LEADER 02706nam 2200541 450 001 9910511470503321 005 20180709164006.0 010 $a1-78330-156-2 035 $a(CKB)3710000001362979 035 $a(MiAaPQ)EBC4863288 035 $a(UkCbUP)CR9781783301577 035 $a(PPN)232566585 035 $a(EXLCZ)993710000001362979 100 $a20170616h20172017 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 14$aThe silence of the archive /$fDavid Thomas, Simon Fowler and Valerie Johnson 210 1$aLondon :$cFacet,$d2017. 215 $a1 online resource (190 pages) 225 0 $aPrinciples and Practice in Records Management and Archives Series 300 $aTitle from publisher's bibliographic system (viewed on 05 Jul 2018). 311 $a1-78330-155-4 311 $a1-78330-157-0 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aEnforced silences / Simon Fowler -- Inappropriate expectations / Simon Fowler -- The digital / David Thomas -- Dealing with the silence / Valerie Johnson -- Imagining archives / David Thomas -- Solutions to the silence / Valerie Johnson -- Are things getting better or worse? / David Thomas. 330 $aThis new book will provide a ground breaking discussion of a major but little considered issue - the silence of the archive: why archives, sometimes seen as the repositories of truth, often fail to satisfy users because they do not contain information which they expect to find. Silences range from details of individuals' lives to records of state oppression or of intelligence operations. The book brings together ideas from a wide range of fields, from contemporary history through family history research to Shakespearian studies. It describes why there are these silences, what the impact of them is, how researchers have responded to them and what the silence of the archive means for researchers in the digital age. 410 0$aPrinciples and practice in records management and archives. 606 $aAppraisal of archival materials 606 $aArchives$xAcquisitions 606 $aRecords retention 608 $aElectronic books. 615 0$aAppraisal of archival materials. 615 0$aArchives$xAcquisitions. 615 0$aRecords retention. 676 $a025.21 700 $aThomas$b David$0382009 702 $aFowler$b Simon 702 $aJohnson$b Valerie 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910511470503321 996 $aThe silence of the archive$92551652 997 $aUNINA LEADER 05226nam 2200625Ia 450 001 9910144278503321 005 20170810191455.0 010 $a1-281-31181-2 010 $a9786611311810 010 $a3-527-62107-5 010 $a3-527-62108-3 035 $a(CKB)1000000000376633 035 $a(EBL)481826 035 $a(OCoLC)609855462 035 $a(SSID)ssj0000303420 035 $a(PQKBManifestationID)11232740 035 $a(PQKBTitleCode)TC0000303420 035 $a(PQKBWorkID)10275875 035 $a(PQKB)10576274 035 $a(MiAaPQ)EBC481826 035 $a(PPN)242930727 035 $a(EXLCZ)991000000000376633 100 $a20070618d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aModern alkaloids$b[electronic resource] $estructure, isolation, synthesis and biology /$fedited by Ernesto Fattorusso and Orazio Taglialatela-Scafati 210 $aWeinheim $cWiley-VCH$dc2008 215 $a1 online resource (691 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31521-7 320 $aIncludes bibliographical references and index. 