LEADER 05702nam 2200781Ia 450 001 9910144336203321 005 20230721030210.0 010 $a9780470173381 010 $a1-281-22146-5 010 $a9786611221461 010 $a0-470-17338-6 010 $a0-470-17337-8 035 $a(CKB)1000000000376200 035 $a(EBL)331434 035 $a(OCoLC)437198694 035 $a(SSID)ssj0000238600 035 $a(PQKBManifestationID)11200410 035 $a(PQKBTitleCode)TC0000238600 035 $a(PQKBWorkID)10234321 035 $a(PQKB)11780062 035 $a(MiAaPQ)EBC331434 035 $a(Au-PeEL)EBL331434 035 $a(CaPaEBR)ebr10226781 035 $a(CaONFJC)MIL122146 035 $a(EXLCZ)991000000000376200 100 $a20070220d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aRisk assessment for chemicals in drinking water /$fedited by Robert A. Howd, Anna M. Fan 210 1$aHoboken, New Jersey :$cWiley-Interscience,$d[2008] 210 4$d©2008 215 $a1 online resource (389 p.) 300 $aDescription based upon print version of record. 311 1 $a9780471723448 311 1 $a0-471-72344-4 320 $aIncludes bibliographical references and index. 327 $aRISK ASSESSMENT FOR CHEMICALS IN DRINKING WATER; CONTENTS; Contributors; Foreword; Preface; 1 Introduction to Drinking Water Risk Assessment; Development of Drinking Water Regulations; The Risk Assessment Process; Public Perceptions and the Precautionary Principle; References; 2 Summary of the Development of Federal Drinking Water Regulations and Health-Based Guidelines for Chemical Contaminants; Selecting Candidates for Regulatory Consideration; Key Components for Regulatory Development; Development of Regulatory Values; Nonregulatory Options; References 327 $a3 Interpretation of Toxicologic Data for Drinking Water Risk AssessmentAnimal Toxicity Studies; Human Toxicity Studies; Conclusions; References; 4 Exposure Source and Multiroute Exposure Considerations for Risk Assessment of Drinking Water Contaminants; Exposure Source Considerations in Risk Assessment; Routes of Exposure and Dose Calculations; References; 5 Toxicokinetics for Drinking Water Risk Assessment; Evaluation of Toxicity Data; Toxicokinetics: PBPK Modeling; Risk Assessment; Conclusions; References; 6 Health Risk Assessment of Chemical Mixtures in Drinking Water 327 $aDrinking Water Mixture ConcernsEstimating Exposures to Multiple Chemicals in Drinking Water; Toxicological Concepts for Joint Toxicity; Chemical Mixtures Risk Assessment Methods; New Approaches for Assessing Risk from Exposure to Drinking Water Mixtures; Conclusions; References; 7 Protection of Infants, Children, and Other Sensitive Subpopulations; Factors Influencing Differences in Susceptibility Between Infants and Children and Adults; Critical Systems and Periods in Development; Age at Exposure and Susceptibility to Carcinogens 327 $aDrinking Water Standards Developed to Protect Sensitive SubpopulationsReferences; 8 Risk Assessment for Essential Nutrients; Assessment Approaches; Comparison of Guideline Values; Risk Assessment Recommendations; References; 9 Risk Assessment for Arsenic in Drinking Water; Occurrence and Exposure; Metabolism; Health Effects; Risk Assessment; Conclusions; References; 10 Risk Assessment for Chloroform, Reconsidered; Carcinogenic Effects; Noncancer Toxic Effects; Mechanisms of Carcinogenicity; Regulation of Cancer Risk; Discussion; References 327 $a11 Risk Assessment of a Thyroid Hormone Disruptor: PerchlorateBackground; Human Health Risk Assessment; Risk Characterization and Conclusions; References; 12 Emerging Contaminants in Drinking Water: A California Perspective; Emerging Chemicals of the Recent Past; Newer Emerging Contaminants; Future Emerging Chemicals; Conclusions; References; 13 U.S. EPA Drinking Water Field Office Perspectives and Needs for Risk Assessment; The Nature of Regulatory Risk Assessments; Use of Drinking Water Risk Information in EPA Field Offices; Conclusions; References 327 $a14 Risk Assessment: Emerging Issues, Recent Advances, and Future Challenges 330 $aA comprehensive reference on state-of-the-art risk assessment methodologies for drinking waterRisk Assessment for Chemicals in Drinking Water discusses the major steps and goals in risk assessments and suggests ways to improve the methodologies and accuracy, while consolidating up-to-date information on the current principles and practices in one authoritative reference. After an enlightening overview of risk assessment practices and regulatory guidelines, it: Includes descriptions of the use of variability analysis, exposure analysis, physiologically based pharmacokinet 606 $aAigua potable$xToxicologia$2lemac 606 $aAigua potable$xContaminació$2lemac 606 $aRiscos per a la salut$xAvaluació$2lemac 606 $aDrinking water$xContamination$xHealth aspects 606 $aHealth risk assessment 615 7$aAigua potable$xToxicologia 615 7$aAigua potable$xContaminació 615 7$aRiscos per a la salut$xAvaluació 615 0$aDrinking water$xContamination$xHealth aspects. 615 0$aHealth risk assessment. 676 $a613.2 676 $a613.2/87 676 $a613.287 702 $aHowd$b Robert A. 702 $aFan$b Anna M.$f1949- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144336203321 996 $aRisk assessment for chemicals in drinking water$92042108 997 $aUNINA