LEADER 03328nam 2200601 a 450 001 9910144297403321 005 20170816122223.0 010 $a1-282-34772-1 010 $a9786612347726 010 $a0-470-51410-8 010 $a0-470-51411-6 035 $a(CKB)1000000000376482 035 $a(EBL)470479 035 $a(OCoLC)609849398 035 $a(SSID)ssj0000291045 035 $a(PQKBManifestationID)11212190 035 $a(PQKBTitleCode)TC0000291045 035 $a(PQKBWorkID)10248798 035 $a(PQKB)10046647 035 $a(MiAaPQ)EBC470479 035 $a(EXLCZ)991000000000376482 100 $a19911220d1991 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCatalytic antibodies$b[electronic resource] 210 $aChichester ;$aNew York $cWiley$d1991 215 $a1 online resource (272 p.) 225 1 $aCiba Foundation symposium ;$v159 300 $a"A Wiley-Interscience publication." 311 $a0-471-92962-X 320 $aIncludes bibliographical references and indexes. 327 $aCATALYTIC ANTIBODIES; Contents; Introduction; A catalytic antibody uses a multistep kinetic sequence; Structural aspects of antibodies and antibody-antigen complexes; Nuclear magnetic resonance studies of antibody-antigen interactions; Modelling antibody combining sites: a review; Approaches to the design of semisynthetic metal-dependent catalytic antibodies; Construction of combinatorial antibody expression libraries in Escherichia coli; Catalytic antibodies: contributions from engineering and expression in Escherichia coli 327 $aThe generation of antibody combining sites containing catalytic residuesGeneral discussion I; Screening combinatorial antibody libraries for catalytic acyl transfer reactions; Binding and multiple hydrolytic sites in epitopes recognized by catalytic anti-peptide antibodies; Antibody catalysis of carbon-carbon bond formation; Characterization of the mechanism of action of a catalytic antibody; Catalytic antibodies: a new window on protein chemistry; Expanded transition state analogues; Tritylase antibodies; Final general discussion : How good are catalytic antibodies? 327 $aPotential uses of catalytic antibodiesSummary; Index of contributors; Subject index 330 $aContains the presentations and discussions that took place during a symposium at the CIBA Foundation on October 1-3, 1990 on the subject of catalytic antibodies. The recognition that monoclonal antibodies can possess catalytic activity is a recent advance with profound ramifications for chemistry. In addition to their potential commercial applications as catalysts for reactions, for which there are no known enzymes, antibodies promise to provide valuable insight into the detailed mechanisms of biological catalysis and organic chemistry. 410 0$aCiba Foundation symposium ;$v159. 606 $aMonoclonal antibodies 606 $aEnzymes 608 $aElectronic books. 615 0$aMonoclonal antibodies. 615 0$aEnzymes. 676 $a591.2 676 $a591.293 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144297403321 996 $aCatalytic antibodies$92041680 997 $aUNINA