LEADER 04669nam 2200661Ia 450 001 9910455752103321 005 20200520144314.0 010 $a0-674-03935-1 024 3 $a9780674019911 035 $a(CKB)2440000000013075 035 $a(StDuBDS)AH23050757 035 $a(SSID)ssj0000172422 035 $a(PQKBManifestationID)12038564 035 $a(PQKBTitleCode)TC0000172422 035 $a(PQKBWorkID)10171441 035 $a(PQKB)10061167 035 $a(SSID)ssj0000484987 035 $a(PQKBManifestationID)11344232 035 $a(PQKBTitleCode)TC0000484987 035 $a(PQKBWorkID)10612027 035 $a(PQKB)11657206 035 $a(MiAaPQ)EBC3300302 035 $a(WaSeSS)bw9780674019911 035 $a(Au-PeEL)EBL3300302 035 $a(CaPaEBR)ebr10314314 035 $a(OCoLC)923110446 035 $a(DE-B1597)574330 035 $a(DE-B1597)9780674039353 035 $a(EXLCZ)992440000000013075 100 $a20040511d2004 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aHitler Youth$b[electronic resource] /$fMichael H. Kater 205 $aAnnotated 210 $aCambridge, MA $cHarvard University Press$d2004 215 $a1 online resource (355 p.) 300 $aOriginally published: 2004. 311 $a0-674-01496-0 311 $a0-674-01991-1 320 $aIncludes bibliographical references (p. [271]-345) and index. 327 $tFrontmatter -- $tContents -- $t1 ?Make Way, You Old Ones!? -- $t2 Serving in the Hitler Youth -- $tIntroduction -- $tIn Search of Monopoly and Uniformity -- $tAuthoritarianism, Militarism, Imperialism -- $tProblems of Training, Discipline, and Leadership -- $t3 German Girls for Matrimony and Motherhood -- $tIntroduction -- $tThe Bund Deutscher Mädel in Peacetime -- $tThe Challenges of World War II -- $tEugenics and Race -- $t4 Dissidents and Rebels -- $tIntroduction -- $tThe Varieties of Dissidence -- $tThe Empire Strikes Back -- $t5 Hitler?s Youth at War -- $tIntroduction -- $tElation and Disenchantment -- $tDetours, Duplications, and Alternatives -- $tThe Final Victory -- $tHitler?s Young Women Deceived -- $t6 The Responsibility of Youth -- $tAbbreviations -- $tNotes -- $tAcknowledgments -- $tIndex 330 8 $aThe recruitment of children into a political organization and ideology reached its boldest embodiment in the Hitler Youth, founded in 1933. Michael Kater traces the history of Hitler Youth, examining the means, degree, and impact of conversation, and the subsequent fate of young recruits.$bIn modern times, the recruitment of children into a political organization and ideology reached its boldest embodiment in the Hitler Youth, founded in 1933 soon after the Nazi Party assumed power in Germany. Determining that by age ten children's minds could be turned from play to politics, the regime inducted nearly all German juveniles between the ages of ten and eighteen into its state-run organization. The result was a potent tool for bending young minds and hearts to the will of Adolf Hitler. Baldur von Schirach headed a strict chain of command whose goal was to shift the adolescents' sense of obedience from home and school to the racially defined Volk and the Third Reich. Luring boys and girls into Hitler Youth ranks by offering them status, uniforms, and weekend hikes, the Nazis turned campgrounds into premilitary training sites, air guns into machine guns, sing-alongs into marching drills, instruction into indoctrination, and children into Nazis. A few resisted for personal or political reasons, but the overwhelming majority enlisted. Drawing on original reports, letters, diaries, and memoirs, Kater traces the history of the Hitler Youth, examining the means, degree, and impact of conversion, and the subsequent fate of young recruits. Millions of Hitler Youth joined the armed forces; thousands gleefully participated in the subjugation of foreign peoples and the obliteration of "racial aliens." Although young, they committed crimes against humanity for which they cannot escape judgment. Their story stands as a harsh reminder of the moral bankruptcy of regimes that make children complicit in crimes of the state. 606 $aNational socialism and youth 607 $aGermany$xHistory$y1933-1945 608 $aElectronic books. 615 0$aNational socialism and youth. 676 $a943.0860835 700 $aKater$b Michael H.