LEADER 05043nam 2200637Ia 450 001 9910144562603321 005 20201005144456.0 010 $a1-280-72336-X 010 $a9786610723362 010 $a3-527-60818-4 010 $a3-527-60790-0 035 $a(CKB)1000000000377114 035 $a(EBL)481528 035 $a(OCoLC)609855333 035 $a(SSID)ssj0000299577 035 $a(PQKBManifestationID)11196163 035 $a(PQKBTitleCode)TC0000299577 035 $a(PQKBWorkID)10242549 035 $a(PQKB)10091944 035 $a(MiAaPQ)EBC481528 035 $a(EXLCZ)991000000000377114 100 $a20050317d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIndustrial biotransformations$b[electronic resource] /$fedited by Andreas Liese, Karsten Seelbach, Christian Wandrey 205 $a2nd completely rev and extened ed. 210 $aWeinheim $cWiley-VCH ;$aChichester $cJohn Wiley [distributor]$d2006 215 $a1 online resource (572 p.) 300 $aPrevious ed.: 2000. 311 $a3-527-31001-0 320 $aIncludes bibliographical references and index. 327 $aIndustrial Biotransformations; Contents; Preface to the first edition; Preface to the second edition; List of Contributors; 1 History of Industrial Biotransformations - Dreams and Realities; 1.1 From the "Flower of Vinegar" to Recombinant E. Coli - The History of Microbial Biotransformations; 1.2 From Gastric Juice to SweetzymeT - The History of Enzymatic Biotransformations; 1.3 From Wine Bottle to a State-of-the-Art Facility - The History of Biochemical Engineering; 1.4 Advantages of Biotransformations Over Classical Chemistry Enzymes are proteins, things of beauty and a joy forever [40] 327 $a2 The Enzyme Classification2.1 Enzyme Nomenclature; 2.2 Enzyme Classes; 2.2.1 EC 1 Oxidoreductases; 2.2.2 EC 2 Transferases; 2.2.3 EC 3 Hydrolases; 2.2.4 EC 4 Lyases; 2.2.5 EC 5 Isomerases; 2.2.6 EC 6 Ligases; 3 Retrosynthetic Biocatalysis; 3.1 Alkanes; 3.2 Alkenes; 3.3 Amines; 3.4 Alcohols; 3.5 Aldehydes; 3.6 Ketones; 3.7 Epoxides; 3.8 Diols; 3.9 Carboxylic Acids; 3.10 Esters; 3.11 Amides; 3.12 Imines; 3.13 Amino Acids; 3.14 Hydroxy Acids; 3.15 ?-Hydroxy Ketones; 3.16 ?-Hydroxy Aldehydes, Ketones or Carboxylic Acids; 3.17 Cyanohydrins, Hemithioacetals and Hemiaminals 327 $a3.18 Sulfoxides and Sulfones3.19 Halides; 3.20 Aromatics (Ring Functionalization); 3.21 Cyclic Compounds; 3.22 Carbohydrates; 3.23 Peroxides; 3.24 Isomers; 3.25 Examples of Retrosynthetic Biotransformations; 3.25.1 Example 1; 3.25.2 Example 2; 4 Optimization of Industrial Enzymes by Molecular Engineering; 4.1 Introduction; 4.2 Learning from Nature; 4.3 Enzyme Production Using Bacterial Expression Hosts; 4.4 Improvements to Enzymes by Molecular Engineering Techniques; 4.4.1 Rational Enzyme Design; 4.4.2 Directed Evolution; 4.4.3 Random Mutagenesis Methods 327 $a4.5 Identification of Improved Enzyme Variants4.6 Conclusions and Future Prospects; 5 Basics of Bioreaction Engineering; 5.1 Definitions; 5.1.1 Process Definitions; 5.1.2 Definitions of Unit Operations; 5.2 Biocatalyst Kinetics; 5.2.1 Types of Biocatalysts; 5.2.2 Enzyme Structure; 5.2.3 Kinetics; 5.3 Basic Reactor Types and their Modes of Operation; 5.3.1 Mass and Energy Balances; 5.4 Biocatalyst Recycling and Recovery; 5.4.1 Entrapment; 5.4.2 Cross-linking; 5.4.3 Covalent Binding; 5.4.4 Membrane Filtration; 5.5 Reaction Parameters; 5.6 Scale-up of Bioreactors 327 $a5.7 Recent Developments and Trends6 Processes; Oxireductases EC 1; Transferases EC 2; Hydrolases EC 3; Lyases EC 4; Isomerases EC 5; 7 Quantitative Analysis of Industrial Biotransformations; Index; Index of enzyme name; Index of strain; Index of company; Index of starting material; Index of product 330 $aThe completely revised second edition of this user-friendly and application-oriented overview of one-step biotransformations of industrial importance. Based on extensive literature and patent research, this book is unique in arranging each process in a systematic way to allow for easy comparison. All the chapters have been rewritten, with all the processes updated and more than 30 new processes added. Each set of data is accompanied by key literature citations, supported by flow sheets where available, reduced to their significant elements. In addition, an extensive index classified by sub 606 $aBiotransformation (Metabolism) 606 $aBiochemical engineering 608 $aElectronic books. 615 0$aBiotransformation (Metabolism) 615 0$aBiochemical engineering. 676 $a660.63 701 $aLiese$b A$g(Andreas)$0879057 701 $aSeelbach$b K$g(Karsten)$0724699 701 $aWandrey$b Christian$f1943-$0724698 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144562603321 996 $aIndustrial biotransformations$92203941 997 $aUNINA