LEADER 05550nam 2200685Ia 450 001 9910144520903321 005 20170815113612.0 010 $a0-470-74078-7 010 $a1-282-34579-6 010 $a9786612345791 010 $a0-470-02491-7 035 $a(CKB)1000000000579448 035 $a(EBL)406482 035 $a(OCoLC)476225742 035 $a(SSID)ssj0000108978 035 $a(PQKBManifestationID)11132778 035 $a(PQKBTitleCode)TC0000108978 035 $a(PQKBWorkID)10045503 035 $a(PQKB)10017534 035 $a(MiAaPQ)EBC406482 035 $a(EXLCZ)991000000000579448 100 $a20080902d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBasic biostatistics for geneticists and epidemiologists$b[electronic resource] $ea practical approach /$fRobert C. Elston, William D. Johnson 210 $aChichester, U.K. $cJohn Wiley & Sons$d2008 215 $a1 online resource (385 p.) 300 $aDescription based upon print version of record. 311 $a0-470-02489-5 311 $a0-470-02490-9 320 $aIncludes bibliographical references and index. 327 $aBasic Biostatistics for Geneticists and Epidemiologists; CONTENTS; PREFACE; 1 INTRODUCTION: THE ROLE AND RELEVANCE OF STATISTICS, GENETICS AND EPIDEMIOLOGY IN MEDICINE; Why Biostatistics?; What Exactly Is (Are) Statistics?; Reasons for Understanding Statistics; What Exactly is Genetics?; What Exactly is Epidemiology?; How Can a Statistician Help Geneticists and Epidemiologists?; Disease Prevention versus Disease Therapy; A Few Examples: Genetics, Epidemiology and Statistical Inference; Summary; References; 2 POPULATIONS, SAMPLES, AND STUDY DESIGN; The Study of Cause and Effect 327 $aPopulations, Target Populations and Study UnitsProbability Samples and Randomization; Observational Studies; Family Studies; Experimental Studies; Quasi-Experimental Studies; Summary; Further Reading; Problems; 3 DESCRIPTIVE STATISTICS; Why Do We Need Descriptive Statistics?; Scales of Measurement; Tables; Graphs; Proportions and Rates; Relative Measures of Disease Frequency; Sensitivity, Specificity and Predictive Values; Measures of Central Tendency; Measures of Spread or Variability; Measures of Shape; Summary; Further Reading; Problems; 4 THE LAWS OF PROBABILITY; Definition of Probability 327 $aThe Probability of Either of Two Events: A or BThe Joint Probability of Two Events: A and B; Examples of Independence, Nonindependence and Genetic Counseling; Bayes' Theorem; Likelihood Ratio; Summary; Further Reading; Problems; 5 RANDOM VARIABLES AND DISTRIBUTIONS; Variability and Random Variables; Binomial Distribution; A Note about Symbols; Poisson Distribution; Uniform Distribution; Normal Distribution; Cumulative Distribution Functions; The Standard Normal (Gaussian) Distribution; Summary; Further Reading; Problems; 6 ESTIMATES AND CONFIDENCE LIMITS; Estimates and Estimators 327 $aNotation for Population Parameters, Sample Estimates, and Sample EstimatorsProperties of Estimators; Maximum Likelihood; Estimating Intervals; Distribution of the Sample Mean; Confidence Limits; Summary; Problems; 7 SIGNIFICANCE TESTS AND TESTS OF HYPOTHESES; Principle of Significance Testing; Principle of Hypothesis Testing; Testing a Population Mean; One-Sided versus Two-Sided Tests; Testing a Proportion; Testing the Equality of Two Variances; Testing the Equality of Two Means; Testing the Equality of Two Medians; Validity and Power; Summary; Further Reading; Problems 327 $a8 LIKELIHOOD RATIOS, BAYESIAN METHODS AND MULTIPLE HYPOTHESESLikelihood Ratios; Bayesian Methods; Bayes' Factors; Bayesian Estimates and Credible Intervals; The Multiple Testing Problem; Summary; Problems; 9 THE MANY USES OF CHI-SQUARE; The Chi-Square Distribution; Goodness-of-Fit Tests; Contingency Tables; Inference About the Variance; Combining p-Values; Likelihood Ratio Tests; Summary; Further Reading; Problems; 10 CORRELATION AND REGRESSION; Simple Linear Regression; The Straight-Line Relationship When There is Inherent Variability; Correlation; Spearman's Rank Correlation 327 $aMultiple Regression 330 $aAnyone who attempts to read genetics or epidemiology research literature needs to understand the essentials of biostatistics. This book, a revised new edition of the successful Essentials of Biostatistics has been written to provide such an understanding to those who have little or no statistical background and who need to keep abreast of new findings in this fast moving field. Unlike many other elementary books on biostatistics, the main focus of this book is to explain basic concepts needed to understand statistical procedures. This Book:Surveys basic statistical methods use 606 $aMedical statistics 606 $aMedical genetics$xStatistical methods 606 $aEpidemiology$xStatistical methods 608 $aElectronic books. 615 0$aMedical statistics. 615 0$aMedical genetics$xStatistical methods. 615 0$aEpidemiology$xStatistical methods. 676 $a570.15195 676 $a610.72 676 $a614.40727 700 $aElston$b Robert C.$f1932-$0508215 701 $aJohnson$b William Davis$f1941-$0897409 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144520903321 996 $aBasic biostatistics for geneticists and epidemiologists$92004955 997 $aUNINA