LEADER 05174nam 22006254a 450 001 9910144329103321 005 20170816124433.0 010 $a1-281-31173-1 010 $a9786611311735 010 $a3-527-61248-3 010 $a3-527-61249-1 035 $a(CKB)1000000000376235 035 $a(EBL)481638 035 $a(OCoLC)609855373 035 $a(SSID)ssj0000296865 035 $a(PQKBManifestationID)11253836 035 $a(PQKBTitleCode)TC0000296865 035 $a(PQKBWorkID)10328151 035 $a(PQKB)10578372 035 $a(MiAaPQ)EBC481638 035 $a(EXLCZ)991000000000376235 100 $a20040202d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFreeze-drying$b[electronic resource] 205 $a2nd, completely rev. and extended ed. /$bGeorg-Wilhelm Oetjen, Peter Haseley. 210 $aWeinheim $cWiley-VCH$dc2004 215 $a1 online resource (409 p.) 300 $aDescription based upon print version of record. 311 $a3-527-30620-X 320 $aIncludes bibliographical references and index. 327 $aFreeze-Drying; Table of Contents; Preface; Preface to the First Edition; 1 Foundations and Process Engineering; 1.1 Freezing; 1.1.1 Amount of Heat, Heat Conductivity, Heat Transfer and Cooling Rate; 1.1.2 Structure of Ice, Solutions and Dispersions; 1.1.3 Influence of Excipients; 1.1.4 Freezing of Cells and Bacteria; 1.1.5 Methods of Structure Analysis; 1.1.5.1 Measurements of Electrical Resistance (ER); 1.1.5.2 Differential Thermal Analysis (DTA); 1.1.5.3 Cryomicroscopy; 1.1.5.4 Differential Scanning Calorimetry (DSC); 1.1.5.5 Nuclear Magnetic Resonance 327 $a1.1.5.6 Thermomechanical Analysis (TMA)1.1.5.7 Dielectric Analysis (DEA); 1.1.5.8 X-ray Diffractometry-Raman Spectroscopy; 1.1.6 Changes of Structure in Freezing or Frozen Products; 1.2 Drying; 1.2.1 Main Drying (Sublimation Drying); 1.2.2 Secondary Drying (Desorption Drying); 1.2.3 Temperature and Pressure Measurement; 1.2.4 Water Vapor Transport During Drying; 1.2.5 Collapse and Recrystallization; 1.2.6 Drying Processes Without Vacuum; 1.3 Storage; 1.3.1 Measurement of the Residual Moisture Content (RM); 1.3.1.1 Gravimetric Method; 1.3.1.2 Karl Fischer (KF) Method 327 $a1.3.1.3 Thermogravimetry (TG, TG/MS)1.3.1.4 Infrared Spectroscopy; 1.3.2 Influence of Vial Stoppers on the Residual Moisture Content; 1.3.3 Qualities of the Dry Substances and Their Changes; 1.4 References for Chapter 1; 2 Installation and Equipment Technique; 2.1 Freezing Installation; 2.1.1 Cooling by Liquids: Shell-freezing and Spin-freezing; 2.1.2 Cooled Surfaces; 2.1.3 Product in the Flow of Cold Air, Foaming and Freezing of Extracts and Pulps; 2.1.4 Droplet Freezing in Cold Liquids; 2.1.5 Freezing by Evaporation of Product Water; 2.2 Components of a Freeze-drying Plant 327 $a2.2.1 Installations for Flasks and Manifolds2.2.2 Drying Chambers and Forms of Trays; Trays for Special Applications; 2.2.3 Shelves and their Cooling and Heating; 2.2.4 Water Vapor Condensers; 2.2.5 Refrigerating Systems and Refrigerants; 2.2.6 Vacuum Pumps; 2.2.7 Inlet Venting Filters; 2.2.8 Vacuum Measuring Systems; 2.2.9 Leak Rate Detection; 2.2.10 Process Control Systems; 2.2.11 Problems, Failures and Deviations; 2.3 Installations up to 10 kg Ice Capacity; 2.3.1 Universal Laboratory Plants; 2.3.2 Pilot Plants; 2.3.3 Manipulators and Stoppering Systems for Vials 327 $a2.3.4 Cleaning Installations, Sterilization by Steam and Vaporized Hydrogen Peroxide (VHP®)2.4 Production Plants; 2.4.1 Loading and Unloading Systems; 2.5 Production Plants for Food; 2.5.1 Discontinuous Plants; 2.5.2 Continuous Plants with Tray Transport; 2.5.3 Continuous Plants with Product Transport by Wipers or by Vibration; 2.6 Process Automation; 2.6.1 Prerequisites for Process and Related Plant Automation; 2.6.2 Control of the Process and Related Plant Data by Thermodynamic Data Measured During the Process: Thermodynamic Lyophilization Control (TLC) 327 $a2.6.2.1 Control of the Process Without Temperature Sensors in the Product 330 $aMany modern pharmaceutical and biological products, e.g. blood derivatives, vaccines, cytostatic drugs, antibiotics, bacteria cultures but also consumer goods such as soluble coffee are freeze-dried to transform perishable substances into a form that can be stored and reconstituted to their almost original state without loss of quality.The book describes the up-to-date fundamentals of freeze-drying, not just presenting the process in all its seven steps theoretically, but explaining it with many practical examples. Many years of experience in freeze-drying allow the authors to supply valua 606 $aFreeze-drying 608 $aElectronic books. 615 0$aFreeze-drying. 676 $a615.19 676 $a660/.28426 700 $aOetjen$b Georg-Wilhelm$0889469 701 $aHaseley$b Peter$0289089 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144329103321 996 $aFreeze-drying$92139189 997 $aUNINA