LEADER 05427nam 2200673 450 001 9910144229803321 005 20170809175215.0 010 $a1-281-94689-3 010 $a9786611946890 010 $a3-527-62248-9 010 $a3-527-62249-7 035 $a(CKB)1000000000554041 035 $a(EBL)481324 035 $a(OCoLC)277155574 035 $a(SSID)ssj0000106997 035 $a(PQKBManifestationID)11122402 035 $a(PQKBTitleCode)TC0000106997 035 $a(PQKBWorkID)10009011 035 $a(PQKB)11591459 035 $a(MiAaPQ)EBC481324 035 $a(EXLCZ)991000000000554041 100 $a20160819h20082008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAsymmetric organic synthesis with enzymes /$fedited by Vicente Gotor, Ignacio Alfonso, and Eduardo Garci?a-Urdiales 210 1$aWeinheim, Germany :$cWILEY-VCH Verlag GmbH & Co. KGaA,$d2008. 210 4$d©2008 215 $a1 online resource (341 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31825-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aAsymmetric Organic Synthesis with Enzymes; Contents; Preface; List of Contributors; I Methodology; 1 Medium Engineering; 1.1 Introduction; 1.2 Modulation of Enzyme Enantioselectivity by Medium Engineering; 1.2.1 Selectivity Enhancement by Addition of Water-Miscible Organic Cosolvents; 1.2.2 Selectivity Enhancement in Organic Media with Low Water Activity; 1.2.2.1 Organic Solvent Systems; 1.2.2.2 Enzyme Properties in Organic Solvents; 1.2.2.3 Medium Engineering; 1.2.3 Rationales; 1.2.4 Modulation of Enzyme Selectivity: New Trends of Research; 1.2.4.1 Ionic Liquids; 1.2.4.2 Additives 327 $a1.3 Conclusions and OutlooksReferences; 2 Directed Evolution as a Means to Engineer Enantioselective Enzymes; 2.1 Introduction; 2.2 Molecular Biological Methods for Mutagenesis; 2.3 High-throughput Screening Methods for Enantioselectivity; 2.4 Examples of Enhancing the Enantioselectivity of Enzymes by Directed Evolution; 2.4.1 Lipase from Pseudomonas aeruginosa (PAL); 2.4.2 Other Lipases; 2.4.3 Esterases; 2.4.4 Hydantoinases; 2.4.5 Nitrilases; 2.4.6 Epoxide Hydrolases; 2.4.7 Phosphotriesterases; 2.4.8 Aminotransferases; 2.4.9 Aldolases 327 $a2.4.10 Cyclohexanone and Cyclopentanone Monooxygenases as Baeyer-Villigerases and Sulfoxidation Catalysts2.4.11 Monoamine Oxidases; 2.4.12 Cytochrome P450 Enzymes; 2.4.13 Other Enzymes; 2.5 Conclusions and Perspectives; References; 3 The Search for New Enzymes; 3.1 Introduction; 3.2 Mechanism-based Enzyme Design; 3.2.1 Catalytic Antibodies; 3.2.2 Rational Design of New Catalysts on Enzyme and Protein Basis; 3.2.3 Synthetic Enzyme Models; 3.3 Metagenomics; 3.3.1 Construction of Metagenome-derived DNA Libraries; 3.3.1.1 Selection of the Environment; 3.3.1.2 Cloning Strategies 327 $a3.3.1.3 Screening and Detection Technologies3.3.1.4 Major Problems that Need to be Addressed; 3.3.2 The Genomes of Not Yet Cultured Microbes as Resources for Novel Genes; 3.3.2.1 Polysaccharide Degrading/Modifying Enzymes; 3.3.2.2 Lipolytic Biocatalysts; 3.3.2.3 Vitamin Biosynthesis; 3.3.2.4 Nitrilases, Nitrile Hydratases, and Amidases; 3.3.2.5 Oxidoreductases/Dehydrogenases; 3.3.2.6 Proteases; 3.3.2.7 Glycerol Hydratases; 3.3.2.8 Antibiotics and Pharmaceuticals; 3.4 Conclusion; References; II Synthetic Applications; 4 Dynamic Kinetic Resolutions; 4.1 Introduction 327 $a4.1.1 Synthesis of Enantiomerically Pure Compounds4.1.2 Kinetic Resolution (KR) and Dynamic Kinetic Resolution (DKR); 4.1.3 Enzymes in Organic Chemistry; 4.2 Metal-Catalyzed