LEADER 05187nam 22006254a 450 001 9910144640103321 005 20170815121700.0 010 $a1-280-27609-6 010 $a9786610276097 010 $a0-470-01126-2 010 $a0-470-01132-7 035 $a(CKB)1000000000226364 035 $a(EBL)239033 035 $a(OCoLC)304116727 035 $a(SSID)ssj0000180164 035 $a(PQKBManifestationID)11179429 035 $a(PQKBTitleCode)TC0000180164 035 $a(PQKBWorkID)10149465 035 $a(PQKB)11467678 035 $a(MiAaPQ)EBC239033 035 $a(EXLCZ)991000000000226364 100 $a20040720d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aInsulin resistance$b[electronic resource] $einsulin action and its disturbances in disease /$feditors, Sudhesh Kumar, Stephen O'Rahilly 210 $aChichester, West Sussex, England ;$aHoboken, N.J. $cJ. Wiley$dc2005 215 $a1 online resource (617 p.) 300 $aDescription based upon print version of record. 311 $a0-470-85008-6 320 $aIncludes bibliographical references and index. 327 $aInsulin Resistance; Contents; Preface; List of Contributors; 1 The Insulin Receptor and Downstream Signalling; 1.1 Introduction; 1.2 Insulin receptor structure and function; 1.3 Insulin receptor substrates; 1.4 Downstream signalling pathways; 1.5 The basis of insulin's signalling specificity; 1.6 Conclusion; References; 2 Insulin-mediated Regulation of Glucose Metabolism; 2.1 Introduction; 2.2 Insulin as a master regulator of whole body glucose disposal; 2.3 Insulin-mediated regulation of glucose metabolic pathways 327 $a2.4 Glucose uptake into skeletal muscle - the rate-limiting step in glucose metabolismAcknowledgements; References; 3 Insulin Action on Lipid Metabolism; 3.1 Introduction: does insulin affect lipid metabolism?; 3.2 Molecular mechanisms by which insulin regulates lipid metabolism; 3.3 Insulin and lipolysis; 3.4 Insulin, lipoprotein lipase and cellular fatty acid uptake; 3.5 Co-ordinated regulation of fatty acid synthesis and ketogenesis; 3.6 Insulin and cholesterol synthesis; 3.7 Insulin effects on lipoprotein metabolism; Acknowledgement; References 327 $a4 The Effect of Insulin on Protein Metabolism4.1 Introduction; 4.2 Molecular mechanisms of insulin's effect on protein turnover; 4.3 Measurement of protein metabolism (synthesis and breakdown or turnover) in human subjects; 4.4 Whole body and regional protein turnover; Acknowledgements; References; 5 Genetically Modified Mouse Models of Insulin Resistance; 5.1 Introduction; 5.2 Genetic modification as a tool to dissect the mechanisms leading to insulin resistance; 5.3 Candidate genes involved in the mechanisms of insulin resistance; 5.4 Insulin signalling network 327 $a5.5 Factors leading to insulin resistance5.6 Defining the function of the insulin cascade molecules through global knockouts; 5.7 Double heterozygous mice as models of polygenic forms of diabetes; 5.8 Defining tissue and/or organ relevance for the maintenance of insulin sensitivity; 5.9 Genetically modified mice to study modulators of insulin sensitivity; 5.10 Lipodystrophy versus obesity, the insulin resistance paradox; 5.11 Excess of nutrients as a cause of insulin resistance; 5.12 PPARs, key mediators of nutritional-regulated gene expression and insulin sensitivity; References 327 $a6 Insulin Resistance in Glucose Disposal and Production in Man with Specific Reference to Metabolic Syndrome and Type 2 Diabetes6.1 Introduction; 6.2 Measurement of insulin resistance; 6.3 Insulin-resistant states; 6.4 Conclusion and perspectives; References; 7 Central Regulation of Peripheral Glucose Metabolism; 7.1 Introduction; 7.2 Counter-regulation of hypoglycaemia - role of the CNS; 7.3 Brain regions involved in counter-regulation; 7.4 Glucosensing neurons; 7.5 Central control of peripheral organs involved in glucoregulation 327 $a7.6 Additional afferent signals to the CNS regulating peripheral glucose metabolism 330 $aDiabetes is now one of the major causes of morbidity worldwide. In many cases, the onset of diabetes is progressive, developing via a condition of insulin resistance. This book considers the development of this condition, its consequences and clinical and therapeutic aspects.The book reviews the normal biology of insulin action on glucose, lipids and proteins. It considers the pathological basis for insulin resistance in animal models and humans, and discusses the influence of heredity, dietary factors and exercise. Clinical consequences including dyslipidaemia, hypertension and polycy 606 $aInsulin resistance 608 $aElectronic books. 