LEADER 03905nam 2200625Ia 450 001 9910144563403321 005 20180702172945.0 010 $a1-281-32009-9 010 $a9786611320096 010 $a0-470-99403-7 010 $a0-470-99402-9 035 $a(CKB)1000000000377106 035 $a(EBL)351038 035 $a(OCoLC)437214038 035 $a(SSID)ssj0000131087 035 $a(PQKBManifestationID)11129159 035 $a(PQKBTitleCode)TC0000131087 035 $a(PQKBWorkID)10015407 035 $a(PQKB)10711854 035 $a(MiAaPQ)EBC351038 035 $a(EXLCZ)991000000000377106 100 $a20070626d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCortical development$b[electronic resource] $egenes and genetic abnormalities /$f[editors: Gregory Bock and Jamie Goode] 210 $aChichester, UK ;$aHoboken, NJ $cWiley$d2007 215 $a1 online resource (303 p.) 225 1 $aNovartis Foundation symposium ;$v288 300 $a"Chair: John Parnavelas." 311 $a0-470-06092-1 320 $aIncludes bibliographical references and indexes. 327 $aCORTICAL DEVELOPMENT: GENES AND GENETIC ABNORMALITIES; Contents; Chair's introduction; Molecular development of corticospinal motor neuron circuitry; DISCUSSION; Perspectives on the developmental origins of cortical interneuron diversity; DISCUSSION; Genetic determinants of neuronal migration in the cerebral cortex; DISCUSSION; Neural stem and progenitor cells in cortical development; DISCUSSION; Genes that control the size of the cerebral cortex; DISCUSSION; General Discussion I; Control of cortical neuron layering: lessons from mouse chimeras; DISCUSSION 327 $aIntracortical multidirectional migration of cortical interneuronsDISCUSSION; The atypical cadherin Celsr3 regulates the development of the axonal blueprint; DISCUSSION; Regulation of laminar and area patterning of mammalian neocortex and behavioural implications; DISCUSSION; Genetic regulation of prefrontal cortex development and function; DISCUSSION; Self-organization and pattern formation in primate cortical networks; DISCUSSION; Molecular mechanisms of thalamocortical axon targeting; DISCUSSION; Genes involved in the formation of the earliest cortical circuits; DISCUSSION 327 $aEmx and Nfi genes regulate cortical development and axon guidance in the telencephalonDISCUSSION; Schizophrenia susceptibility genes and their neurodevelopmental implications: focus on neuregulin 1; DISCUSSION; Focal brain malformations: a spectrum of disorders along the mTOR cascade; DISCUSSION; Final Discussion; Contributor Index; Subject Index 330 $aTo understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime. This book features a timely and insightful discussion between developmental neurobiologists and clinicians who deal with disorders of the nervous system. Chapters in this book deal specifically with cell fate determination, cell migration and disorders of cell migration; current concepts and new ideas about cortical arealisation, and disorders which can arise from incorrect arealisation; genes implicated in the develo 410 0$aNovartis Foundation symposium ;$v288. 606 $aBrain$xGrowth 606 $aDevelopmental neurophysiology 608 $aElectronic books. 615 0$aBrain$xGrowth. 615 0$aDevelopmental neurophysiology. 676 $a612.825 701 $aBock$b Gregory$0322650 701 $aGoode$b Jamie$0283336 701 $aParnavelas$b J. G$g(John G.)$0862799 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144563403321 996 $aCortical development$91926067 997 $aUNINA