Racemization; 4.2.1 DKR of Allylic Acetates and Allylic Alcohols; 4.2.2 DKR of sec-alcohols; 4.2.3 DKR of Amines; 4.3 Base-Catalyzed Racemization; 4.3.1 DKR of Thioesters; 4.3.2 DKR of Activated Esters; 4.3.3 DKR of Oxazolones; 4.3.4 DKR of Hydantoins; 4.3.5 DKR of Acyloins; 4.4 Acid-Catalyzed Racemization; 4.5 Racemization through Continuous Reversible Formation-Cleavage of the Substrate; 4.5.1 DKR of Cyanohydrins 327 $a4.5.2 DKR of Hemithioathetals 330 $aPerfect for biochemists, synthetic and organic chemists, this book covers all important reactions, including C-C coupling reactions, oxidation reactions and many more. Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer-aided prediction of enantioselectivity. The second and main section deals with applications to synthesis, showing important reaction types and their applications. Only those reactions with very high selectivity are prese 606 $aEnzymes$xSynthesis 606 $aAsymmetric synthesis 606 $aOrganic compounds$xSynthesis 608 $aElectronic books. 615 0$aEnzymes$xSynthesis. 615 0$aAsymmetric synthesis. 615 0$aOrganic compounds$xSynthesis. 676 $a572.745 702 $aGotor$b Vicente 702 $aAlfonso$b Ignacio 702 $aGarci?a-Urdiales$b Eduardo 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144229803321 996 $aAsymmetric organic synthesis with enzymes$92238511 997 $aUNINA LEADER 03404nam 2200601 450 001 9910816809203321 005 20200903223051.0 010 $a90-04-26176-1 024 7 $a10.1163/9789004261761 035 $a(CKB)3710000000078112 035 $a(EBL)1580000 035 $a(SSID)ssj0001081883 035 $a(PQKBManifestationID)11667891 035 $a(PQKBTitleCode)TC0001081883 035 $a(PQKBWorkID)11096919 035 $a(PQKB)10665338 035 $a(MiAaPQ)EBC1580000 035 $a(nllekb)BRILL9789004261761 035 $a(Au-PeEL)EBL1580000 035 $a(CaPaEBR)ebr10819083 035 $a(CaONFJC)MIL551311 035 $a(OCoLC)865656765 035 $a(PPN)178907510 035 $a(EXLCZ)993710000000078112 100 $a20140103d2014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aHenricus Glareanus's (1488-1563) chronologia of the ancient world $ea facsimile edition of a heavily annotated copy held in Princeton University Library /$fintroduction and transcription by Anthony T. Grafton, Urs B. Leu 210 1$aLeiden, Netherlands :$cBrill,$d2014. 210 4$d©2014 215 $a1 online resource (177 p.) 225 1 $aStudies in Medieval and Reformation Traditions,$x1573-4188 ;$vVolume 177 300 $aDescription based upon print version of record. 311 $a90-04-26175-3 327 $tFront Matter /$rAnthony T. Grafton and Urs B. Leu -- $tGlareanus?s Chronologia /$rAnthony T. Grafton and Urs B. Leu -- $tFacsimile and Transcription of Hummelberg?s Annotations /$rAnthony T. Grafton and Urs B. Leu. 330 $aThe humanists of the fifteenth and sixteenth centuries took a passionate interest in Livy?s History of Rome . No one studied the text more intensively than the Swiss scholar Henricus Glareanus, who not only held lectures on different Roman historians at the University of Freiburg im Breisgau, but also drew up chronological tables for ancient history, which were printed several times in Basle, sometimes together with Livy?s History . Glareanus annotated his personal copy of the chronological tables and invited his students to copy his marginal notes into their own copies of the book. Three of these copies survived, and give new insight into Glareanus?s practices as a scholar and teacher. The notes they contain?and the way in which Glareanus used them as a teacher?are distinctive, and neither has had much attention in the past from historians of reading. This volume presents facsimile reproductions of the tables from one of the surviving copies, now kept in Princeton University Library. The high-quality reproductions include transcriptions of the handwritten notes, unlocking Glareanus?s teachings for a new generation of students and researchers. 