$f1937-$0865356 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910455752103321 996 $aHitler Youth$92454265 997 $aUNINA LEADER 03625nam 2200853 450 001 9910821501003321 005 20170919032824.0 010 $a1-78238-737-4 024 7 $a10.1515/9781782387374 035 $a(CKB)3710000000484740 035 $a(EBL)4000014 035 $a(SSID)ssj0001562935 035 $a(PQKBManifestationID)16211286 035 $a(PQKBTitleCode)TC0001562935 035 $a(PQKBWorkID)14826452 035 $a(PQKB)10646974 035 $a(MiAaPQ)EBC4000014 035 $a(DE-B1597)636153 035 $a(DE-B1597)9781782387374 035 $a(EXLCZ)993710000000484740 100 $a20151111h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFigurations of the future $eforms and temporalities of left radical politics in Northern Europe /$fby Stine Krĝijer 210 1$aNew York ;$aOxford, [England] :$cBerghahn,$d2015. 210 4$dİ2015 215 $a1 online resource (256 p.) 225 1 $aEthnography, Theory, Experiment ;$vVolume 2 300 $aDescription based upon print version of record. 311 $a1-78238-736-6 320 $aIncludes bibliographical references and index. 327 $a'Other Worlds Are Possible' : A Political Cosmology of Capitalism -- Becoming Absorbed : Youth and Interstices of Active Time in Ungdomshuset -- 'A Common Choreography of Action' : Preparations and Intentions -- 'We Are Humans, What Are You?' : Securitization, Unpredictability and Enemy-Becoming -- 'I Used To Run As The Black Bloc' : Style and Perspectivist Time in Protests and Direct Actions -- Conclusion : The Collective Body as a Theory of Politics. 330 $aBuilt around key events, from the eviction of a self-managed social centre in Copenhagen in 2007 to the Climate Summit protests in 2009, this book contributes to anthropological literature on contemporary Euro-American politics foreshadowing recent waves of public dissent. Stine Krĝijer explores political forms among left radical and anarchist activists in Northern Europe focusing on how forms of action engender time. Drawing on anthropological literature from both Scandinavia and the Amazon, this ethnography recasts theoretical concerns about body politics, political intentionality, aesthetics, and time. 410 0$aEthnography, theory, experiment ;$vVolume 2. 606 $aRadicalism$zEurope, Northern 606 $aNew Left$zEurope, Northern 606 $aProtest movements$zEurope, Northern 607 $aEurope, Northern$xPolitics and government$y21st century 610 $a2007 to 2009. 610 $aaesthetics. 610 $aamazon. 610 $aamerican politics. 610 $aanarchist activists. 610 $aanthropological literature. 610 $abody politics. 610 $acopenhagen. 610 $adifferent forms of action. 610 $aethnography. 610 $aeuropean politics. 610 $aleft radicalists. 610 $anorthern europe. 610 $apolitical ideologies. 610 $apolitical intentionality. 610 $apublic dissent. 610 $ascandinavia. 610 $asocial centre. 610 $atheoretical concerns. 610 $atime. 615 0$aRadicalism 615 0$aNew Left 615 0$aProtest movements 676 $a320.530948 686 $aLB 49205$2rvk 700 $aKrĝijer$b Stine$01665585 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910821501003321 996 $aFigurations of the future$94024305 997 $aUNINA LEADER 05463nam 22007094a 450 001 9910145814603321 005 20200520144314.0 010 $a9786612267833 010 $a9781282267831 010 $a1282267833 010 $a9780470451854 010 $a0470451858 010 $a9780470451847 010 $a047045184X 035 $a(CKB)1000000000715904 035 $a(EBL)416234 035 $a(SSID)ssj0000127579 035 $a(PQKBManifestationID)11147624 035 $a(PQKBTitleCode)TC0000127579 035 $a(PQKBWorkID)10052992 035 $a(PQKB)11625150 035 $a(Au-PeEL)EBL416234 035 $a(CaPaEBR)ebr10297805 035 $a(CaONFJC)MIL226783 035 $a(PPN)243326491 035 $a(FINmELB)ELB178990 035 $a(OCoLC)352838369 035 $a(MiAaPQ)EBC416234 035 $a(Perlego)2756810 035 $a(EXLCZ)991000000000715904 100 $a20080923d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aComputational drug design $ea guide for computational and medicinal chemists /$fDavid C. Young 205 $a1st ed. 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2009 215 $a1 online resource (xxxvi, 307 pages) $cillustrations 311 08$a9780470126851 311 08$a047012685X 320 $aIncludes bibliographical references and index. 