LEADER 03520nam 22006014a 450 001 9910145906203321 005 20170815114913.0 010 $a1-280-27158-2 010 $a9786610271580 010 $a0-470-66817-2 010 $a0-470-86257-2 010 $a0-470-86258-0 035 $a(CKB)1000000000018895 035 $a(EBL)191296 035 $a(OCoLC)475901122 035 $a(SSID)ssj0000196339 035 $a(PQKBManifestationID)11189569 035 $a(PQKBTitleCode)TC0000196339 035 $a(PQKBWorkID)10155336 035 $a(PQKB)10270027 035 $a(MiAaPQ)EBC191296 035 $a(EXLCZ)991000000000018895 100 $a20040107d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMammalian TRP channels as molecular targets$b[electronic resource] /$f[editors, Derek J. Chadwick (organizer) and Jamie A. Goode] 210 $aChichester, UK ;$aHoboken, NJ $cJohn Wiley & Sons$d2004 215 $a1 online resource (287 p.) 225 1 $aNovartis Foundation symposium ;$v258 300 $aProceedings of the Symposium on Mammalian TRP Channels as Molecular Targets, held at the Novartis Foundation, London, 25-27 March, 2003. 311 $a0-470-86254-8 320 $aIncludes bibliographical references and index. 327 $aMAMMALIAN TRP CHANNELS AS MOLECULAR TARGETS; Contents; Chair's introduction; Molecular genetics of Drosophila TRP channels; Discussion; Mammalian TRPC channel subunit assembly; Discussion; TRPC channel interactions with calmodulin and IP(3) receptors; Discussion; Plasma membrane localization of TRPC channels: role of caveolar lipid rafts; Discussion; Assembly and gating of TRPC channels in signalling microdomains; Discussion; General discussion I; Activation, subunit composition and physiological relevance of DAG-sensitive TRPC proteins; Discussion; Signalling mechanisms for TRPC3 channels 327 $aDiscussionDiversity of TRP channel activation; Discussion; General discussion II; Regulation of Drosophila TRP channels by lipid messengers; Discussion; Control of TRPC and store-operated channels by protein kinase C; Discussion; TRPC4 and TRPC4 deficient mice; Discussion; TRP channels as drug targets; Discussion; Role of TRP channels in oxidative stress; Discussion; Distribution of TRPC channels in a visceral sensory pathway; Discussion; Emerging roles of TRPM channels; Discussion; Final discussion; Index of contributors; Subject index 330 $aThis book brings together contributions from key investigators in the area of Transient Receptor Potential (TRP) channel structure and function. It covers the structure, function and regulation of mammalian TRP channels and mechanisms of signal transduction. The discussions indicate research that would improve understanding of the role of TRP channels in normal cellular physiology, the involvement of TRP channels in disease states and their potential use as molecular targets for novel therapeutic agents. 410 0$aNovartis Foundation symposium ;$v258. 606 $aTRP channels$vCongresses 608 $aElectronic books. 615 0$aTRP channels 676 $a571.6/4 676 $a571.64 701 $aChadwick$b Derek$091632 701 $aGoode$b Jamie$0283336 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910145906203321 996 $aMammalian TRP channels as molecular targets$92149284 997 $aUNINA