LEADER 03925nam 2200673 a 450 001 9910144728803321 005 20170810191413.0 010 $a1-282-12237-1 010 $a9786612122378 010 $a0-470-51396-9 010 $a0-470-51397-7 035 $a(CKB)1000000000377329 035 $a(EBL)470475 035 $a(OCoLC)609849388 035 $a(SSID)ssj0000357198 035 $a(PQKBManifestationID)11278551 035 $a(PQKBTitleCode)TC0000357198 035 $a(PQKBWorkID)10352935 035 $a(PQKB)11272117 035 $a(MiAaPQ)EBC470475 035 $a(EXLCZ)991000000000377329 100 $a19900306d1990 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe biology of nicotine dependence$b[electronic resource] 210 $aChichester ;$aNew York $cWiley$d1990 215 $a1 online resource (276 p.) 225 1 $aCiba Foundation symposium ;$v152 300 $aProceedings of a symposium held at the Ciba Foundation, London, 7-9 November 1989. 300 $a"A Wiley-Interscience publication." 300 $aEditors: Greg Bock and Joan Marsh. 311 $a0-471-92688-4 320 $aIncludes bibliographical references and indexes. 327 $aTHE BIOLOGY OF NICOTINE DEPENDENCE; Contents; Introduction; Behavioural pharmacology of nicotine: implications for multiple brain nicotinic receptors; Structural and functional heterogeneity of nicotinic receptors; Mechanism of action of the nicotinic acetylcholine receptor; Modulation of nicotine receptors by chronic exposure to nicotinic agonists and antagonists; Presynaptic nicotinic receptors and the modulation of transmitter release; General discussion I : Inactivation of nicotinic cholinergic receptors; Location and function of nicotinic receptors in cultured cortical neurons 327 $aRegulation of endocrine function by the nicotinic cholinergic receptorEffects of nicotine on cerebral metabolism; General discussion II : Adaptive and cognitive aspects of the response to nicotine; Mesolimbic dopamine activation-the key to nicotine reinforcement?; Effect of nicotine on dynamic function of brain catecholamine neurons; Pharmacokinetic considerations in understanding nicotine dependence; Nicotine pharmacodynamics: some unresolved issues; Behavioural studies in humans: anxiety, stress and smoking; Final discussion : Withdrawal syndrome 327 $aPossible pharmacological therapies for nicotineUse of transdermal nicotine patches to help people give up smoking; Index of contributors; Subject index 330 $aNicotine is considered to be the main agent in the maintenance of the tobacco smoking habit and is largely responsible for the behavioral and physiological responses to the inhalation of tobacco smoke. This work presents advances made in the elucidation of the action of nicotine in the body--essential information for developing treatments to help people give up smoking. The book reviews the progress made in identifying nicotinic acetylcholine receptors in the brain, using the techniques of molecular biology to characterize receptors and investigate the functional differences between receptors 410 0$aCiba Foundation symposium ;$v152. 606 $aNicotine$xPhysiological effect$vCongresses 606 $aNicotinic receptors$vCongresses 606 $aTobacco use$xPhysiological aspects$vCongresses 608 $aElectronic books. 615 0$aNicotine$xPhysiological effect 615 0$aNicotinic receptors 615 0$aTobacco use$xPhysiological aspects 676 $a615.78 676 $a616.865 701 $aBock$b Gregory$0322650 701 $aMarsh$b Joan$091633 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144728803321 996 $aThe biology of nicotine dependence$91920522 997 $aUNINA