LEADER 05638nam 2200721Ia 450 001 9910144324903321 005 20170810192815.0 010 $a1-280-52116-3 010 $a9786610521166 010 $a3-527-60682-3 010 $a3-527-60654-8 010 $a1-60119-357-2 035 $a(CKB)1000000000376396 035 $a(EBL)482043 035 $a(OCoLC)70053691 035 $a(SSID)ssj0000071519 035 $a(PQKBManifestationID)11123236 035 $a(PQKBTitleCode)TC0000071519 035 $a(PQKBWorkID)10091553 035 $a(PQKB)11146263 035 $a(MiAaPQ)EBC482043 035 $a(EXLCZ)991000000000376396 100 $a20041002d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBoronic acids$b[electronic resource] $epreparation and applications in organic synthesis and medicine /$fedited by Dennis G. Hall 210 $aWeinheim $cWiley-VCH ;$aChichester $cJohn Wiley$dc2005 215 $a1 online resource (577 p.) 300 $aDescription based upon print version of record. 311 $a3-527-30991-8 320 $aIncludes bibliographical references and index. 327 $aBoronic Acids; Table of Contents; Preface; List of Authors; List of Abbreviations; 1 Structure, Properties, and Preparation Of Boronic Acid Derivatives. Overview of Their Reactions and Applications; 1.1 Introduction; 1.2 Structure and Properties of Boronic Acid Derivatives; 1.2.1 General Types and Nomenclature of Boronic Acid Derivatives; 1.2.2 Boronic Acids; 1.2.2.1 Structure and Bonding; 1.2.2.2 Physical Properties and Handling; 1.2.2.3 Safety Considerations; 1.2.2.4 Acidic Character; 1.2.2.5 Chemical Stability; 1.2.3 Boronic Acid Derivatives; 1.2.3.1 Boroxines; 1.2.3.2 Boronic Esters 327 $a1.2.3.3 Dialkoxyboranes and other Heterocyclic Boranes1.2.3.4 Diboronyl Esters; 1.2.3.5 Azaborolidines and other Boron Heterocycles; 1.2.3.6 Dihaloboranes and Monoalkylboranes; 1.2.3.7 Trifluoroborate Salts; 1.3 Synthesis of Boronic Acids and their Esters; 1.3.1 Arylboronic Acids; 1.3.1.1 Electrophilic Trapping of Arylmetal Intermediates with Borates; 1.3.1.2 Transmetallation of Aryl Silanes and Stannanes; 1.3.1.3 Coupling of Aryl Halides with Diboronyl Reagents; 1.3.1.4 Direct Boronylation by Transition Metal-catalyzed Aromatic C-H Functionalization; 1.3.1.5 Other Methods 327 $a1.3.2 Diboronic Acids1.3.3 Heterocyclic Boronic Acids; 1.3.4 Alkenylboronic Acids; 1.3.4.1 Electrophilic Trapping of Alkenymetal Intermediates with Borates; 1.3.4.2 Transmetallation Methods; 1.3.4.3 Transition-metal Catalyzed Coupling between Alkenyl Halides/Triflates and Diboronyl Reagents; 1.3.4.4 Hydroboration of Alkynes; 1.3.4.5 Alkene Metathesis; 1.3.4.6 Other Methods; 1.3.5 Alkynylboronic Acids; 1.3.6 Alkylboronic Acids; 1.3.7 Allylic Boronic Acids; 1.3.8 Chemoselective Transformations of Compounds containing a Boronic Acid (Ester) Substituent; 1.3.8.1 Oxidative Methods 327 $a1.3.8.2 Reductive Methods1.3.8.3 Generation and Reactions of ?-Boronyl-substituted Carbanions and Radicals; 1.3.8.4 Reactions of (?-Haloalkyl)boronic Esters; 1.3.8.5 Other Transformations; 1.4 Isolation and Characterization; 1.4.1 Chromatography and Recrystallization; 1.4.2 Solid Supports for Boronic Acid Immobilization and Purification; 1.4.2.1 Diethanolaminomethyl Polystyrene; 1.4.2.2 Other Solid-supported Diol Resins; 1.4.2.3 Soluble Diol Approaches; 1.4.3 Analytical and Spectroscopic Methods for Boronic Acid Derivatives; 1.4.3.1 Melting Points and Combustion Analysis 327 $a1.4.3.2 Mass Spectrometry1.4.3.3 Nuclear Magnetic Resonance Spectroscopy; 1.4.3.4 Other Spectroscopic Methods; 1.5 Overview of the Reactions of Boronic Acid Derivatives; 1.5.1 Metallation and Metal-catalyzed Protodeboronation; 1.5.2 Oxidative Replacement of Boron; 1.5.2.1 Oxygenation; 1.5.2.2 Amination; 1.5.2.3 Halogenation; 1.5.3 Carbon-Carbon Bond forming Processes; 1.5.3.1 Palladium-catalyzed Cross-coupling with Carbon Halides (Suzuki Coupling); 1.5.3.2 Allylation of Carbonyl Compounds; 1.5.3.3 Uncatalyzed Additions to Imines and Iminiums 327 $a1.5.3.4 Rhodium-catalyzed Additions to Aldehydes and Alkenes 330 $aFor the first time, the whole field of organoboronic acids is presented in one comprehensive handbook.Professor Dennis Hall, a rising star within the community, covers all aspects of this important substance class, including applications in chemistry, biology and medicine.Starting with an introduction to the structure, properties, and preparation of boronic acid derivatives, together with an overview of their reactions and applications, the book goes on to look at metal-catalyzed borylation of alkanes and arenas, coupling reactions and rhodium-catalyzed additions of boronic acids to al 606 $aOrganic acids 606 $aOrganoboron compounds 606 $aOrganic acids$xTherapeutic use 606 $aOrganoboron compounds$xTherapeutic use 606 $aOrganic acids$xSynthesis 606 $aOrganoboron compounds$xSynthesis 608 $aElectronic books. 615 0$aOrganic acids. 615 0$aOrganoboron compounds. 615 0$aOrganic acids$xTherapeutic use. 615 0$aOrganoboron compounds$xTherapeutic use. 615 0$aOrganic acids$xSynthesis. 615 0$aOrganoboron compounds$xSynthesis. 676 $a547.05671 701 $aHall$b Dennis$0924948 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144324903321 996 $aBoronic acids$92075995 997 $aUNINA