a(PQKBManifestationID)11212041 035 $a(PQKBTitleCode)TC0000303502 035 $a(PQKBWorkID)10275576 035 $a(PQKB)10119555 035 $a(MiAaPQ)EBC4957569 035 $a(Au-PeEL)EBL4957569 035 $a(CaONFJC)MIL55673 035 $a(OCoLC)1024283262 035 $a(EXLCZ)991000000000019046 100 $a20160829d2004 uy 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMolecular cancer therapeutics : strategies for drug discovery and development 210 31$a[Place of publication not identified]$cWiley Liss$d2004 215 $a1 online resource (362 pages) 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-471-43202-4 330 $aMolecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry issues, intellectual property concerns, and clinical development. This invaluable reference promotes understanding of steps involved in developing drug leads for industrial partnering and development. It provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell- and molecule-based drug screening strategies, as well as mouse models for cancer.; Coverage also includes how to refine drug leads for suitability in clinical testing, the special issues of clinical testing of molecular-targeted drugs, and intellectual property concerns. 606 $aCancer$xChemotherapy 606 $aCancer$xImmunotherapy 606 $aAntineoplastic agents$xDevelopment 606 $aPharmacogenetics 606 $aAntineoplastic Agents 606 $aDrug Delivery Systems 606 $aDrug Evaluation 606 $aNeoplasms 606 $aDrug Therapy 606 $aEvaluation Studies as Topic 606 $aTherapeutic Uses 606 $aDiseases 606 $aPharmacology 606 $aGenetics 606 $aInvestigative Techniques 606 $aPharmacologic Actions 606 $aTherapeutics 606 $aBiology 606 $aHealth Occupations 606 $aBiological Science Disciplines 606 $aChemical Actions and Uses 606 $aAnalytical, Diagnostic and Therapeutic Techniques and Equipment 606 $aNatural Science Disciplines 606 $aDisciplines and Occupations 606 $aChemicals and Drugs 606 $aOncology$2HILCC 606 $aMedicine$2HILCC 606 $aHealth & Biological Sciences$2HILCC 608 $aElectronic books. 615 0$aCancer$xChemotherapy 615 0$aCancer$xImmunotherapy 615 0$aAntineoplastic agents$xDevelopment 615 2$aPharmacogenetics 615 2$aAntineoplastic Agents 615 2$aDrug Delivery Systems 615 2$aDrug Evaluation 615 2$aNeoplasms 615 2$aDrug Therapy 615 2$aEvaluation Studies as Topic 615 2$aTherapeutic Uses 615 2$aDiseases 615 2$aPharmacology 615 2$aGenetics 615 2$aInvestigative Techniques 615 2$aPharmacologic Actions 615 2$aTherapeutics 615 2$aBiology 615 2$aHealth Occupations 615 2$aBiological Science Disciplines 615 2$aChemical Actions and Uses 615 2$aAnalytical, Diagnostic and Therapeutic Techniques and Equipment 615 2$aNatural Science Disciplines 615 2$aDisciplines and Occupations 615 2$aChemicals and Drugs 615 7$aOncology 615 7$aMedicine 615 7$aHealth & Biological Sciences 676 $a616.99/4061 702 $aPrendergast$b George C 801 0$bPQKB 906 $aBOOK 912 $a9910146065303321 996 $aMolecular cancer therapeutics : strategies for drug discovery and development$91985754 997 $aUNINA LEADER 04944nam 2201033Ia 450 001 996248202203316 005 20240410062621.0 010 $a9786612359705 010 $a0-520-93715-5 010 $a1-59734-773-6 010 $a1-282-35970-3 024 7 $a10.1525/9780520937154 035 $a(CKB)1000000000005542 035 $a(EBL)222990 035 $a(OCoLC)475926865 035 $a(SSID)ssj0000210353 035 $a(PQKBManifestationID)11912098 035 $a(PQKBTitleCode)TC0000210353 035 $a(PQKBWorkID)10283393 035 $a(PQKB)10819649 035 $a(OCoLC)55741763 035 $a(MdBmJHUP)muse30478 035 $a(DE-B1597)519347 035 $a(OCoLC)990750634 035 $a(DE-B1597)9780520937154 035 $a(Au-PeEL)EBL222990 035 $a(CaPaEBR)ebr10058536 035 $a(CaONFJC)MIL235970 035 $a(MiAaPQ)EBC222990 035 $a(dli)HEB08191 035 $a(MiU)MIU01000000000000009852076 035 $a(EXLCZ)991000000000005542 100 $a20040815d2004 my 0 101 0 $aeng 135 $aurun#---uu|uu 181 $ctxt 182 $cc 183 $acr 200 14$aThe new German cinema $emusic, history, and the matter of style /$fCaryl Flinn 205 $a1st ed. 210 $aBerkeley $cUniversity of California Press$dc2004 215 $a1 online resource (332 p.) 300 $aDescription based upon print version of record. 