LEADER 03864nam 2200661Ia 450 001 9910144700303321 005 20170816121010.0 010 $a1-282-34320-3 010 $a9786612343209 010 $a0-470-75403-6 010 $a0-470-75402-8 035 $a(CKB)1000000000687497 035 $a(EBL)470457 035 $a(OCoLC)243547536 035 $a(SSID)ssj0000290048 035 $a(PQKBManifestationID)11220389 035 $a(PQKBTitleCode)TC0000290048 035 $a(PQKBWorkID)10402479 035 $a(PQKB)10204308 035 $a(MiAaPQ)EBC470457 035 $a(EXLCZ)991000000000687497 100 $a20071023d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe biology of extracellular molecular chaperones$b[electronic resource] /$f[editors, Derek J. Chadwick and Jamie Goode] 210 $aChichester $cJohn Wiley$d2008 215 $a1 online resource (245 p.) 225 1 $aNovartis Foundation symposium ;$v291 300 $aPublished in association with the Novartis Foundation. 300 $a"Symposium on The biology of extracellular molecular chaperones, held at the Novartis Foundation, London, 5-7 June 2007" -- p. v. 311 $a0-470-72333-5 320 $aIncludes bibliographical references and index. 327 $aThe Biology of Extracellular Molecular Chaperones; Contents; Chair's introduction; 1962-2007: a cell stress odyssey; DISCUSSION; The chaperone function: meanings and myths; DISCUSSION; Systems biology of molecular chaperone networks; DISCUSSION; Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70 and Hsp10; DISCUSSION; Cell surface molecular chaperones as endogenous modulators of the innate immune response; DISCUSSION; Cell stress proteins in extracellular fluids: friend or foe?; DISCUSSION; HSP60 speaks to the immune system in many voices; DISCUSSION 327 $aCell stress proteins: novel immunotherapeuticsDISCUSSION; General discussion; Cell stress proteins as modulators of bacteria-host interactions; DISCUSSION; Chaperonin 60 and macrophage activation; DISCUSSION; Hsp70: a chaperokine; DISCUSSION; Extracellular functions of thioredoxin; DISCUSSION; HSP27: an anti-inflammatory and immunomodulatory stress protein acting to dampen immune function; DISCUSSION; BiP, an anti-inflammatory ER protein, is a potential new therapy for the treatment of rheumatoid arthritis; DISCUSSION; Final discussion; Contributor Index; Subject Index 330 $aThe heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses. Since the promulgation of the 'molecular chaperone' concept as a general cellular function to control the process of correct protein folding, a large number o 410 0$aNovartis Foundation symposium ;$v291. 606 $aExtracellular matrix proteins$vCongresses 606 $aMolecular chaperones$vCongresses 608 $aElectronic books. 610 1 $aExtracellular molecular chaperones 610 1 $aBiology 615 0$aExtracellular matrix proteins 615 0$aMolecular chaperones 676 $a572.6 676 $a612.01575 701 $aChadwick$b Derek$091632 701 $aGoode$b Jamie$0283336 712 02$aNovartis Foundation. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144700303321 996 $aThe biology of extracellular molecular chaperones$92186517 997 $aUNINA