LEADER 05407nam 2200685Ia 450 001 9910144107803321 005 20230721033057.0 010 $a1-281-84122-6 010 $a9786611841225 010 $a0-470-98573-9 010 $a0-470-98572-0 035 $a(CKB)1000000000550229 035 $a(EBL)366789 035 $a(OCoLC)437234401 035 $a(SSID)ssj0000217141 035 $a(PQKBManifestationID)11197958 035 $a(PQKBTitleCode)TC0000217141 035 $a(PQKBWorkID)10198262 035 $a(PQKB)10479276 035 $a(MiAaPQ)EBC366789 035 $a(Au-PeEL)EBL366789 035 $a(CaPaEBR)ebr10257619 035 $a(CaONFJC)MIL184122 035 $a(EXLCZ)991000000000550229 100 $a20070810d2008 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aOvercoming steroid insensitivity in respiratory disease$b[electronic resource] /$fedited by Ian M. Adcock and Kian Fan Chung 210 $aChichester, England ;$aHoboken, NJ $cJ. Wiley$dc2008 215 $a1 online resource (310 p.) 300 $aDescription based upon print version of record. 311 $a0-470-05808-0 320 $aIncludes bibliographical references and index. 327 $aOvercoming Steroid Insensitivity in Respiratory Disease; Contents; List of Contributors; Preface; 1 Molecular Mechanisms of Glucocorticoid Receptor Action; 1.1 Introduction; 1.2 Glucocorticoid Receptor; 1.3 Gene Induction by GR; 1.4 GR Transactivation and Histone Acetylation; 1.5 Post-translational Modifications of GR; 1.6 Repression of NF-?B-induced Inflammatory GeneExpression by GR-NF-?B; 1.7 GR-NF-?B Cross-talk; 1.8 Role of HDAC2 in Glucocorticoid Function; 1.9 Overexpression of HDAC2 Restores Glucocorticoid Sensitivity in Alveolar Macrophages 327 $a1.10 Acetylation of hsp90 and Regulation of GR Function 1.11 Other Mechanisms of GR Action; 1.12 Conclusions; 2 Side Effects of Topical and Oral Glucocorticoids; 2.1 Introduction; 2.2 Glucocorticoid-induced Side Effects; 2.3 Summary; 3 Glucocorticoid Receptor Subtypes and Steroid Sensitivity; 3.1 Introduction; 3.2 Overview of Classic GR Function; 3.3 GR Subtypes Arising from Alternative Splicing; 3.4 GR Subtypes arising from Alternative Translation Initiation; 3.5 Conclusions; 4 Dissociated Glucocorticoids; 4.1 Introduction 327 $a4.2 Asthma and Chronic Obstructive Pulmonary Disease are Chronic Inflammatory Diseases of the Airways 4.3 Regulation of Inflammatory Gene Expression; 4.4 Effects on Inflammation; 4.5 Mechanisms of Glucocorticoid Action; 4.6 Dissociated Glucocorticoids; 4.7 GR Cross-talk with Other Nuclear Receptors and Coactivators; 4.8 Overcoming Steroid Insensitivity; 4.9 Glucorticoid-sparing Approaches to Anti-inflammatory Therapy; 4.10 Conclusion; 5 Generalized Glucocorticoid Insensitivity: Clinical Phenotype and Molecular Mechanisms; 5.1 Introduction; 5.2 Molecular Mechanisms of Glucocorticoid Resistance 327 $a5.3 Conclusions 6 Corticosteroid Responsiveness in Asthma: Clinical Aspects; 6.1 Introduction; 6.2 Effects of Corticosteroids in Asthma; 6.3 Definition of Corticosteroid Insensitivity; 6.4 Oral CS Responsiveness in Asthma; 6.5 ICS Responsiveness in Asthma; 6.6 CS Responsiveness in Severe Asthma; 6.7 Surrogates for CS Responsiveness in Asthma; 6.8 Pharmacokinetics of Systemic CS in Severe Asthma; 6.9 CS Responsiveness in Cigarette Smokers and Chronic Obstructive Pulmonary Disease; 6.10 Other Diseases of CS Insensitivity; 6.11 Conclusions 327 $a7 Glucocorticoid-insensitive Asthma: Molecular Mechanisms 7.1 Introduction; 7.2 GR Abnormalities; 7.3 GR Nuclear Translocation; 7.4 Cross-talk with Transcription Factors; 7.5 NF-?B, GR, Histones and Chromatin Remodelling; 7.6 Epigenetics and Asthma; 7.7 Conclusions; 8 Cigarette Smoke, Oxidative Stress and Corticosteroid Responsiveness; 8.1 Oxidative Stress; 8.2 Cigarette Smoke/Oxidative Stress-InducedNF-?B-mediated Pro-inflammatory Gene Expression; 8.3 Histone Acetylation and Deacetylation; 8.4 Corticosteroids; 8.5 Histone Deacetylases; 8.6 Reversing Glucocorticoids / Corticosteroid Resistance 327 $a8.7 Conclusion 330 $aWritten by well-known experts in field, this is the first book dedicated to dealing with the single most challenging management issue in long-term steroid therapy. Overcoming Steroid Insensitivity in Respiratory Disease reviews important new advances in therapeutics and provides the clinician with the most up to date information on one of the most significant therapeutic challenges to effective management of these diseases. This unique book is an invaluable resource for all postgraduate students and specialist physicians in pulmonology allergy and asthma. It is also of interest 606 $aRespiratory organs$xDiseases$xChemotherapy 606 $aSteroid drugs 606 $aDrug resistance 615 0$aRespiratory organs$xDiseases$xChemotherapy. 615 0$aSteroid drugs. 615 0$aDrug resistance. 676 $a616.2 676 $a616.200461 701 $aAdcock$b Ian$g(Ian M.)$0879010 701 $aChung$b K. Fan$f1951-$0879011 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144107803321 996 $aOvercoming steroid insensitivity in respiratory disease$91963012 997 $aUNINA