LEADER 05168nam 2200661Ia 450 001 9910145254203321 005 20200520144314.0 010 $a9786612021640 010 $a9781282021648 010 $a1282021648 010 $a9783527626236 010 $a3527626239 010 $a9783527626243 010 $a3527626247 035 $a(CKB)1000000000707620 035 $a(EBL)481909 035 $a(SSID)ssj0000117859 035 $a(PQKBManifestationID)11143712 035 $a(PQKBTitleCode)TC0000117859 035 $a(PQKBWorkID)10049305 035 $a(PQKB)10690198 035 $a(MiAaPQ)EBC481909 035 $a(OCoLC)352832572 035 $a(Perlego)2753897 035 $a(EXLCZ)991000000000707620 100 $a20080402d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCardiovascular hormone systems /$fedited by Michael Bader 210 $aWeinheim $cWiley-VCH$dc2008 215 $a1 online resource (459 p.) 300 $aDescription based upon print version of record. 311 08$a9783527319206 311 08$a3527319204 320 $aIncludes bibliographical references and index. 327 $aCardiovascular Hormone Systems; Contents; Preface; List of Contributors; Part One: Steroid Hormones; 1: Glucocorticoids and Mineralocorticoids; 1.1 Synthesis of the Corticosteroids; 1.2 Regulation of Corticosteroid Synthesis; 1.2.1 Aldosterone; 1.2.2 Glucocorticoids; 1.3 Corticosteroid Receptors and Control of Ligand Access; 1.3.1 Steroid Receptors; 1.3.2 Control of Ligand Access; 1.3.2.1 11BHSD1; 1.3.2.2 11BHSD2; 1.4 Cardiovascular Effects of Aldosterone; 1.4.1 Aldosterone and the Heart; 1.4.2 Vasculature; 1.5 Cardiovascular Effects of Glucocorticoids; 1.5.1 Transgenic Models 327 $a1.5.2 Lessons from Human Disease1.5.2.1 Cushing's Syndrome; 1.5.2.2 The Metabolic Syndrome and Tissue-Specific Regulation of Glucocorticoids; 1.5.2.3 Glucocorticoid Resistance Syndrome; 1.5.2.4 GR Polymorphisms; 1.5.3 Endothelial Dysfunction, Vascular Tone and Atherosclerosis; References; 2: Sex Steroid Hormones; 2.1 Sex Differences in Cardiovascular Physiology and Disease and Effect of Hormone Therapy; 2.2 Sex Steroids: Estradiol, Estrone, Testosterone and Progesterone; 2.2.1 Synthesis and Endocrine Physiology; 2.2.2 Age-Dependent Blood Levels of Sex Hormones in Females and Males 327 $a2.2.3 Levels of Estradiol and Testosterone in Rodents2.3 Sex Hormone Receptors: Structure and Function; 2.3.1 Hormone Response Elements; 2.3.2 Molecular Mechanisms of Nuclear Receptor Activation; 2.3.2.1 Ligand-Dependent Transcription; 2.3.2.2 Ligand-Independent Genomic Pathway: Cross-Talk Between SHR s and Other Signal Transduction Pathways; 2.3.2.3 Nongenomic Pathway; 2.3.3 Role of Coregulators in Transcriptional Regulation by SHRs; 2.3.4 Role of Proteasomal Degradation Pathway in SHR-Mediated Gene Transcription; 2.3.5 Receptor Activity and Availability in the Cardiovascular System 327 $a2.3.6 Localization of SHRs in the Heart and Vessels of Rodent and Men2.4 Receptor-Independent Effects of Sex Steroids; 2.5 Sex Hormone Effects on Cardiovascular Cells and Organs; 2.5.1 Sex Hormone Effects on Different Cardiovascular Cell Types; 2.5.1.1 Cardiomyocytes; 2.5.1.2 Fibroblasts; 2.5.1.3 Endothelial Cells; 2.5.1.4 Vascular Smooth Muscle Cells; 2.5.1.5 Platelets; 2.5.2 Sex Hormone Effects on the Heart; 2.5.2.1 Effects of Exercise; 2.5.2.2 Pressure Overload; 2.5.2.3 Hypertension; 2.5.2.4 Volume Overload; 2.5.2.5 Myocardial Infarction 327 $a2.5.3 Sex Hormone Effects on Atherosclerosis, Plaque Formation and Rupture2.5.4 Sex Hormone Effects on Systemic and Circulating Mediators of the Cardiovascular System; 2.5.4.1 Lipid Levels; 2.5.4.2 Glucose and Insulin; 2.5.4.3 Blood Pressure; 2.5.4.4 Coagulatory Activity; References; Part Two: Peptide Hormones; 3: Angiotensins; 3.1 Introduction; 3.2 RAS: The Classical and Updated View; 3.3 New Aspects of Classical RAS Enzymes; 3.3.1 Renin/Prorenin Receptor; 3.3.2 Signaling Through ACE; 3.4 Ang II; 3.4.1 Ang II and the Cardiovascular System; 3.4.2 Ang II and the Endocrine System 327 $a3.4.3 Ang II and the Renal System 330 $aEdited by a renowned scientist in the field with more than 200 high profile scientific publications to his name, this is the first book to provide a comprehensive overview of all cardiovascular hormone systems. Clearly structured, the text covers steroid and peptide hormones, amines, and arachidonic acid metabolites, as well as such others as nucleotides, nitric oxide, and acetylcholine. An essential reference for researchers working on the cardiovascular system and related diseases. 606 $aCardiovascular system$xDiseases$xEndocrine aspects 606 $aHormones 615 0$aCardiovascular system$xDiseases$xEndocrine aspects. 615 0$aHormones. 676 $a616.1 701 $aBader$b Michael$0997921 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910145254203321 996 $aCardiovascular hormone systems$92288685 997 $aUNINA