LEADER 00982nam0-22003011i-450- 001 990000689180403321 005 20001010 035 $a000068918 035 $aFED01000068918 035 $a(Aleph)000068918FED01 035 $a000068918 100 $a20001010d--------km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aECONOMIES et societes$ecahiers de l' Istitut de science economique appliquee, Laboratoire du College de France associeau C.N.R.S. 210 $aGeneve$cEd. Droz$d1967- 215 $av.$d22 cm 225 1 $aCahiers de l' I.S.E.A. 300 $a6.: Economie regionale . - Geneve : Ed. Droz, 1968. - 1316 p.; 22 cm. - (Cahiers de l'I.S.E.A.; 6) 712 02$aInstitut de science économique appliquée$c 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990000689180403321 952 $a01 L 2047$b2555$fDINST 959 $aDINST 996 $aECONOMIES et societes$9324552 997 $aUNINA DB $aING01 LEADER 02120nam 2200409z- 450 001 9910346750303321 005 20210212 035 $a(CKB)4920000000094211 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/59417 035 $a(oapen)doab59417 035 $a(EXLCZ)994920000000094211 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aSingle-Domain Antibodies: Biology, Engineering and Emerging Applications 210 $cFrontiers Media SA$d2018 215 $a1 online resource (338 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-432-0 330 $aSingle-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics. 517 $aSingle-Domain Antibodies 606 $aMedicine and Nursing$2bicssc 610 $aantibody discovery 610 $aantibody engineering 610 $adiagnostic antibody 610 $asingle-domain antibody 610 $atherapeutic antibody 615 7$aMedicine and Nursing 700 $aKevin A. Henry$4auth$01279436 702 $aC. Roger MacKenzie$4auth 906 $aBOOK 912 $a9910346750303321 996 $aSingle-Domain Antibodies: Biology, Engineering and Emerging Applications$93015375 997 $aUNINA LEADER 01975oas 2200805 a 450 001 9910145345503321 005 20251106213014.0 011 $a1998-3573 035 $a(DE-599)ZDB2270267-2 035 $a(OCoLC)225391586 035 $a(CONSER) 2010262128 035 $a(CKB)1000000000277406 035 $a(EXLCZ)991000000000277406 100 $a20070504a20049999 oy 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aHepatitis B annual /$fKalinga Gastroenterology Foundation 210 $aMumbai, India $cWolters Kluwer - Medknow$d[2004]- 215 $a1 online resource 300 $aRefereed/Peer-reviewed 311 08$a0972-9747 606 $aHepatitis B virus$vPeriodicals 606 $aHepatitis B$vPeriodicals 606 $aHepatitis B virus 606 $aHepatitis B 606 $aHepatitis B$2fast$3(OCoLC)fst00955199 606 $aHepatitis B virus$2fast$3(OCoLC)fst00955211 608 $aPeriodical. 608 $aPeriodicals.$2fast 615 0$aHepatitis B virus 615 0$aHepatitis B 615 12$aHepatitis B virus. 615 22$aHepatitis B. 615 7$aHepatitis B. 615 7$aHepatitis B virus. 712 02$aKalinga Gastroenterology Foundation 801 0$bAU@ 801 1$bAU@ 801 2$bOCLCQ 801 2$bCGU 801 2$bCUS 801 2$bSFB 801 2$bCEF 801 2$bHTM 801 2$bCUI 801 2$bOCLCQ 801 2$bOCLCF 801 2$bOCLCQ 801 2$bOCLCO 801 2$bOCLCA 801 2$bCRU 801 2$bMOW 801 2$bWYU 801 2$bOCLCO 801 2$bOCLCA 801 2$bVT2 801 2$bNLM 801 2$bOCLCO 801 2$bOCLCA 801 2$bOCLCQ 801 2$bIOY 801 2$bOCLCL 801 2$bOCLCQ 906 $aJOURNAL 912 $a9910145345503321 996 $aHepatitis B annual$91914687 997 $aUNINA