LEADER 05298nam 2200685Ia 450 001 9910145696303321 005 20230721031355.0 010 $a1-281-28520-X 010 $a9786611285203 010 $a0-470-28317-3 010 $a0-470-28316-5 035 $a(CKB)1000000000414762 035 $a(EBL)335785 035 $a(OCoLC)476150908 035 $a(SSID)ssj0000112186 035 $a(PQKBManifestationID)11134277 035 $a(PQKBTitleCode)TC0000112186 035 $a(PQKBWorkID)10085640 035 $a(PQKB)11759458 035 $a(MiAaPQ)EBC335785 035 $a(Au-PeEL)EBL335785 035 $a(CaPaEBR)ebr10296489 035 $a(CaONFJC)MIL128520 035 $a(EXLCZ)991000000000414762 100 $a20071114d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBiomedical vibrational spectroscopy$b[electronic resource] /$fedited by Peter Lasch, Janina Kneipp 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2008 215 $a1 online resource (403 p.) 300 $aDescription based upon print version of record. 311 $a0-470-22945-4 320 $aIncludes bibliographical references and index. 327 $aBIOMEDICAL VIBRATIONAL SPECTROSCOPY; CONTENTS; Preface; Contributors; 1 VIBRATIONAL SPECTROSCOPY IN MICROBIOLOGY AND MEDICAL DIAGNOSTICS; 1.1 Vibrational Spectra in Biomedicine Provide Fingerprint-like Signatures of Biological Structures; 1.2 Different Technical Options to Obtain the Spectral Information; 1.3 The Need for and Benefit from Data Evaluation; 1.4 Perspectives of Biomedical Vibrational Spectroscopy; 2 BIOMEDICAL VIBRATIONAL SPECTROSCOPY - TECHNICAL ADVANCES; 2.1 Introduction; 2.2 Measurement Techniques for Clinical Chemistry; 2.3 Measurement Techniques for Pathology 327 $a2.4 Measurement Techniques for In Vivo Spectroscopy2.5 Concluding Remarks; Acknowledgments; References; 3 BIOMEDICAL APPLICATIONS OF INFRARED MICROSPECTROSCOPY AND IMAGING BY VARIOUS MEANS; 3.1 Introduction; 3.2 Specimen Sources, Experimental Schemes, and Optical Substrates; 3.3 Applications; 3.4 Instrumental Means of Biomedical IMS; 3.5 Comment; Acknowledgments; Acronyms and Trademarks; References; 4 INFRARED SPECTROSCOPY OF BIOFLUIDS IN CLINICAL CHEMISTRY AND MEDICAL DIAGNOSTICS; 4.1 Introduction; 4.2 Vibrational Spectroscopy of Biofluids 327 $a4.3 Quantification (Regression) and Diagnostic (Classification) Approaches4.4 Quantitative Biofluid Analysis; 4.5 Diagnostic Biofluid Tests; 4.6 Veterinary Applications; 4.7 Microfluidics and IR Spectroscopy of Biofluids; 4.8 Concluding Remarks; References; 5 RAMAN SPECTROSCOPY OF BIOFLUIDS; 5.1 Introduction; 5.2 Background Fluorescence; 5.3 The Putative Drawback of a Low Signal-to-Noise-Ratio; 5.4 Spectroscopy of Blood and Its Derivates; 5.5 In Vitro Raman Spectroscopy of Serum for Laboratory Diagnostics: A Case Study; 5.6 Raman Spectroscopy of Body Fluids In Vivo 327 $a5.7 Raman Spectroscopy of Other Body Fluids5.8 Summary; Acknowledgments; References; 6 VIBRATIONAL MICROSPECTROSCOPY OF CELLS AND TISSUES; 6.1 Introduction; 6.2 Infrared Histopathology: IR Microspectroscopic Mapping of Tissues; 6.3 Vibrational Cytology: IR and Raman Spectroscopy of Eukaryotic Cells; 6.4 Concluding Remarks; Acknowledgments; References; 7 RESONANCE RAMAN MICROSPECTROSCOPY AND IMAGING OF HEMOPROTEINS IN SINGLE LEUKOCYTES; 7.1 Hemoproteins; 7.2 Raman Microspectroscopy; 7.3 Outline of This Chapter; 7.4 Instrumentation and Spectral Data Analysis 327 $a7.5 Resonance Raman Microspectroscopy on Neutrophilic Granulocytes7.6 Resonance Raman Microscopy on Neutrophilic Granulocytes; 7.7 Photobleaching and Light-Induced Cell Damage in Resonance Raman Microspectroscopy; 7.8 Concluding Remarks; Acknowledgments; References; 8 RESONANT RAMAN SCATTERING OF HEME MOLECULES IN CELLS AND IN THE SOLID STATE; 8.1 Introduction; 8.2 Electronic Structure of Heme Moieties; 8.3 Resonance Raman Spectroscopy; 8.4 Resonance Raman Spectroscopy of Hemes in Cells and the Solid State 327 $a8.5 Resonance Raman of Heme Derivatives Using Near-Infrared Excitation in the Solid State 330 $aThis comprehensive overview of biomedical applications of vibrational spectroscopy focuses on methodologies that are most relevant to biodiagnostics. After a few introductory chapters that summarize the current status of the field, the reference covers current spectroscopic applications; new spectroscopic directions; and study design and the analysis of vibrational spectral fingerprints from complex biological and clinical samples . With chapters contributed by leading international experts, Biomedical Vibrational Spectroscopy is a core resource. 606 $aDiagnostic imaging 606 $aInfrared spectroscopy 606 $aRaman spectroscopy 615 0$aDiagnostic imaging. 615 0$aInfrared spectroscopy. 615 0$aRaman spectroscopy. 676 $a535.8/42 676 $a535.842 701 $aKneipp$b Janina$0904920 701 $aLasch$b Peter$0904921 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910145696303321 996 $aBiomedical vibrational spectroscopy$92023624 997 $aUNINA