LEADER 05147nam 2200613Ia 450 001 9910144557803321 005 20170816123759.0 010 $a1-280-51969-X 010 $a9786610519699 010 $a3-527-60380-8 010 $a3-527-60434-0 035 $a(CKB)1000000000377162 035 $a(EBL)482201 035 $a(OCoLC)68571579 035 $a(SSID)ssj0000119363 035 $a(PQKBManifestationID)11132325 035 $a(PQKBTitleCode)TC0000119363 035 $a(PQKBWorkID)10072798 035 $a(PQKB)10527648 035 $a(MiAaPQ)EBC482201 035 $a(PPN)250325381 035 $a(EXLCZ)991000000000377162 100 $a20041011d2004 fy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCentrosomes in development and disease$b[electronic resource] /$fedited by Erich A. Nigg 210 $aWeinheim ;$a[Great Britain] $cWiley-VCH$dc2004 215 $a1 online resource (475 p.) 300 $aDescription based upon print version of record. 311 $a3-527-30980-2 320 $aIncludes bibliographical references and index. 327 $aCentrosomes in Development and Disease; Contents; Preface; List of Contributors; Color Plates; Part I Microtubule Organization and Dynamics; 1 Early Studies on Centrioles and Centrosomes; 1.1 Introduction; 1.2 Pioneering Studies; 1.3 Self-replication versus De Novo Formation; 1.4 Centrioles and Basal Bodies; 1.5 Blepharoplasts; 1.6 The Search for DNA; 1.7 On to Self-assembly; References; 2 The Tubulin Superfamily; 2.1 History; 2.2 Family Relations; 2.3 Localization and Function; 2.4 ?-Tubulin; 2.5 ?-Tubulin; 2.6 ?-Tubulin; 2.7 Other Members of the Fold; References; 3 Microtubule Nucleation 327 $a3.1 Introduction3.1.1 The Nucleation of Microtubules can occur Spontaneously In Vitro, but Requires ?-Tubulin In Vivo; 3.1.2 Models for the Mechanism of ?-TuRC/Tub4 Complex-mediated Microtubule Nucleation; 3.2 Kinetic Models of the Mechanism of Microtubule Nucleation; 3.3 The Involvement of Non-?-TuRC Proteins in Microtubule Nucleation; 3.4 Future Directions; Acknowledgments; References; 4 The Budding Yeast Spindle Pole Body: A Centrosome Analog; 4.1 Introduction; 4.2 Molecular Composition of the Spindle Pole Body; 4.2.1 The Central Plaque; 4.2.2 The Inner Plaque; 4.2.3 The Outer Plaque 327 $a4.2.4 Nuclear Membrane Factors4.2.5 The Halfbridge; 4.2.6 Structure Summary; 4.3 Microtubule Nucleation; 4.4 Assembly/Duplication of SPBs and Centrosomes; 4.4.1 Electron Microscopic Description of Duplication; 4.4.2 Cell Cycle Regulation of Duplication; 4.4.3 Genetic Analysis of Duplication; 4.5 Signaling Platform; 4.6 Developmental Alteration of SPB Function; 4.7 Parting Thoughts; Acknowledgments; References; 5 Dissection of Basal Body and Centriole Function in the Unicellular Green Alga Chlamydomonas reinhardtii; 5.1 Introduction 327 $a5.2 Why Study a Green Alga to Learn about Centrioles and Basal Bodies?5.3 Structure of the Basal Body and Centriole in Chlamydomonas; 5.4 Additional Fibers that Connect Basal Bodies and Centrioles; 5.4.1 Contractile Fibers; 5.4.2 Rootlet Microtubules; 5.4.3 Non-contractile Fibers; 5.5 Overview of the Cell Cycle of Chlamydomonas; 5.6 Duplication of Basal Bodies in Chlamydomonas; 5.7 Role of Tubulin Isoforms in Basal Body Duplication; 5.8 Timing of Basal Body/Centriole Duplication in Chlamydomonas; 5.9 Function of Basal Bodies and Centrioles in Chlamydomonas 327 $a5.10 What Makes a Basal Body Different from a Centriole?5.10.1 Transition Zone and Docking; 5.10.2 Transition Zone and Autonomy; 5.10.3 Maturation of Basal Bodies; 5.11 Conclusion; Acknowledgments; References; 6 The Centrosome in Evolution; 6.1 Introduction; 6.2 The Centriole/Basal Body Structure is a Derived Characteristic of Eukaryotes; 6.3 The Basal Body/Axoneme is the Ancestral Structure; 6.4 Functions Associated with the Flagellar Apparatus; 6.4.1 Cell Locomotion; 6.4.2 Sensory Reception; 6.4.3 Cell Division 327 $a6.5 The Conservative Mode of Duplication of the Basal Body/Centriole/SPB: An Essential Clue for Cell Morphogenesis 330 $aDiscovered over a century ago, the centrosome is the major microtubule organizing center of the animal cell. It is a tiny organelle of surprising structural complexity. Over the last few years our understanding of the structure and composition of centrosomes has greatly advanced, and the demonstration of frequent centrosome anomalies in most common human tumors has sparked additional interest in the role of this organelle in a broader scientific community.The centrosome controls the number and distribution of microtubules - a major element of the cell cytoskeleton - and hence influence 606 $aCentrosomes 606 $aCytology 615 0$aCentrosomes. 615 0$aCytology. 676 $a571.65 701 $aNigg$b Erich A$0916475 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144557803321 996 $aCentrosomes in development and disease$92054468 997 $aUNINA LEADER 01652oam 2200433 a 450 001 9910700912503321 005 20110922134859.0 035 $a(CKB)5470000002413906 035 $a(OCoLC)753704046 035 $a(EXLCZ)995470000002413906 100 $a20110920d2011 ua 0 101 0 $aeng 135 $aurmn||||a|||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aLiving within our means and investing in the future$b[electronic resource] $ethe President's plan for economic growth and deficit reduction 210 1$aWashington, D.C. :$cExecutive Office of the President, Office of Management and Budget,$d[2011] 215 $a1 online resource (v, 67 pages) $ccharts 300 $aTitle from PDF title page (viewed on Sept. 20, 2011). 300 $a"September 2011"--P. 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