LEADER 05213nam 2200613Ia 450 001 9910144556803321 005 20170924205428.0 010 $a1-280-85433-2 010 $a9786610854332 010 $a3-527-60803-6 010 $a3-527-60736-6 035 $a(CKB)1000000000377172 035 $a(EBL)482336 035 $a(OCoLC)70159059 035 $a(SSID)ssj0000261262 035 $a(PQKBManifestationID)11206105 035 $a(PQKBTitleCode)TC0000261262 035 $a(PQKBWorkID)10255485 035 $a(PQKB)10374377 035 $a(MiAaPQ)EBC482336 035 $a(EXLCZ)991000000000377172 100 $a20050106d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aTranscription factors in the nervous system$b[electronic resource] $edevelopment, brain function and diseases /$fedited by Gerald Thiel 210 $aWeinheim $cWiley-VCH$dc2006 215 $a1 online resource (507 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31285-4 320 $aIncludes bibliographical references and index. 327 $aTranscription Factors in the Nervous System; Contents; Preface; List of Contributors; Color Plates; Part I Transcription Factors in Neural Development; 1 Roles of Hes bHLH Factors in Neural Development; 1.1 Introduction; 1.2 Structure and Transcriptional Activities of Hes Factors; 1.3 Regulation of Hes Gene Expression; 1.4 Expression of Hes Genes in the Developing Nervous System; 1.5 Maintenance of Neural Stem Cells by Hes Genes; 1.6 Promotion of Gliogenesis by Hes Genes; 1.7 Maintenance of the Isthmic Organizer by Hes Genes; 1.8 Perspective; Acknowledgments; Abbreviations 327 $a2 The Role of Pax6 in the Nervous System during Development and in Adulthood: Master Control Regulator or Modular Function?Abstract; 2.1 Introduction; 2.2 Molecular Features of Pax6; 2.2.1 The Paired Domain; 2.2.2 The Paired-Type Homeodomain; 2.2.3 Different Pax6 Isoforms; 2.2.4 Protein-Protein Interactions; 2.2.5 Post-Translational Modifications of Pax6; 2.3 Function of Pax6 in Development; 2.3.1 Function of Pax6 in the Developing Eye; 2.3.2 Function of Pax6 in the Developing Brain; 2.3.2.1 Telencephalon; 2.3.2.2 Diencephalon; 2.3.2.3 Cerebellum; 2.3.2.4 Spinal Cord 327 $a2.4 Function of Pax6 in the Adult Brain2.5 Mechanisms of Pax6 Function; 2.6 Conclusions and Outlook; Abbreviations; 3 Phox2a and Phox2b: Essential Transcription Factors for Neuron Specification and Differentiation; Abstract; 3.1 Introduction; 3.2 Molecular Characteristics of Phox2 Genes and Proteins; 3.2.1 Sequence and Gene Structure Conservation in the Animal Kingdom; 3.2.2 Transcriptional Activation by Phox2 Proteins; 3.3 Physiological Relevance of Phox2 Transcription Factors; 3.3.1 Expression Pattern; 3.3.2 Effects of Phox2 Gene Mutations 327 $a3.3.2.1 Autonomic Neural Crest Derivatives and Visceral Sensory Ganglia3.3.2.2 Central Noradrenergic Neurons; 3.3.2.3 Autonomic Centers in the Hindbrain; 3.3.3 Human Mutations; 3.4 Molecular Mechanism of Action in Different Lineages; 3.4.1 Sympathetic Neurons; 3.4.2 Parasympathetic Neurons; 3.4.3 Enteric Neurons; 3.4.4 Visceral Sensory Neurons of the Geniculate, Petrosal and Nodose Ganglia; 3.4.5 Central Noradrenergic Neurons; 3.4.6 Autonomic Centers in the Hindbrain; 3.4.6.1 Afferent Visceral Centers; 3.4.6.2 Efferent Visceral Centers; 3.4.7 Oculomotor (nIII) and Trochlear (nIV) Centers 327 $a3.5 Conclusions and Outlook3.5.1 Distinct or Identical Functions for Phox2a and Phox2b?; 3.5.2 Master Control Genes for Noradrenergic Differentiation; 3.5.3 Master Control Genes for Autonomic Reflex Circuit Generation; Acknowledgments; Abbreviations; 4 Functions of LIM-Homeodomain Proteins in the Development of the Nervous System; Abstract; 4.1 Introduction; 4.2 Common Structural Features and Classification of LIM-HD Proteins; 4.3 LIM-HD Proteins and the Development of Invertebrate Nervous Systems; 4.3.1 C. elegans; 4.3.2 Drosophila 327 $a4.4 Functions of LIM-HD Proteins in the Development of Vertebrate Nervous Systems 330 $aThis first book to cover neural development, neuronal survival and function on the genetic level outlines promising approaches for novel therapeutic strategies in fighting neurodegenerative disorders, such as Alzheimer's disease. Focusing on transcription factors, the text is clearly divided into three sections devoted to transcriptional control of neural development, brain function and transcriptional dysregulation induced neurological diseases.With a chapter written by Nobel laureate Eric Kandel, this is essential reading for neurobiologists, geneticists, biochemists, cell biologists, ne 606 $aTranscription factors 606 $aNeural stem cells 608 $aElectronic books. 615 0$aTranscription factors. 615 0$aNeural stem cells. 676 $a616.8042 701 $aThiel$b Gerald$0911727 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144556803321 996 $aTranscription factors in the nervous system$92041691 997 $aUNINA