410 0$aStudies in medieval and Reformation traditions ;$vv. 177. 606 $aHistory, Ancient$vEarly works to 1800 615 0$aHistory, Ancient 676 $a930 700 $aGrafton$b Anthony$f1488-1563.$01667330 701 $aGrafton$b Anthony$0181216 701 $aLeu$b Urs B$g(Urs Bernhard),$f1961-$01631362 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910816809203321 996 $aHenricus Glareanus's (1488-1563) chronologia of the ancient world$94027083 997 $aUNINA LEADER 02834nam 2200505 450 001 9910817669703321 005 20220531075305.0 010 $a3-8467-5651-2 024 7 $a10.30965/9783846756515 035 $a(CKB)4920000000126240 035 $z(OCoLC)74270018 035 $a(nllekb)BRILL9783846756515 035 $a(MiAaPQ)EBC6516483 035 $a(Au-PeEL)EBL6516483 035 $a(OCoLC)1243533860 035 $a(Wilhelm Fink Verlag)9783846756515 035 $a(EXLCZ)994920000000126240 100 $a20220531d2006 uy 0 101 0 $ager 135 $aurun| uuuua 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $2rdacarrier 200 10$aArchitektur und Atmospha?re /$fGernot Bo?hme 205 $a2., korrigierte Auflage. 210 1$aMu?nchen :$cWilhelm Fink,$d[2006] 210 4$d©2006 215 $a1 online resource 300 $aBrill | Fink 311 $a3-7705-5651-8 327 $aPreliminary Material -- Vorwort -- Zur Einführung: Ästhetik der Atmosphären -- Leben mit Atmosphären -- Atmosphären im Bild -- Licht und Ton im Raum -- Atmosphären in der Architektur -- Kritische Perspektiven -- Danksagung -- Namensregister. 330 $aDas Buch konstatiert, dass mit und nach der Postmoderne etwas Grundsa?tzlicheres geschehen ist als nur eine Pluralisierung der Stile, ein Wiederzulassen des Ornamentes und des historischen Zitats. Der Autor spricht von einem Neuen Humanismus in der Architektur. Anders als bei Vitruv, bei dem der Mensch das Grundmaß fu?r die Architektur abgab und insofern dessen Geometrie bestimmte, sei der Mensch heute als Benutzer, als jemand, der sich in und in der Umgebung von Geba?uden in bestimmter Weise befindet, zum Bezugspunkt des Bauens geworden. Das eigentliche Thema der Architektur, behauptet Bo?hme, ist der Raum und zwar der gestimmte Raum, also die Atmospha?re. Das Buch fu?hrt umfassend in die A?sthetik der Atmospha?ren ein, studiert die Rolle nicht-materieller Elemente, wie Licht und Ton, in der Architektur, problematisiert die traditionelle Auffassung von Architektur als einer visual art, fu?hrt das Atmospha?renkonzept in Fallstudien durch (z.B. Stadtplanung und Kirchenbau) und widmet sich schließlich den kritischen Aspekten einer Architektur der Atmospha?ren: der mo?glichen politischen und o?konomischen Manipulation durch eine Architektur, die zum Bu?hnenbild gera?t. 606 $aArchitecture$xAesthetics 606 $aArchitecture and society 615 0$aArchitecture$xAesthetics. 615 0$aArchitecture and society. 676 $a720.1 700 $aBo?hme$b Gernot$0386480 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910817669703321 996 $aArchitektur und Atmosphare$91082888 997 $aUNINA