LEADER 05010nam 22005894a 450 001 9910144556403321 005 20170810191523.0 010 $a1-280-72356-4 010 $a9786610723560 010 $a3-527-60880-X 010 $a3-527-60854-0 035 $a(CKB)1000000000377176 035 $a(EBL)481960 035 $a(OCoLC)609855490 035 $a(SSID)ssj0000289537 035 $a(PQKBManifestationID)11222692 035 $a(PQKBTitleCode)TC0000289537 035 $a(PQKBWorkID)10404023 035 $a(PQKB)11481270 035 $a(MiAaPQ)EBC481960 035 $a(EXLCZ)991000000000377176 100 $a20070718d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAutophagy in immunity and infection$b[electronic resource] $ea novel immune effector /$fedited by Vojo Deretic 210 $aWeinheim $cWiley-VCH$dc2006 215 $a1 online resource (288 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31450-4 320 $aIncludes bibliographical references and index. 327 $aAutophagy in Immunity and Infection; Contents; Preface; Foreword; List of Contributors; Color Plates; Part I Introduction to Autophagy; 1 Overview of Autophagy; 1.1 Overview of Autophagy; 1.2 The Discovery of Autophagy; 1.3 Mechanistic Aspects of Autophagy; 1.3.1 Induction; 1.3.2 Cargo Selection and Packaging; 1.3.3 Vesicle Nucleation; 1.3.4 Vesicle Expansion and Completion; 1.3.5 Retrieval; 1.3.6 Targeting, Docking and Fusion of the Vesicle with the Lysosome/Vacuole; 1.3.7 Breakdown of the Vesicle and its Cargo; 1.4 Autophagy and Immunity; References 327 $a2 Cell Biology and Biochemistry of Autophagy2.1 Introduction; 2.2 Autophagic Pathway; 2.2.1 Formation of Autophagosomes; 2.2.2 Fusion of AV with Endocytic Pathways and Maturation; 2.2.3 Endosomes and Lysosomes; 2.3 Regulation of Mammalian Autophagy by Amino Acids and Hormones; 2.3.1 Amino Acids; 2.3.2 Hormones; 2.3.3 Longer-term Regulation; 2.3.4 The Nutrient Sensor Target of Rapamycin (TOR); 2.3.5 Upstream of TOR; 2.3.6 Downstream of TOR; 2.4 Methods to Measure Autophagy; 2.4.1 Microscopic Methods; 2.4.1.1 Electron Microscopy; 2.4.1.2 Light Microscopy; 2.4.2 Biochemical Methods 327 $a2.4.2.1 Formation and Induction2.4.2.2 Fusion; 2.4.2.3 Purification of Autophagosomes from Rat Liver; 2.4.2.4 Inhibition of Autophagy; 2.4.2.5 Common Questions; 2.4.3 Summary and Outlook; References; 3 Transgenic Models of Autophagy; 3.1 Molecular Mechanism of Mammalian Autophagy; 3.1.1 Atg12 Conjugation System; 3.1.2 Atg8/Microtubule-associated Protein 1 Light Chain 3 (LC3) Conjugation System; 3.1.3 Class III Phosphatidylinositol-3-kinase (PI3K) Complex; 3.1.4 Atg1 Kinase Complex; 3.1.5 Other Factors; 3.2 Autophagy Indicator Mice: Green Fluorescent Protein (GFP)-LC3 Transgenic Mice 327 $a3.3 Mouse Models Deficient for Autophagy-related Genes3.3.1 Atg5-deficient Mice; 3.3.2 Atg7-deficient Mice; 3.3.3 Beclin 1-deficient Mice; 3.4 Concluding Remarks; References; 4 Autophagy in Disease and Aging; 4.1 Introduction; 4.2 Autophagy in Neurodegenerative Disorders; 4.2.1 Protein Misfolding and Aggregation; 4.2.2 Parkinson's Disease; 4.2.3 Alzheimer's Disease; 4.2.4 Huntington's Disease; 4.2.5 Prion Diseases; 4.2.6 Niemann-Pick Type C; 4.3 Autophagy and Cancer; 4.3.1 Proteolysis of long-lived Proteins and Effect of Nutrient Deprivation in Cancer Cells 327 $a4.3.2 Autophagic Cell Death in Response to Anticancer Treatment4.3.3 Molecular Mechanisms; 4.3.3.1 Beclin 1; 4.3.3.2 PI3K-Akt-mTOR Pathway; 4.3.4 Possible Therapeutic Attempts; 4.4 Myopathies; 4.4.1 Danon Disease; 4.4.2 XMEA; 4.4.3 Rimmed Vacuolar Myopathies; 4.4.4 Other Myopathies; 4.4.5 Cardiomyopathies and Myocardial Cell Death; 4.5 Liver Diseases; 4.6 Diabetes Mellitus; 4.7 Aging; 4.7.1 Changes in Protein Degradation with Age; 4.7.2 Age-related Changes in Autophagy; 4.7.3 Consequences of the Failure of Autophagy in Aging; 4.7.4 Slowing Down Aging? 327 $a4.8 Concluding Remarks and Pending Questions 330 $aThis first book to cover this new topic at the interface of cell biology, immunology and infection biology offers a unique insight as to how the innate and possibly the adaptive immune system are shaped by cellular mechanisms. Following a comprehensive introduction to autophagy, the work features cellular mechanisms and medical implications, structured according to all major pathogens, while also covering emerging infectious diseases, such as tuberculosis. Edited by one of the authors of a groundbreaking paper on this topic. 606 $aPhagocytosis 608 $aElectronic books. 615 0$aPhagocytosis. 676 $a616.079 701 $aDeretic$b Vojo$0992998 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144556403321 996 $aAutophagy in immunity and infection$92273867 997 $aUNINA