LEADER 05421nam 22007334a 450 001 9910144557103321 005 20200520144314.0 010 $a9786610854073 010 $a9781280854071 010 $a1280854073 010 $a9783527607020 010 $a3527607021 010 $a9783527606986 010 $a352760698X 035 $a(CKB)1000000000377169 035 $a(EBL)481850 035 $a(SSID)ssj0000104173 035 $a(PQKBManifestationID)11122683 035 $a(PQKBTitleCode)TC0000104173 035 $a(PQKBWorkID)10079634 035 $a(PQKB)11073057 035 $a(MiAaPQ)EBC481850 035 $a(OCoLC)85820785 035 $a(Perlego)2750740 035 $a(EXLCZ)991000000000377169 100 $a20080226d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAntigen presenting cells $efrom mechanisms to drug development /$fedited by Harald Kropshofer and Anne B. Vogt 210 $aWeinheim $cWiley-VCH$dc2005 215 $a1 online resource (653 p.) 300 $aDescription based upon print version of record. 311 08$a9783527311088 311 08$a3527311084 320 $aIncludes bibliographical references and index. 327 $aAntigen Presenting Cells; Contents; Preface; Acknowledgments; List of Contributors; List of Abbreviations; Color Plates; Part I Antigen Presentation in the Immune System; 1 Some Old and Some New Findings on Antigen Processing and Presentation; 1.1 Introduction; 1.2 HEL Processing; 1.3 Selection of Peptide Segments of HEL; 1.4 HEL: Conformational Isomers; 1.4.1 Biology of Type B T Cells; 1.5 Negative Selection and Peripheral Activation to HEL Peptides; 1.6 Response to HEL Immunization in the Draining Lymph Node; Part II Molecular Mechanisms of Antigen Processing 327 $a2 Antigen Entry Routes - Where Foreign Invaders Meet Antigen Presenting Cells2.1 Introduction; 2.2 Antigen Entry via the Gastrointestinal Tract; 2.2.1 Peyer's Patches; 2.2.2 Mesenteric Lymph Node; 2.2.3 Dendritic Cells of the Lamina Propria; 2.2.4 Pathogens Target Intestinal Antigen Presenting Cells; 2.3 Antigen Entry via the Skin; 2.4 Systemic Dissemination of Antigens/Infectious Microorganisms; 2.5 Antigen Presenting Cells in the Liver; 2.5.1 Dendritic Cells; 2.5.2 Kupffer Cells; 2.5.3 Liver Sinusoidal Endothelial Cells; 2.6 Conclusion 327 $a3 Antigen Processing in the Context of MHC Class I Molecules3.1 Tracing the Needle in the Haystack: The Efficiency of Antigen Processing and Presentation by MHC Class I Molecules; 3.2 The "Classical" Route: Loading of MHC Class I Molecules With Peptides Generated in the Cytoplasm; 3.2.1 Cytosolic Peptide Processing by Proteasomes and other Proteases; 3.2.1.1 Structure and Function of the Proteasomal Core and Interferon-induced Subunits; 3.2.1.2 Targeting Proteins for ATP-dependent Degradation by 26S Proteasomes; 3.2.1.3 Cleavage Properties of (Immuno)Proteasomes 327 $a3.2.1.4 Peptide Processing by Nonproteasomal Cytosolic Peptidases3.3 Crossing the Border - Peptide Translocation into the ER by TAP; 3.3.1 Structure and Function of TAP; 3.3.2 Substrate Specificity of TAP; 3.3.3 TAP-independent Peptide Entry into the ER; 3.4 Fitting in the Best: TAP-associated Peptide Loading Complex Optimizes MHC-I Peptide Binding; 3.4.1 Structure of MHC-I Molecules; 3.4.2 Early Steps in the Maturation of MHC-I Molecules; 3.4.3 Structure and Molecular Interactions of Tapasin; 3.4.4 Optimization of Peptide Loading in the TAP-associated Loading Complex 327 $a3.5 On the Way Out: MHC-I Antigen Processing along the Secretory Route3.6 Closing the Circle - Cross-presentation of Endocytosed Antigens by MHC-I Molecules; 3.6.1 Phagosome-to-cytosol Pathway of MHC-I Peptide Loading; 3.6.2 Endolysosomal Pathway of MHC-I Peptide Loading; 4 Antigen Processing for MHC Class II; 4.1 Introduction; 4.2 Types of Antigen Presenting Cells; 4.2.1 Macrophages, B Lymphocytes and DCs; 4.2.2 Tissue-resident APCs; 4.2.3 Maturation State of APCs; 4.2.3.1 Immature APCs; 4.2.3.2 Mature APCs; 4.3 Antigen Uptake by APCs; 4.3.1 Macropinocytosis; 4.3.2 Phagocytosis 327 $a4.3.3 Receptors for Endocytosis 330 $aThis novel, multidisciplinary handbook highlights recent evidence that antigen presenting cells (APCs) are not only key players in the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune response, but also critical regulators and integrators in the interplay between our innate and adaptive immune system.Structured in a clear way to allow access to a very broad readership, the book is written from the viewpoint of a biochemist, immunologist, and scientist with experience in drug development. It covers all cell types involved in antigen presentation, providi 606 $aAntigen presenting cells 606 $aAntigenen$2gtt 606 $aCelbiologie$2gtt 606 $aFarmacologie$2gtt 615 0$aAntigen presenting cells. 615 17$aAntigenen. 615 17$aCelbiologie. 615 17$aFarmacologie. 676 $a571.9/677 686 $a42.15$2bcl 701 $aKropshofer$b Harald$0935713 701 $aVogt$b Anne B$0935714 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144557103321 996 $aAntigen presenting cells$92107750 997 $aUNINA