LEADER 03510nam 22006254a 450 001 9910144448403321 005 20170815115654.0 010 $a1-281-83126-3 010 $a9786611831264 010 $a0-470-39927-9 010 $a0-470-39926-0 035 $a(CKB)1000000000557011 035 $a(EBL)362114 035 $a(OCoLC)476191902 035 $a(SSID)ssj0000218737 035 $a(PQKBManifestationID)11175958 035 $a(PQKBTitleCode)TC0000218737 035 $a(PQKBWorkID)10221130 035 $a(PQKB)10279419 035 $a(MiAaPQ)EBC362114 035 $a(EXLCZ)991000000000557011 100 $a20080403d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPathway analysis for drug discovery$b[electronic resource] $ecomputational infrastructure and applications /$fedited by Anton Yuryev 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2008 215 $a1 online resource (332 p.) 225 1 $aWiley series on technologies for the pharmaceutical industry 300 $aDescription based upon print version of record. 311 $a0-470-10705-7 320 $aIncludes bibliographical references and index. 327 $aPATHWAY ANALYSIS FOR DRUG DISCOVERY; CONTENTS; Preface; Contributors; 1 Introduction to Pathway Analysis; 2 Software Infrastructure and Data Model for Pathway Analysis; 3 Automatic Pathway Inference in Heterogeneous Biological Association Networks; 4 Algorithmic Basis for Pathway Visualization; 5 Pathway Analysis of High-Throughput Experimental Data; 6 Integrative Pathway Analysis of Disease Molecular Data; 7 Whole-Genome Expression Profiling of Papillary Serous Ovarian Cancer: Activated Pathways, Potential Targets, and Noise; 8 Mammalian Proteome and Toxicant Network Analysis 327 $a9 Unraveling Mechanisms of Toxicity with the Power of Pathways: ToxWiz Tool as an Illustrative Example10 Impact of Chemistry Information on Pathway Analysis; 11 Propagation of Concentration Perturbations in Equilibrium Protein Binding Networks; 12 An Adaptive System Model of the Yeast Glucose Sensor System; 13 Present and Future of Pathway Analysis in Drug Discovery; Index 330 $aThis book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in rela 410 0$aWiley series on technologies for the pharmaceutical industry. 606 $aDrug development$xData processing 606 $aDNA microarrays$xData processing 606 $aComputational biology 608 $aElectronic books. 615 0$aDrug development$xData processing. 615 0$aDNA microarrays$xData processing. 615 0$aComputational biology. 676 $a615.19 676 $a615/.190285 701 $aYuryev$b Anton$0895645 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144448403321 996 $aPathway analysis for drug discovery$92000780 997 $aUNINA LEADER 05041nam 2200889Ia 450 001 9910783263603321 005 20230207223542.0 010 $a0-8147-7335-4 010 $a1-4175-6865-8 024 7 $a10.18574/9780814773352 035 $a(CKB)1000000000031444 035 $a(EBL)865890 035 $a(OCoLC)782878059 035 $a(SSID)ssj0000231961 035 $a(PQKBManifestationID)11216203 035 $a(PQKBTitleCode)TC0000231961 035 $a(PQKBWorkID)10207998 035 $a(PQKB)10483442 035 $a(SSID)ssj0000667935 035 $a(PQKBManifestationID)12330057 035 $a(PQKBTitleCode)TC0000667935 035 $a(PQKBWorkID)10699190 035 $a(PQKB)24213773 035 $a(MiAaPQ)EBC865890 035 $a(OCoLC)57361509 035 $a(MdBmJHUP)muse10423 035 $a(DE-B1597)547044 035 $a(DE-B1597)9780814773352 035 $a(Au-PeEL)EBL865890 035 $a(CaPaEBR)ebr10078446 035 $a(EXLCZ)991000000000031444 100 $a20030717d2004 uy 0 101 0 $aeng 135 $aurnn#---|u||u 181 $ctxt 182 $cc 183 $acr 200 10$aRace war$b[electronic resource] $ewhite supremacy and the Japanese attack on the British Empire /$fGerald Horne 210 $aNew York $cNew York University Press$dc2004 215 $a1 online resource (430 p.) 300 $aDescription based upon print version of record. 311 0 $a0-8147-3641-6 311 0 $a0-8147-3640-8 320 $aIncludes bibliographical references (p. 329-377) and index. 327 $tFront matter --$tContents --$tPreface --$tAcknowledgments --$tIntroduction --$t1 To Be of ?Pure European Descent? --$t2 The Asiatic Black Man? --$t3 Race/War --$t4 Internment --$t5 War/Race --$t6 Race Reversed/Gender Transformed --$t7 The White Pacific --$t8 Asians versus White Supremacy --$t9 Race at War --$t10 Race World --$tConclusion --$tEpilogue --$tNotes --$tIndex --$tAbout the Author 330 $aJapan?s lightning march across Asia during World War II was swift and brutal. Nation after nation fell to Japanese soldiers. How were the Japanese able to justify their occupation of so many Asian nations? And how did they find supporters in countries they subdued and exploited? Race War! delves into submerged and forgotten history to reveal how European racism and colonialism were deftly exploited by the Japanese to create allies among formerly colonized people of color. Through interviews and original archival research on five continents, Gerald Horne shows how race played a key?and hitherto ignored?;role in each phase of the war. During the conflict, the Japanese turned white racism on its head portraying the war as a defense against white domination in the Pacific. We learn about the reverse racial hierarchy practiced by the Japanese internment camps, in which whites were placed at the bottom of the totem pole, under the supervision of Chinese, Korean, and Indian guards?an embarrassing example of racial payback that was downplayed by the defeated Japanese and the humiliated Europeans and Euro-Americans. Focusing on the microcosmic example of Hong Kong but ranging from colonial India to New Zealand and the shores of the U.S., Gerald Horne radically retells the story of the war. From racist U.S. propaganda to Black Nationalist open support of Imperial Japan, information about the effect of race on U.S. and British policy is revealed for the first time. This revisionist account of the war draws connections between General Tojo, Malaysian freedom fighters, and Elijah Muhammed of the Nation of Islam and shows how white racism encouraged and enabled Japanese imperialism. In sum, Horne demonstrates that the retreat of white supremacy was not only driven by the impact of the Cold War and the energized militancy of Africans and African-Americans but by the impact of the Pacific War as well, as a chastened U.S. and U.K. moved vigorously after this conflict to remove the conditions that made Japan's success possible. 606 $aWorld War, 1939-1945$zPacific Area 606 $aWorld War, 1939-1945$zAsia 606 $aWorld War, 1939-1945$zJapan 606 $aCaucasian race$xSocial conditions 606 $aRacism$zJapan 606 $aRacism$zAsia 606 $aRacism$zPacific Area 607 $aAsia$xRace relations 607 $aPacific Area$xRace relations 607 $aJapan$xRace relations 610 $aracism. 610 $asecond. 610 $ashaped. 610 $awar. 610 $aworld. 615 0$aWorld War, 1939-1945 615 0$aWorld War, 1939-1945 615 0$aWorld War, 1939-1945 615 0$aCaucasian race$xSocial conditions. 615 0$aRacism 615 0$aRacism 615 0$aRacism 676 $a940.53/089/009171241 700 $aHorne$b Gerald$0850651 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910783263603321 996 $aRace war$93855431 997 $aUNINA