311 0 $a0-520-22895-2 311 0 $a0-520-23823-0 320 $aIncludes bibliographical references and index. 327 $tFront matter --$tContents --$tAcknowledgments --$tIntroduction: "Strategies Of Remembrance" --$t1. Mourning, Melancholia, And "New German Melodrama" --$t2. Modernism's Aftershocks: Peer Raben's Film Music For Fassbinder --$t3. Kluge's Assault On History: Trauma, Testimony, And Difference In The Patriot --$t4. Undoing Act 5: History, Bodies, And Operatic Remains: Kluge's The Power Of Emotion --$t5. Restaging History With Fantasy: Body, Camp, And Sound In The Films Of Treut, Ottinger, And Von Praunheim --$t6. Introjecting Kitsch: Werner Schroeter, Music, And Alterity --$tCoda: Working The Pieces --$tNotes --$tIndex 330 $aWhen New German cinema directors like R. W. Fassbinder, Ulrike Ottinger, and Werner Schroeter explored issues of identity-national, political, personal, and sexual-music and film style played crucial roles. Most studies of the celebrated film movement, however, have sidestepped the role of music, a curious oversight given its importance to German culture and nation formation. Caryl Flinn's study reverses this trend, identifying styles of historical remembrance in which music participates. Flinn concentrates on those styles that urge listeners to interact with difference-including that embodied in Germany's difficult history-rather than to "master" or "get past" it. Flinn breaks new ground by considering contemporary reception frameworks of the New German Cinema, a generation after its end. She discusses transnational, cultural, and historical contexts as well as the sexual, ethnic, national, and historical diversity of audiences. Through detailed case studies, she shows how music helps filmgoers engage with a range of historical subjects and experiences. Each chapter of The New German Cinema examines a particular stylistic strategy, assessing music's role in each. The study also examines queer strategies like kitsch and camp and explores the movement's charged construction of human bodies on which issues of ruination, survival, memory, and pleasure are played out. 606 $aMotion picture music$zGermany$xHistory and criticism 606 $aMotion pictures$zGermany 610 $acinema historians. 610 $acontemporary germany. 610 $afamous films. 610 $afilm buffs. 610 $afilm students. 610 $afilm styles. 610 $afilm textbooks. 610 $agerman cinema. 610 $agerman cinematic style. 610 $agerman culture. 610 $agerman directors. 610 $agerman music. 610 $agermany. 610 $ahistorical contexts. 610 $ahistorical review. 610 $akitsch. 610 $amusic styles. 610 $amusic. 610 $anational identity. 610 $anew german cinema. 610 $anonfiction. 610 $apersonal identity. 610 $apolitical identity. 610 $ar w fassbinder. 610 $asexual identity. 610 $atransnational contexts. 610 $aulrike ottinger. 610 $awerner schroeter. 615 0$aMotion picture music$xHistory and criticism. 615 0$aMotion pictures 676 $a791.43/657 700 $aFlinn$b Caryl$0792581 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996248202203316 996 $aThe new German cinema$92320195 997 $aUNISA