LEADER 03843nam 2200661 a 450 001 9910144297703321 005 20170816150046.0 010 $a1-282-34771-3 010 $a9786612347719 010 $a0-470-51408-6 010 $a0-470-51409-4 035 $a(CKB)1000000000376481 035 $a(EBL)470458 035 $a(OCoLC)609849357 035 $a(SSID)ssj0000298869 035 $a(PQKBManifestationID)11248022 035 $a(PQKBTitleCode)TC0000298869 035 $a(PQKBWorkID)10238418 035 $a(PQKB)10018076 035 $a(MiAaPQ)EBC470458 035 $a(EXLCZ)991000000000376481 100 $a19910118d1991 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHost-guest molecular interactions$b[electronic resource] $efrom chemistry to biology 210 $aChichester ;$aNew York $cWiley$d1991 215 $a1 online resource (290 p.) 225 1 $aCiba Foundation symposium ;$v158 300 $aProceedings of the Symposium on Host-Guest Molecular Interactions: from Chemistry to Biology held at the Ciba Foundation, London, Jul. 3-5, 1990. 311 $a0-471-92958-1 320 $aIncludes bibliographical references and indexes. 327 $aHOST-GUEST MOLECULAR INTERACTIONS: FROM CHEMISTRY TO BIOLOGY; Contents; Introduction; Molecular self-assembly processes; Self-assembly in supramolecular systems; General discussion I : Flexibility or rigidity?; Host-guest interactions in thin membranes: selective ion transport and transduction into electronic signals; Molecular recognition and molecular sensors; The natural design of vancomycin family antibiotics to bind to their target peptides; General discussion II : Crystals as supramolecules; Molecular devices and sensors; Clefts as receptor and enzyme analogues; Enzyme mimics 327 $aBinding of antibiotics to DNADesign of sequence-specific bifunctional nucleic acid ligands; Synthesis and biochemical studies of dithioate DNA; Conformational flexibility and protein specificity; Protein design: template-assembled synthetic proteins; General discussion III Transition state theory and energy requirements for reaction; Binding of peptides to proteins: an exercise in molecular design; Involvement of water in host-guest interactions; Molecular modelling approaches to host-guest complexes; Summing-up; Index of contributors; Subject index 330 $aComposed of contributions from experts in the chemical and biological sciences, it explores host-guest molecular interactions leading to the formation of molecular assemblies containing two or more species. Exciting applications are emerging in this field and it is expected that improved understanding of the interactions in synthetic host molecule complexes will lead to a better understanding of the more complex biological systems. Topics include biomimetic chemistry, preorganization, self-assembly, template-directed synthesis, antibiotic binding to peptides and DNA, interactions between prote 410 0$aCiba Foundation symposium ;$v158. 606 $aLigand binding (Biochemistry)$vCongresses 606 $aDrugs$xDesign$vCongresses 606 $aProtein engineering$vCongresses 606 $aProtein binding$vCongresses 608 $aElectronic books. 615 0$aLigand binding (Biochemistry) 615 0$aDrugs$xDesign 615 0$aProtein engineering 615 0$aProtein binding 676 $a574.19 676 $a574.19245 676 $a574.88 712 12$aSymposium on Host-Guest Molecular Interactions: from Chemistry to Biology$f(1990 :$eCiba Foundation) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144297703321 996 $aHost-guest molecular interactions$92289394 997 $aUNINA