LEADER 05167nam 2200661Ia 450 001 9910144326603321 005 20170816123319.0 010 $a1-280-51964-9 010 $a9786610519644 010 $a3-527-60511-8 010 $a3-527-60424-3 035 $a(CKB)1000000000376393 035 $a(EBL)481563 035 $a(OCoLC)68620079 035 $a(SSID)ssj0000206360 035 $a(PQKBManifestationID)11187300 035 $a(PQKBTitleCode)TC0000206360 035 $a(PQKBWorkID)10227035 035 $a(PQKB)11736358 035 $a(MiAaPQ)EBC481563 035 $a(PPN)159212669 035 $a(EXLCZ)991000000000376393 100 $a20040624d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMulticomponent reactions$b[electronic resource] /$fedited by Jieping Zhu, Hugues Bienayme? 210 $aWeinheim ;$a[Great Britain] $cWiley-VCH$dc2005 215 $a1 online resource (486 p.) 300 $aDescription based upon print version of record. 311 $a3-527-30806-7 320 $aIncludes bibliographical references and index. 327 $aMulticomponent Reactions; Contents; Preface; Contributors; 1 Asymmetric Isocyanide-based MCRs; 1.1 Introduction; 1.2 Racemization Issues; 1.3 Asymmetric Passerini Reactions; 1.3.1 Classical Passerini Reactions; 1.3.2 Passerini-type Reactions; 1.4 Asymmetric Intermolecular Ugi Reactions; 1.4.1 General Remarks; 1.4.2 Chiral Amines; 1.4.2.1 ?-Methylbenzylamines; 1.4.2.2 Ferrocenylamines; 1.4.2.3 Glycosylamines; 1.4.2.4 Esters of ?-amino Acids; 1.4.3 Chiral Isocyanides, Carboxylic Acids and Carbonyl Compounds; 1.4.4 Chiral Cyclic Imines; 1.5 Asymmetric Intramolecular Ugi Reactions 327 $a1.5.1 With ?-Amino Acids1.5.2 With Other Amino Acids; 1.5.3 With Keto Acids; 1.6 Other Asymmetric Isonitrile-based Multicomponent Reactions; 1.6.1 Tandem Ugi or Passerini Reaction/Intramolecular Diels-Alder (IMDA) Cyclizations; 1.6.2 Other Asymmetric Isonitrile-based Multicomponent Reactions; References; 2 Post-condensation Modifications of the Passerini and Ugi Reactions; 2.1 Convertible Isocyanides; 2.2 I-MCR Post-condensation Reactions in Synthesis of Open-chain Products; 2.2.1 Passerini 3CR + O-Deacylation; 2.2.2 Passerini-3CR + N-Deprotection + O N Acyl Migration 327 $a2.2.3 Ugi-4CR + Oxidation2.2.4 Ugi-4CR + Hydrolysis; 2.2.5 Ugi-4CR in Peptide Synthesis; 2.3 I-MCR Post-condensation Reactions in the Synthesis of Heterocycles; 2.3.1 Three-, Four-, and Five-membered Rings and their Benzo-fused Derivatives; 2.3.1.1 Oxiranes and ?-Lactams by Passerini-3CR + O- or N-alkylation; 2.3.1.2 ?-Lactams and Succinimides by Ugi-4CR + C-Alkylation; 2.3.1.3 Furans, Pyrroles, and Indoles by Passerini-3CR or Ugi-4CR and Knoevenagel Condensation; 2.3.1.4 Butenolides by Passerini-3CR and the Horner-Emmons-Wadsworth Reaction 327 $a2.3.1.5 Pyrroles and ?-Lactams by Ugi-4CR and Hydrolysis2.3.1.6 Indazolinones by Ugi-4CR with N-deprotection and Aromatic Nucleophilic Substitution; 2.3.1.7 Oxazole Derivatives and Imidazoles by Passerini-3CR or Ugi-4CR and Davidson Cyclization; 2.3.1.8 2-Imidazolines, Imidazolidin-2-ones and Benzimidazoles by Ugi-4CR with N-Deprotection and Cyclization; 2.3.1.9 Spiroimidazolones and Spirothioimidohydantoins by Ugi-4CR and Further Transformations; 2.3.2 Six-membered Rings and Their Benzo-fused Systems; 2.3.2.1 Pyridine Derivatives by Ugi-4CR and Aldol-type Condensation 327 $a2.3.2.2 Pyridazine Derivatives by Ugi-4CR and Knoevenagel Condensation2.3.2.3 Phthalazine Derivatives by Ugi-4CR with N-Deprotection and Cyclization; 2.3.2.4 Piperazines and Pyrazin-2-ones by Ugi-4CR and Cyclization; 2.3.2.5 Ketopiperazines, 2,5-Diketopiperazines and Quinoxalines by Ugi-4CR with N-Deprotection and Intramolecular Amide Bond Formation; 2.3.2.6 2,5-Diketopiperazines and Morpholines from Bifunctional Ugi-4CR Reagents; 2.3.3 Seven-membered Rings and Their Benzo-fused Systems; 2.3.3.1 Azepines by Ugi-4CR and Ring-closing Metathesis 327 $a2.3.3.2 1,4-Benzodiazepine-5-ones by Ugi-4CR with N-Deprotection and Aromatic Nucleophilic Substitution 330 $aIn the very first book on this hot topic, the expert editors and authors present a comprehensive overview of these elegant reactions. From the contents:Organoboron compoundsFree-radical mediated multicomponent coupling reactionsApplications in drug discoveryMetal catalyzed reactionsTotal synthesis of natural productsAsymmetric isocyanide-based reactionsThe Biginelli reactionAsymmetric isocyanide-based reactionsThe Domino-Knoevenagel-Hetero-Diels-Alder Re 606 $aCatalysis 606 $aChemical reactions 606 $aChemistry, Organic 615 0$aCatalysis. 615 0$aChemical reactions. 615 0$aChemistry, Organic. 676 $a547.2 686 $a35.51$2bcl 701 $aBienayme?$b Hugues$0935707 701 $aZhu$b Jieping$0935708 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144326603321 996 $aMulticomponent reactions$92107744 997 $aUNINA