327 $aCOMPUTATIONAL DRUG DESIGN; CONTENTS; PREFACE; ACKNOWLEDGMENTS; ABOUT THE AUTHOR; SYMBOLS USED IN THIS BOOK; BOOK ABSTRACT; 1 Introduction; 1.1 A Difficult Problem; 1.2 An Expensive Problem; 1.3 Where Computational Techniques are Used; Bibliography; PART I THE DRUG DESIGN PROCESS; 2 Properties that Make a Molecule a Good Drug; 2.1 Compound Testing; 2.1.1 Biochemical Assays; 2.1.2 Cell-Based Assays; 2.1.3 Animal Testing; 2.1.4 Human Clinical Trials; 2.2 Molecular Structure; 2.2.1 Activity; 2.2.2 Bioavailability and Toxicity; 2.2.3 Drug Side Effects; 2.2.4 Multiple Drug Interactions 327 $a2.3 Metrics for Drug-Likeness; 2.4 Exceptions to the Rules; Bibliography; 3 Target Identification; 3.1 Primary Sequence and Metabolic Pathway; 3.2 Crystallography; 3.3 2D NMR; 3.4 Homology Models; 3.5 Protein Folding; Bibliography; 4 Target Characterization; 4.1 Analysis of Target Mechanism; 4.1.1 Kinetics and Crystallography; 4.1.2 Automated Crevice Detection; 4.1.3 Transition Structures and Reaction Coordinates; 4.1.4 Molecular Dynamics Simulations; 4.2 Where the Target is Expressed; 4.3 Pharmacophore Identification; 4.4 Choosing an Inhibitor Mechanism; Bibliography 327 $a5 The Drug Design Process for a Known Protein Target; 5.1 The Structure-Based Design Process; 5.2 Initial Hits; 5.3 Compound Refinement; 5.4 ADMET; 5.5 Drug Resistance; Bibliography; 6 The Drug Design Process for an Unknown Target; 6.1 The Ligand-Based Design Process; 6.2 Initial Hits; 6.3 Compound Refinement; 6.4 ADMET; Bibliography; 7 Drug Design for Other Targets; 7.1 DNA Binding; 7.2 RNA as a Target; 7.3 Allosteric Sites; 7.4 Receptor Targets; 7.5 Steroids; 7.6 Targets inside Cells; 7.7 Targets within the Central Nervous System; 7.8 Irreversibly Binding Inhibitors 327 $a7.9 Upregulating Target Activity; Bibliography; 8 Compound Library Design; 8.1 Targeted Libraries versus Diverse Libraries; 8.2 From Fragments versus from Reactions; 8.3 Non-Enumerative Techniques; 8.4 Drug-Likeness and Synthetic Accessibility; 8.5 Analyzing Chemical Diversity and Spanning known Chemistries; 8.6 Compound Selection Techniques; Bibliography; PART II COMPUTATIONAL TOOLS AND TECHNIQUES; 9 Homology Model Building; 9.1 How much Similarity is Enough?; 9.2 Steps for Building a Homology Model; 9.2.1 Step 1: Template Identification 327 $a9.2.2 Step 2: Alignment between the Unknown and the Template; 9.2.3 Step 3: Manual Adjustments to the Alignment; 9.2.4 Step 4: Replace Template Side Chains with Model Side Chains; 9.2.5 Step 5: Adjust Model for Insertions and Deletions; 9.2.6 Step 6: Optimization of the Model; 9.2.7 Step 7: Model Validation; 9.2.8 Step 8: If Errors are Found, Iterate Back to Previous Steps; 9.3 Reliability of Results; Bibliography; 10 Molecular Mechanics; 10.1 A Really Brief Introduction to Molecular Mechanics; 10.2 Force Fields for Drug Design; Bibliography; 11 Protein Folding; 11.1 The Difficulty of the Problem 330 $aHelps you choose the right computational tools and techniques to meet your drug design goals Computational Drug Design covers all of the major computational drug design techniques in use today, focusing on the process that pharmaceutical chemists employ to design a new drug molecule. The discussions of which computational tools to use and when and how to use them are all based on typical pharmaceutical industry drug design processes. Following an introduction, the book is divided into three parts: Part One, The Drug Design Process, sets forth a variety of design processes 606 $aDrugs$xDesign$xMathematical models 606 $aDrugs$xDesign$xData processing 615 0$aDrugs$xDesign$xMathematical models. 615 0$aDrugs$xDesign$xData processing. 676 $a615/.190285 700 $aYoung$b David C.$f1964-$0514308 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910145814603321 996 $aComputational Drug Design$9852152 997 $aUNINA LEADER 05746nam 2200769 a 450 001 9910966733803321 005 20240501134906.0 010 $a9786612359279 010 $a9781282359277 010 $a1282359274 010 $a9780520933828 010 $a0520933826 024 7 $a10.1525/9780520933828 035 $a(CKB)1000000000807790 035 $a(EBL)470991 035 $a(OCoLC)609850138 035 $a(SSID)ssj0000310054 035 $a(PQKBManifestationID)11224558 035 $a(PQKBTitleCode)TC0000310054 035 $a(PQKBWorkID)10287421 035 $a(PQKB)11006155 035 $a(StDuBDS)EDZ0000055788 035 $a(MiAaPQ)EBC470991 035 $a(OCoLC)752326738 035 $a(MdBmJHUP)muse30712 035 $a(DE-B1597)520562 035 $a(OCoLC)503050209 035 $a(DE-B1597)9780520933828 035 $a(Au-PeEL)EBL470991 035 $a(CaPaEBR)ebr10676181 035 $a(CaONFJC)MIL235927 035 $a(Perlego)2319559 035 $a(EXLCZ)991000000000807790 100 $a20070806d2008 uy 0 101 0 $aeng 135 $aur|||||||nn|n 181 $ctxt 182 $cc 183 $acr 200 00$aSpecialization, speciation, and radiation $ethe evolutionary biology of herbivorous insects /$fedited by Kelley Jean Tilmon 205 $a1st ed. 210 $aBerkeley $cUniversity of California Press$d2008 215 $a1 online resource (360 p.) 300 $aDescription based upon print version of record. 