LEADER 04504nam 2200649 a 450 001 9910144848503321 005 20170810195502.0 010 $a1-280-76875-4 010 $a9786613679529 010 $a0-470-71925-7 010 $a0-470-71676-2 035 $a(CKB)1000000000687683 035 $a(EBL)703771 035 $a(OCoLC)775867436 035 $a(SSID)ssj0000715178 035 $a(PQKBManifestationID)11434928 035 $a(PQKBTitleCode)TC0000715178 035 $a(PQKBWorkID)10700526 035 $a(PQKB)11300350 035 $a(MiAaPQ)EBC703771 035 $a(EXLCZ)991000000000687683 100 $a19840321d1962 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCiba Foundation Symposium, jointly with Co-ordinating Committee for Symposia on Drug Action, on Enzymes and Drug Action$b[electronic resource] /$feditor for the Co-ordinating Committee, J.L. Mongar ; editor for the Ciba Foundation, A.V.S. de Reuck 210 $aBoston $cLittle, Brown$d1962 215 $a1 online resource (581 p.) 225 1 $aCiba Foundation symposium 300 $aDescription based upon print version of record. 311 $a0-470-72269-X 320 $aIncludes bibliographical references and indexes. 327 $aENZYMES AND DRUG ACTION; CONTENTS; Wellcome Building Sessions; Session 1: Enzymes as Primary Points of Drug Action; Chairman's introduction; Inhibition of acetylcholinesterase; Discussion; Carbonic anhydrase inhibition and physiological function; Discussion; Session 2: Active Transport; Pinocytosis; Discussion; Possible mechanisms of active transport; Discussion; Effects of drugs on active transport; Discussion; Session 3: Multiple Mechanisms; I. Insulin; The explanation of the action of insulin on sugar permeability at molecular level; Action of insulin on metabolic reactions; Discussion 327 $aII. DigitalisAction of cardiac glycosides on ionic movements; Digitalis: action on metabolism and the contractile system; Discussion; III. Central Nervous System Depressants; Action of barbiturates upon respiratory enzymes; Appraising enzymic actions of central depressants by examining cerebral tissues; Discussion; Session 4: Receptors; Relation between enzymes and cholinergic receptors; Discussion; Induction of receptors; Discussion; Session 5: Altered Drug Metabolism; Chairman's introduction; Adaptive enzymes in animals; Discussion; Drug tolerance; Discussion 327 $aThe genetics of drug sensitivity with special reference to suxamethoniumDiscussion; Session 6: Drug Metabolism: Subcellular Aspects; Drug metabolism-subcellular mechanisms; Discussion; Cellular injury by drugs; Protection against cellular injury by drugs; Discussion; Panel Discussion; Ciba Foundation Sessions on Drug-Enzyme Interaction at the Molecular Level; Session 1: Enzymes; Introduction: Enzymes; Models of active centres: acetylcholine; Active transport; Mode of action of insulin; Limitations of enzymes as models; Session 2: Receptors; Introduction: Receptors; Definition of receptors 327 $aIdentifying active centresEffect of denervation on receptors; Events at the cell membrane; Rate theory of drug action; Interaction at the Subcellular and Cellular Levels; Session 3: Subcellular Level; Introduction: Membranes; Subcellular particles; Phosphatidic acid cycle; Antihistamines and membrane permeability; Drug concentrations in vitro; Session 4: Cellular Level; Introduction: Cellular aspects; Reconstituting in vitro; In vitro and in vivo; Microsomal enzymes; Endoplasmic reticulum; Enzymes in young animals; Transaminase and GABA; Drug interactions; General considerations 410 0$aCiba Foundation symposium. 606 $aEnzymes$vCongresses 606 $aDrugs$xPhysiological effect$vCongresses 606 $aDrugs$xMetabolism$vCongresses 608 $aElectronic books. 615 0$aEnzymes 615 0$aDrugs$xPhysiological effect 615 0$aDrugs$xMetabolism 676 $a612.0151 701 $aMongar$b J. L$0867781 701 $aDe Reuck$b Anthony V. S$0290946 712 02$aBiological Council.$bCo-ordinating Committee for Symposia on Drug Action. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144848503321 996 $aCiba Foundation Symposium, jointly with Co-ordinating Committee for Symposia on Drug Action, on Enzymes and Drug Action$91936871 997 $aUNINA