LEADER 05200nam 2200613Ia 450 001 9910144556903321 005 20170925002546.0 010 $a1-280-85434-0 010 $a9786610854349 010 $a3-527-60802-8 010 $a3-527-60737-4 035 $a(CKB)1000000000377171 035 $a(EBL)482001 035 $a(OCoLC)70161547 035 $a(SSID)ssj0000176907 035 $a(PQKBManifestationID)11171533 035 $a(PQKBTitleCode)TC0000176907 035 $a(PQKBWorkID)10210754 035 $a(PQKB)10777158 035 $a(MiAaPQ)EBC482001 035 $a(EXLCZ)991000000000377171 100 $a20050106d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aImmunodominance$b[electronic resource] $ethe choice of the immune system /$fedited by Jeffrey A. Frelinger 210 $aWeinheim $cWiley-VCH ;$aChichester $cJohn Wiley [distributor]$d2006 215 $a1 online resource (316 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31274-9 320 $aIncludes bibliographical references and index. 327 $aImmunodominance; Contents; Preface; List of Contributors; Color Plates; I Mechanics of Antigen Processing; 1 Class I MHC Antigen Processing; 1.1 Introduction; 1.2 Properties of MHC; 1.2.1 Structure of MHC; 1.2.2 Polymorphic Residues Generate Specificity Pockets; 1.3 Properties of Peptides; 1.3.1 Peptides That Bind Are Not Random Sequences; 1.3.2 Peptide-binding Motifs; 1.3.3 Peptide Length Is Limited in Class I MHC Peptides; 1.3.4 Binding Affinity; 1.3.5 Molecular Recognition; 1.3.6 Epitope Prediction; 1.4 Cytosolic Processing; 1.4.1 The Proteasome; 1.4.2 The Immunoproteasome 327 $a1.4.3 Opening the Immunoproteasome1.4.4 Peptide Trimming; 1.4.5 Association of the Proteasome with the Endoplasmic Reticulum; 1.5 Peptide Transport; 1.5.1 Transport via TAP; 1.5.2 TAP Selectivity; 1.5.3 TAP-independent Peptide Transport; 1.5.3.1 Endogenous Peptides; 1.5.3.2 Exogenous Peptides; 1.6 Class I MHC Maturation and Peptide Loading; 1.6.1 ER Chaperones: Calnexin, Calreticulin, ERp57, and Tapasin; 1.6.1.1 Calnexin; 1.6.1.2 Tapasin; 1.6.1.3 ERp57; 1.6.1.4 Calreticulin; 1.6.2 Peptide Loading; 1.7 Immunodominance and Class I MHC Peptide Processing 327 $a2 The Mechanics of Class II Processing: Establishment of a Peptide Class II Hierarchy2.1 General Overview; 2.1.1 Immunodominance and Crypticity; 2.1.2 The Impact of T-Cell Repertoire in the Experimental Analysis of Immunodominance; 2.1.3 Different Antigen-presenting Cells Have Different Functions; 2.1.4 The Phases of Antigen Processing; 2.2 Phase I: MHC Class II Biosynthesis and Delivery to Peptide-loading Compartments; 2.2.1 Invariant Chain Isoforms; 2.2.2 Effects of Cell Signaling on MHC Class II Transport; 2.3 Phase II: Antigen Internalization and Processing 327 $a2.3.1 BCR-mediated Antigen Internalization2.3.2 Dendritic Cells and Macrophages; 2.4 Phase III: Formation and Expression of Antigenic Peptide by MHC Class II Molecules; 2.4.1 Proteolytic Antigen Processing; 2.4.2 Class II Peptide Loading; 2.4.2.1 DM; 2.4.2.2 DO; 2.4.2.3 DO-, DM-, and BCR-Mediated Antigen Processing; 2.4.2.4 The Distribution of MHC Class II and Other Proteins Within MIIC; 2.4.3 Cell-surface Delivery of Peptide-Class II Complexes; 2.4.3.1 Exosomes; 2.4.3.2 Signaling Properties of Peptide-Class II Complexes; 2.5 Conclusions; Acknowledgments 327 $a3 The Phenomenon of Immunodomination: Speculations on the Nature of Immunodominance3.1 Introduction; 3.2 MHC Binding, Cellular Processing, and T-Cell Repertoire are Major Determinants of Immunodominance; 3.3 Previous Systematic Analysis of Immunodominance by Our Group; 3.4 Cellular and Molecular Events in Immunodomination; 3.5 Speculations on the Mechanism of Immunodomination; 3.5.1 Involvement of APCs; 3.5.2 Possible Involvement of the Immune Synapse in Immunodomination; 3.5.3 The Potential Role of MTOC in Immunodomination; 3.6 Significance of Studying Immunodominance for Vaccine Development 327 $a3.7 Conclusions 330 $aThis very first handbook on the topic summarizes the current concepts and brings together in one volume the critical arguments concerning the mechanisms relevant to immunodominance. In invited chapters written by the leaders in the field, the mechanisms whereby the immune system chooses the parts of a recognized pathogen in order to start the immune response are explained and the variety of biologic processes are identified that contribute to that choice. From the contents:* Mechanics of antigen processing* Proteosome specificity and immuno-proteosomes* Effect of the T cell re 606 $aImmune response$xRegulation 606 $aAntigenic determinants$xResearch 608 $aElectronic books. 615 0$aImmune response$xRegulation. 615 0$aAntigenic determinants$xResearch. 676 $a616.079 701 $aFrelinger$b Jeffrey A$0958190 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144556903321 996 $aImmunodominance$92170869 997 $aUNINA