LEADER 05789nam 2200757Ia 450 001 9910144704303321 005 20230721004026.0 010 $a1-282-34322-X 010 $a9786612343223 010 $a0-470-75422-2 010 $a0-470-75421-4 035 $a(CKB)1000000000687468 035 $a(EBL)470456 035 $a(OCoLC)609849356 035 $a(SSID)ssj0000288467 035 $a(PQKBManifestationID)11222821 035 $a(PQKBTitleCode)TC0000288467 035 $a(PQKBWorkID)10373764 035 $a(PQKB)10446491 035 $a(MiAaPQ)EBC470456 035 $a(Au-PeEL)EBL470456 035 $a(CaPaEBR)ebr10300613 035 $a(CaONFJC)MIL234322 035 $a(EXLCZ)991000000000687468 100 $a20080318d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAirway smooth muscle in asthma and COPD$b[electronic resource] $ebiology and pharmacology /$fedited by Kian Fan Chung 210 $aHoboken, N.J. ;$aChichester $cWiley$d2008 215 $a1 online resource (332 p.) 300 $aDescription based upon print version of record. 311 $a0-470-06066-2 320 $aIncludes bibliographical references and index. 327 $aAirway Smooth Muscle; Contents; List of Contributors; 1 Biophysical basis of airway smooth muscle contraction and hyperresponsiveness in asthma; 1.1 Introduction; 1.2 Airway hyperresponsiveness; 1.3 Classical behaviour of airway smooth muscle and the balance of static forces; 1.4 Shortening velocity and other manifestations of muscle dynamics; 1.5 Biophysical characterization of airway smooth muscle: bronchospasm in culture?; 1.6 Mechanical plasticity: a nonclassical feature of airway smooth muscle; 1.7 Recent observations; 1.8 Future directions; References 327 $a2 Dynamics of cytoskeletal and contractile protein organization: an emerging paradigm for airway smooth muscle contraction2.1 Introduction; 2.2 Molecular structure and organization of contractile and cytoskeletal filaments in the airway smooth muscle cell; 2.3 Cytoskeletal dynamics and airway smooth muscle contraction; References; 3 Airway smooth muscle: role in airway constrictor hyperresponsiveness; 3.1 What is airway constrictor hyperresponsiveness (AHR)?; 3.2 Is AHR ever good?; 3.3 Potential mechanisms leading to airflow obstruction 327 $a3.4 Potential abnormalities of airway smooth muscle (ASM)3.5 If ASM is dysfunctional, how did it get that way?; 3.6 Summary; Acknowledgements; References; 4 Airway smooth muscle phenotypic and functional plasticity; 4.1 Introduction; 4.2 Historical perspective: smooth muscle phenotype plasticity; 4.3 Features of phenotype plasticity; 4.4 Mechanisms for phenotypic plasticity; 4.5 Functional plasticity of airway smooth muscle: role in asthma pathogenesis; 4.6 Concluding remarks; References; 5 Airway smooth muscle proliferation: insights into mechanisms regulating airway smooth muscle mass 327 $a5.1 Increases in airway smooth muscle (ASM) mass and the functional consequences5.2 Growth factors, inflammatory mediators and cytokines modulate ASM proliferation; References; 6 Airway smooth muscle bidirectional interactions with extracellular matrix; 6.1 Overview; 6.2 Introduction; 6.3 Airway extracellular matrix (ECM) in health and disease; 6.4 Integrins; 6.5 Airway smooth muscle (ASM) as a modulator of airway ECM; 6.6 Airway ECM as modulator of ASM function; 6.7 Impact of anti-asthma therapy on ASM-ECM interactions; 6.8 Conclusions; Acknowledgements; References 327 $a7 Airway smooth muscle interaction with mast cells7.1 Introduction; 7.2 Mast cell mediators alter smooth muscle function; 7.3 Smooth muscle cells induce mast cell chemotaxis; 7.4 Mast cells can adhere to airway smooth muscle; 7.5 Conclusion; Acknowledgements; References; 8 Airway smooth muscle synthesis of inflammatory mediators; 8.1 Introduction; 8.2 Lipid mediators; 8.3 Chemokines; 8.4 Growth and remodelling factors; 8.5 Conclusions; References; 9 Airway smooth muscle in experimental models; 9.1 Introduction; 9.2 Methods of assessment of airway smooth muscle (ASM) function 327 $a9.3 Potential mechanisms by which ASM properties may contribute to airway responsiveness 330 $aIn this book, leading researchers in medicine and molecular pharmacology explain the cellular mechanisms that control airway smooth muscle. The means by which these are disrupted in disease, and the pharmacologic strategies by which they may be modified are discussed and future therapeutic interventions are identified. Aimed at specialists in pulmonology, this volume provides the clinician with the most up to date information on one of the core physiological processes in airway disease, and offers insights into current and future approaches to management. Authori 606 $aRespiratory muscles$xPhysiology 606 $aSmooth muscle$xPhysiology 606 $aRespiratory muscles$xMolecular aspects 606 $aSmooth muscle$xMolecular aspects 606 $aRespiratory agents 606 $aRespiratory organs$xDiseases$xTreatment 606 $aRespiratory therapy 615 0$aRespiratory muscles$xPhysiology. 615 0$aSmooth muscle$xPhysiology. 615 0$aRespiratory muscles$xMolecular aspects. 615 0$aSmooth muscle$xMolecular aspects. 615 0$aRespiratory agents. 615 0$aRespiratory organs$xDiseases$xTreatment. 615 0$aRespiratory therapy. 676 $a616.2 701 $aChung$b K. Fan$f1951-$0879011 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144704303321 996 $aAirway smooth muscle in asthma and COPD$92229443 997 $aUNINA