327 $aModern Alkaloids; Contents; Preface; List of Contributors; I Bioactive Alkaloids: Structure and Biology; 1 Ecological Roles of Alkaloids; 1.1 Introduction: Defense Strategies in Plants; 1.2 Ecological Roles of Alkaloids; 1.3 Modes of Action; 1.3.1 Unspecific Interactions; 1.3.2 Specific Interactions; 1.3.3 Cytotoxicity of Alkaloids; 1.4 Evolution of Alkaloidal Defense Systems; 1.5 Conclusions; 2 Antitumor Alkaloids in Clinical Use or in Clinical Trials; 2.1 Introduction; 2.2 Antitumor Alkaloids in Clinical Use; 2.2.1 Vinca Alkaloids; 2.2.1.1 Vinblastine (VLB, 1); 2.2.1.2 Vincristine (VCR, 2) 327 $a2.2.1.3 Vindesine (VDS, 3)2.2.1.4 Vinorelbine (VRLB, 4); 2.2.1.5 Vinflunine (VFL, 5); 2.2.2 Camptothecin and Analogs; 2.2.2.1 Camptothecin (CPT, 6); 2.2.2.2 Irinotecan (CPT-11); 2.2.2.3 Topotecan; 2.2.2.4 Exatecan; 2.2.2.5 Gimatecan; 2.2.2.6 Karenitecin; 2.2.2.7 Lurtotecan; 2.2.2.8 Rubitecan (9-nitrocamptothecin); 2.2.3 Taxanes; 2.2.3.1 Paclitaxel; 2.2.3.2 Docetaxel; 2.3 Antitumor Alkaloids in Clinical Trials; 2.3.1 Ecteinascidin-743 (Yondelis, Trabectedin); 2.3.2 7-Hydroxystaurosporine (UCN-01); 2.3.3 Ellipticine and Analogs; 2.3.4 Acronycine and Analogs; 2.3.5 Colchicine and Analogs 327 $a2.3.6 Ukrain2.4 Alkaloids Used for MDR Reversal; 2.4.1 Cinchona Alkaloids; 2.4.2 Dofequidar Fumarate (MS-209); 2.5 Alkaloids Used for Cancer Prevention; 2.6 Conclusions; 2.7 Acknowledgments; 3 Alkaloids and the Bitter Taste; 3.1 Introduction; 3.2 The Bitter Taste Chemoreception Mechanism; 3.3 Bitter Alkaloids in Food; 3.4 The Bitter Taste of Alkaloids in Other Drugs and Poisons; 3.5 Alkaloids and Taste in Insects; 3.6 The Bitter Taste of Alkaloids: Should We Avoid, Mask, or Understand?; 3.7 Acknowledgments; 4 Capsaicin and Capsaicinoids; 4.1 Introduction 327 $a4.2 What Is an Alkaloid? Is Capsaicin an Alkaloid?4.3 Diversity, Biosynthesis, and Metabolism of Capsaicinoids; 4.4 Quantization of Capsaicinoids and Their Distribution in Chili Pepper; 4.5 Isolation and Synthesis of Capsaicin; 4.6 TRV1 as the Biological Target of Capsaicin and the Ecological Raison d'e?tre of Capsaicinoids: A Molecular View; 4.7 Naturally Occurring Analogs and Antagonists of Capsaicin and Endogenous Vanilloids; 4.8 Structure-Activity Relationships of Capsaicinoids; 4.9 Molecular Gastronomy of Hot Food; 4.9.1 Biomedical Relevance of Capsaicin-Induced Trigeminal Responses 327 $a4.9.2 Effect of Capsaicin on Taste4.9.3 Gustatory Sweating; 4.9.4 Gustatory Rhinitis; 4.9.5 Hot Food Mitridatism; 4.9.6 Effect of Capsaicin on Digestion; 4.9.7 Capsaicin and Stomach Cancer; 4.9.8 The Effect of Age and Sex on the Sensitivity to Capsaicin; 4.9.9 Capsaicin as a Slimming Agent; 4.9.10 Quenching Capsaicin; 4.9.11 Chilies and Olive Oil; 4.9.12 Who Should Avoid Chilies?; 4.9.13 How can the Pungency of Chilies be Moderated?; 4.9.14 Psychology of Pepper Consumption; 4.10 Conclusions; 4.11 Acknowledgments; 5 Glycosidase-Inhibiting Alkaloids: Isolation, Structure, and Application 327 $a5.1 Introduction 330 $aThis book presents all important aspects of modern alkaloid chemistry, making it the only work of its kind to offer up-to-date and comprehensive coverage. While the first part concentrates on the structure and biology of bioactive alkaloids, the second one analyzes new trends in alkaloid isolation and structure elucidation, as well as in alkaloid synthesis and biosynthesis.A must for biochemists, organic, natural products, and medicinal chemists, as well as pharmacologists, pharmaceutists, and those working in the pharmaceutical industry. 606 $aAlkaloids$xStructure 606 $aAlkaloids 615 0$aAlkaloids$xStructure. 615 0$aAlkaloids. 676 $a572.549 701 $aFattorusso$b Ernesto$0100689 701 $aTaglialatela-Scafati$b Orazio$091837 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144278503321 996 $aModern alkaloids$91933179 997 $aUNINA