LEADER 04639nam 2200745 a 450 001 9910144730503321 005 20170925043700.0 010 $a1-282-34607-5 010 $a9786612346071 010 $a0-470-51336-5 010 $a0-470-51337-3 035 $a(CKB)1000000000377239 035 $a(EBL)470665 035 $a(OCoLC)609849661 035 $a(SSID)ssj0000288904 035 $a(PQKBManifestationID)11241140 035 $a(PQKBTitleCode)TC0000288904 035 $a(PQKBWorkID)10381633 035 $a(PQKB)11511745 035 $a(MiAaPQ)EBC470665 035 $a(EXLCZ)991000000000377239 100 $a19860528d1986 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAntidepressants and receptor function$b[electronic resource] 210 $aChichester ;$aNew York $cWiley$d1986 215 $a1 online resource (306 p.) 225 1 $aCiba Foundation symposium ;$v123 300 $aEditors: Ruth Porter, Gregory Bock (organizers) and Sarah Clark. 300 $aProceedings of the Symposium on Depression, Antidepressants, and Receptor Sensitivity, held at the Ciba Foundation, London, 19-21 Nov. 1985. 300 $a"A Wiley-Interscience publication." 311 $a0-471-91089-9 320 $aIncludes bibliographies and indexes. 327 $aANTIDEPRESSANTS AND RECEPTOR FUNCTION; Contents; Participants; Introduction; Antidepressant-binding sites in brain and platelets; b-Adrenoceptor function in human adult skin fibroblasts: a study of manic- depressive illness; Genetic studies at the receptor level: investigations in human twins and experimental animals; Biochemical effects of antidepressant treat ment-studies of monoamine metabolites in cerebrospinal fluid and platelet [ 3H] imipramine binding; Platelet radioligand binding and neuroendocrine challenge tests in depression 327 $aHow antidepressants work: cautionary conclusions based on clinical and laboratory studies of the longer-term consequences of antidepressant drug treatmentNeuroendocrine and other studies of the mechanism of antidepressant action of desipramine; Adrenergic and serotonergic receptor responsiveness in depression; General discussion I; Effect of repeated administration of clenbuterol on the regulation of b-adrenoceptors in the central nervous system of the rat; Depression in an animal model: focus on the locus ceruleus 327 $aCauses of changes in brain noradrenaline systems and later effects on responses to social stressors in rhesus monkeys: the cascade hypothesisEffects of chronically ad ministered antidepressants and elect roconvulsive treatment on cerebral neurotransmitter receptors in rodents with 'model depression'; The effects of electroconvulsive therapy and antidepressant drugs on monoamine receptors in rodent brain-similarities and differences; General discussion II; Closing remarks; Index of contributors; Subject index 330 $aCiba Foundation Symposium 123 Antidepressants and Receptor Function Chairman: Dennis Murphy 1986 Depression is a common and often debilitating affective disorder. Attempts to develop effective antidepressants have a long history, but many questions remain about the mechanisms of action of such treatments and about the aetiology and pathophysiology of depression itself. Early observations centred attention on central monoamine systems, and animal studies suggested that changes in beta-adrenoceptor responsiveness were a common effect of antidepressant therapies. 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