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010   $a9786610519491
010   $a3-527-60394-8
010   $a3-527-60402-2
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100   $a20060807d2004      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aChemogenomics in drug discovery$b[electronic resource] $ea medicinal chemistry perspective /$fedited by Hugo Kubinyi and Gerhard Mu?ller
210   $aWeinheim $cWiley-VCH$dc2004
215   $a1 online resource (489 p.)
225 1 $aMethods and principles in medicinal chemistry ;$vv. 22
300   $aDescription based upon print version of record.
311   $a3-527-30987-X 
320   $aIncludes bibliographical references and index.
327   $tTarget family-directed masterkeyes in chemogenomics /$rGehard Mu?ller --$tDrug discovery from side effects /$rHugo Kubinyi --$tThe value of chemical genetics in drug discovery /$rKeith Russell and William F. Michne --$tStructural aspects of binding site similarity: a 3D upgrade for chemogenomics /$rAndreas Bergner and Judith Gu?nther --$tThe contribution of molecular informatics to chemogenomics: knowledge-based discovery of biological targets and chemical lead compounds /$rEdgar Jacoby, Ansgar Schuffenhauer, and Pierre Acklin --$tChemical kinomics /$rBert M. Klebl, Henrik Daub, and Gyo?rgy Ke?ri --$tStructural aspects of kinases and their inhibitors /$rRogier Buijsman --$tA chemical genomics approach for ion channel modulators /$rKarl-Heinz Baringhaus and Gerhard Hessler --$tPhosphodiesterase inhibitors: a chemogenomic view /$rMartin Hendrix and Christopher Kallus --$tProteochemometrics: a tool for modeling the molecular interaction space /$rJarl E.S. Wikberg, Maris Lapinsch, and Peteris Prusis --$tSome principles related to chemogenomics in compound library and template design for GPCRs /$rThomas R. Webb --$tComputational filters in lead generation: targeting drug-like chemotypes /$rWolfgang Guba and Olivier Roche --$tNavigation in chemical space: ligand-based design of focused compound libraries /$rGisbert Schneider and Petra Schneider --$tNatural product-derived compound libraries and protein structure similarity as guiding principles for the discovery of drug candidates /$rMarcus A. Koch and Herbert Waldmann --$tCombinatorial chemistry in the age of chemical genomics /$rReni Joseph and Prabhat Arya.
330   $aChemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.
410  0$aMethods and principles in medicinal chemistry ;$vv. 22.
606   $aPharmaceutical chemistry
606   $aDrug development
606   $aMe?dicaments$xDe?veloppement
606   $aChimie pharmaceutique
606   $aMe?dicaments$xRecherche
606   $aMe?dicaments$xConception
608   $aElectronic books.
615  0$aPharmaceutical chemistry.
615  0$aDrug development.
615  6$aMe?dicaments$xDe?veloppement.
615  6$aChimie pharmaceutique.
615  6$aMe?dicaments$xRecherche.
615  6$aMe?dicaments$xConception.
676   $a615.19
701   $aKubinyi$b Hugo$096070
701   $aMu?ller$b Gerhard$f1963-$0997915
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910144276003321
996   $aChemogenomics in drug discovery$92288668
997   $aUNINA