311 08$a9780520251328 311 08$a0520251326 320 $aIncludes bibliographical references and index. 327 $tChemical mediation of host-plant specialization : the papilionid paradigm /$rMay R. Berenbaum and Paul P. Feeny --$tEvolution of preference and performance relationships /$rTimothy P. Craig and Joanne K. Itami --$tEvolutionary ecology of polyphagy /$rMichael S. Singer --$tPhenotypic plasticity /$rKailen A. Mooney and Anurag A. Agrawal --$tSelection and genetic architecture of plant resistance /$rMary Ellen Czesak, Robert S. Fritz, and Cris Hochwender --$tIntrogression and parapatric speciation in a hybrid zone /$rJ. Mark Scriber, Gabe J. Ording, and Rodrigo J. Mercader --$tHost shifts, the evolution of communication, and speciation in the Enchenopa binotata species complex of treehoppers /$rReginald B. Cocroft, Rafael L. Rodri?guez, and Randy E. Hunt --$tHost fruit-odor discrimination and sympatric host-race formation /$rJeffrey L. Feder and Andrew A. Forbes --$tComparative analyses of ecological speciation /$rDaniel J. Funk and Patrik Nosil --$tSympatric speciation : norm or exception? /$rDouglas J. Futuyma -- 327 $tHost-plant use, diversification, and coevolution : insights from remote Oceanic islands /$rGeorge K. Roderick and Diana M. Percy --$tSelection by pollinators and herbivores on attraction and defense /$rLynn S. Adler --$tAdaptive radiation : phylogenetic constraints and ecological consequences /$rPeter W. Price --$tSequential radiation through host-race formation : herbivore diversity leads to diversity in natural enemies /$rWarren G. Abrahamson and Catherine P. Blair --$tThe oscillation hypothesis of host-plant range and speciation /$rNiklas Janz and So?ren Nylin --$tCoevolution, cryptic speciation, and the persistence of interactions /$rJohn N. Thompson --$tCophylogeny of figs, pollinators, gallers, and parasitoids /$rSummer I. Silvieus, Wendy L. Clement, and George D. Weiblen --$tThe phylogenetic dimension of insect-plant interactions : a review of recent evidence /$rIsaac S. Winkler and Charles Mitter --$tEvolution of insect resistance to transgenic plants /$rBruce E. Tabashnik and Yves Carrie?re --$tExotic plants and enemy resistance /$rJohn L. Maron and Montserrat Vila? --$tLife-history evolution in native and introduced populations /$rRobert F. Denno ... [et al.] --$tRapid natural and anthropogenic diet evolution : three examples from checkerspot butterflies /$rMichael C. Singer ... [et al.] --$tConservation of coevolved insect herbivores and plants /$rCarol L. Boggs and Paul R. Ehrlich. 330 $aThe intimate associations between plants and the insects that eat them have helped define and shape both groups for millions of years. This pioneering volume is a comprehensive, up-to-date treatment of the evolutionary biology of herbivorous insects, including their relationships with host plants and natural enemies. Chapters focus on the dynamic relationships between insects and plants from the standpoint of evolutionary change at different levels of biological organization-individuals, populations, species, and clades. Written by prominent evolutionary biologists, entomologists, and ecologists, the chapters are organized into three sections: Evolution of Populations and Species; Co- and Macroevolutionary Radiation; and Evolutionary Aspects of Pests, Invasive Species, and the Environment. The volume is unified by the idea that understanding the ecological framework of the interactions between herbivorous insects and their host plants is fundamental to understanding their evolution. 517 3 $aEvolutionary biology of herbivorous insects 606 $aPhytophagous insects$xEvolution 606 $aPhytophagous insects$xBehavior 606 $aInsect-plant relationships 615 0$aPhytophagous insects$xEvolution. 615 0$aPhytophagous insects$xBehavior. 615 0$aInsect-plant relationships. 676 $a595.7138 686 $aWQ 3074$2rvk 701 $aTilmon$b Kelley Jean$01813479 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910966733803321 996 $aSpecialization, speciation, and radiation$94366645 997 $aUNINA