615 0$aInsulin resistance. 676 $a612.34 676 $a616.4/6207 676 $a616.46207 701 $aKumar$b Sudhesh$0855737 701 $aO'Rahilly$b S$g(Stephen)$0863273 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144640103321 996 $aInsulin resistance$91926987 997 $aUNINA LEADER 04842nam 2200661Ia 450 001 9910961711603321 005 20251117005401.0 010 $a0-470-91305-3 010 $a1-282-65682-1 010 $a9786612656828 010 $a0-470-91307-X 035 $a(CKB)2670000000032912 035 $a(EBL)555037 035 $a(OCoLC)651601963 035 $a(SSID)ssj0000404203 035 $a(PQKBManifestationID)11281301 035 $a(PQKBTitleCode)TC0000404203 035 $a(PQKBWorkID)10344762 035 $a(PQKB)10534148 035 $a(CaSebORM)9780470888452 035 $a(Au-PeEL)EBL555037 035 $a(CaPaEBR)ebr10411588 035 $a(CaONFJC)MIL265682 035 $a(MiAaPQ)EBC555037 035 $a(OCoLC)738406391 035 $a(OCoLC)ocn738406391 035 $a(EXLCZ)992670000000032912 100 $a20100419d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCompTIA Linux+ study guide $eexams LX0-101 and LX0-102 /$fRoderick W. Smith 205 $a1st ed. 210 $aIndianapolis, Ind. $cWiley Pub.$dc2010 215 $a1 online resource (651 p.) 300 $aIncludes index. 311 08$a0-470-88845-8 327 $aCompTIA Discount Coupon; CompTIA Linux+ Study Guide; Acknowledgments; About the Author; Contents ata a Glance; Contents; Table of Exercises; Introduction; The Exam Objectives; Assessment Test; Answers to Assessment Test; Part I: The CompTIA Linux+ LX0-101 Exam; Chapter 1: Exploring Linux Command-Line Tools; Understanding Command-Line Basics; Using Streams, Redirection, and Pipes; Processing Text Using Filters; Using Regular Expressions; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 2: Managing Software; Package Concepts; Using RPM; Using Debian Packages 327 $aConverting Between Package FormatsPackage Dependencies and Conflicts; Managing Shared Libraries; Managing Processes; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 3: Configuring Hardware; Configuring the BIOS and Core Hardware; Configuring Expansion Cards; Configuring USB Devices; Configuring Hard Disks; Designing a Hard Disk Layout; Creating Partitions and Filesystems; Maintaining Filesystem Health; Mounting and Unmounting Filesystems; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 4: Managing Files; Managing Files 327 $aManaging File OwnershipControlling Access to Files; Managing Disk Quotas; Locating Files; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 5: Booting Linux and Editing Files; Installing Boot Loaders; Understanding the Boot Process; Dealing with Runlevels and the Initialization Process; Editing Files with Vi; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Part II: The CompTIA Linux+ LX0-102 Exam; Chapter 6: Configuring the X Window System, Localization, and Printing; Configuring Basic X Features; Configuring X Fonts; Managing GUI Logins 327 $aUsing X for Remote AccessX Accessibility; Configuring Localization and Internationalization; Configuring Printing; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 7: Administering the System; Managing Users and Groups; Tuning User and System Environments; Using System Log Files; Maintaining the System Time; Running Jobs in the Future; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 8: Configuring Basic Networking; Understanding TCP/IP Networking; Understanding Network Addressing; Configuring Linux for a Local Network 327 $aSystem Requirements 330 $aNew edition prepares candidates for exams LX0-101 and LX0-102-and Linux+ certification! The two leading Linux certification bodies, CompTIA and Linux Professional Institute (LPI), have joined forces to release two new Linux+ exams, LX0-101 and LX0-102. This new Sybex study guide breaks down everything you need to prepare for the exams. Covering all exam objectives, the book explains Linux command-line tools, managing software, configuring hardware, managing files and filesystems, and much more. The companion CD features a leading-edge test engine and a host of other study tools, givi 606 $aElectronic data processing personnel$xCertification 606 $aOperating systems (Computers)$xExaminations$vStudy guides 615 0$aElectronic data processing personnel$xCertification. 615 0$aOperating systems (Computers)$xExaminations 676 $a005.4/32 700 $aSmith$b Roderick W$01603883 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910961711603321 996 $aCompTIA Linux+ study guide$94456471 997 $aUNINA