LEADER 05296nam 2200625Ia 450 001 9910144738103321 005 20180718131728.0 010 $a1-280-85410-3 010 $a9786610854103 010 $a3-527-60779-X 010 $a3-527-60701-3 035 $a(CKB)1000000000377308 035 $a(EBL)481606 035 $a(OCoLC)70113548 035 $a(SSID)ssj0000191609 035 $a(PQKBManifestationID)11156543 035 $a(PQKBTitleCode)TC0000191609 035 $a(PQKBWorkID)10186628 035 $a(PQKB)11000500 035 $a(MiAaPQ)EBC481606 035 $a(EXLCZ)991000000000377308 100 $a20050902d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aLeukocyte trafficking$b[electronic resource] $emolecular mechanisms, therapeutic targets, and methods /$fedited by Alf Hamann and Britta Engelhardt 210 $aWeinheim $cWiley-VCH$dc2005 215 $a1 online resource (559 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31228-5 320 $aIncludes bibliographical references and index. 327 $aLeukocyte Trafficking; Contents; Preface; Acknowledgements; List of Authors; Color Plates; Part I Molecular Mechanisms; 1 The Multistep Model of Leukocyte Trafficking: A Personal Perspective from 15 Years Later; Acknowledgments; References; 2 Capture and Rolling: Selectins and Their Ligands; 2.1 Introduction; 2.2 Selectins; 2.2.1 L-Selectin; 2.2.2 P-Selectin; 2.2.3 E-Selectin; 2.3 P-Selectin Glycoprotein Ligand 1 and Other Ligands of Selectins; 2.4 Glycosyltransferases; References; 3 Chemokines and Their Receptors: Biochemical, Structural and Biological Properties; 3.1 Introduction 327 $a3.2 Chemokines3.3 Chemokine Receptors; 3.4 Role of Chemokines in Lymphocyte and Dendritic Cell Trafficking to and Within Primary and Secondary Lymphoid Organs; 3.4.1 Primary Lymphoid Organs; 3.4.1.1 Bone Marrow; 3.4.1.2 Thymus; 3.4.2 Secondary Lymphoid Organs; 3.4.2.1 Spleen; 3.4.2.2 Lymph Nodes; 3.4.2.3 Mucosa-Associated Lymphoid Tissue; Acknowledgments; References; 4 Mechanisms of Leukocyte Integrin Activation; 4.1 Introduction; 4.2 Modalities of Integrin Activation and the Role of Chemokines; 4.3 Signaling Mechanisms Controlling Rapid Integrin Activation 327 $a4.4 Chemokines, Integrins and Concurrency in Leukocyte Recruitment4.5 The Way Ahead; References; 5 Mechanisms of Leukocyte Transmigration: Role of Immunoglobulin Superfamily Molecules; 5.1 Introduction; 5.2 Leukocyte Migration Through Endothelial Cells; 5.3 Endothelial Cell Junctional Molecules; 5.4 Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Leukocyte Transmigration; 5.5 Intercellular Adhesion Molecules; 5.5.1 Structure, Ligands, and Expression Profile; 5.5.2 Role in Leukocyte Transmigration; 5.5.3 Signaling by ICAM-1 and ICAM-2; 5.6 Junctional Adhesion Molecules 327 $a5.6.1 Structure, Ligands, and Expression Profile5.6.2 Role in Leukocyte Transmigration; 5.6.3 Signaling by JAMs; 5.7 PECAM-1 (CD31); 5.7.1 Structure, Ligands, and Expression Profile; 5.7.2 Role in Leukocyte Transmigration; 5.7.3 Signaling by PECAM-1; 5.8 Role of Additional Molecules in Regulation of Leukocyte Transmigration; 5.8.1 T Cell Receptor; 5.8.2 CD99; 5.9 Summary and Future Directions; Acknowledgments; References; 6 The Endothelial Cell Basement Membrane and Its Role in Leukocyte Extravasation; 6.1 Introduction; 6.2 Extracellular Matrix of Blood Vessels; 6.2.1 Basement Membranes 327 $a6.2.2 Laminins6.3 Function of Endothelial Cell Basement Membranes; 6.3.1 Leukocyte Adhesion and Migration Studies; 6.3.2 Methods of Investigation of Leukocyte Migration on Extracellular Matrix Substrates; 6.3.3 Murine Inflammatory Models; 6.3.4 Role of Proteases; 6.4 Conclusion; Acknowledgment; References; Part II Trafficking in vivo; 7 Control of Homing Receptor Expression during Lymphocyte Differentiation, Activation, and Function; 7.1 Introduction; 7.2 Developing Lymphocytes Undergo Programmed Changes in Homing Receptor Expression 327 $a7.3 Control of Homing Receptor Expression During Lymphocyte Activation and Effector Cell Differentiation 330 $aWritten by known specialists in the field, this is a comprehensive and timely overview of a central and expanding topic. Simultaneously an introduction and a description of the latest concepts, findings and methods, the handbook provides basic knowledge on technical issues required for those intending to research in the field. It covers the functional role of involved molecules and the cellular mechanisms, and addresses selected examples for their possible application in therapy -- bridging the gap between trafficking mechanisms and novel therapeutic strategies. In addition, it includes select 606 $aLeucocytes 606 $aImmunology 608 $aElectronic books. 615 0$aLeucocytes. 615 0$aImmunology. 676 $a571.96 701 $aHamann$b Alf$0916487 701 $aEngelhardt$b Britta$0916488 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144738103321 996 $aLeukocyte trafficking$92054483 997 $aUNINA