LEADER 03767nam  2200649 a 450 
001 9910144011703321
005 20190523223455.0
010   $a1-282-13793-X
010   $a9786612137938
010   $a0-470-51473-6
010   $a0-470-51474-4
035   $a(CKB)1000000000376020
035   $a(EBL)470700
035   $a(OCoLC)649839031
035   $a(SSID)ssj0000388235
035   $a(PQKBManifestationID)11278786
035   $a(PQKBTitleCode)TC0000388235
035   $a(PQKBWorkID)10411377
035   $a(PQKB)10102828
035   $a(MiAaPQ)EBC470700
035   $a(EXLCZ)991000000000376020
100   $a19941110d1995      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aSomatostatin and its receptors$b[electronic resource]
210   $aChichester ;$aNew York $cWiley$d1995
215   $a1 online resource (285 p.)
225 1 $aCiba Foundation symposium ;$v190
300   $aSymposium on Somatostatin and its receptors, held at the Ciba Foundation, London 12-14 July 1994.
300   $aEditors: Derek J. Chadwick (organizer) and Gail Cardew.
311   $a0-471-95382-2 
320   $aIncludes bibliographical references and indexes.
327   $aSOMATOSTATIN AND ITS RECEPTORS; Contents; Participants; Introduction; Regulation of somatostatin gene transcription by cAMP; Processing and intracellular targeting of prosomatostatin-derived peptides: the role of mammalian endoproteases; Anatomical localization and regulation of somatostatin gene expression in the basal ganglia and its clinical implications; Molecular biology of somatostatin receptors; Characterization of somatostatin receptor subtypes; Regulation of somatostatin receptor mRNA expression; Transient expression of somatostatin receptors in the brain during development
327   $aExpression of sstrl and sstr2 in rat hypothalamus: correlation with receptor binding and distribution of growth hormone regulatory peptidesInteraction of somatostatin receptors with G proteins and cellular effector systems; Somatostatin modulates voltage- dependent Ca2+ channels in GH3 cells via a specific Go splice variant; A tyrosine phosphatase is associated with the somatostatin receptor1; Function and regulation of somatostatin receptor subtypes; Somatostatin receptors: clinical implications for endocrinology and oncology
327   $aSomatostatin analogues and multiple receptors: possible physiological rolesFinal discussion; Summary; Appendix; Index of contributors; Subject index
330   $aThis book describes a diverse analysis of the five somatostatin receptors; somatostatin gene regulation; promatostatin processing; mechanisms of signal transduction; and the design and use of somatostatin analogues, including their possible clinical implications. The book will provide a comprehensive summary of the cellular and molecular biology of somatostatin and its recently isolated receptors. The book will review the design and use of specific somatostatin analogues both biochemically to characterize the specific functions of somatostatin and clinically in the treatment of various tumors.
410  0$aCiba Foundation symposium ;$v190.
606   $aSomatostatin$vCongresses
606   $aSomatostatin$xReceptors$vCongresses
608   $aElectronic books.
615  0$aSomatostatin
615  0$aSomatostatin$xReceptors
676   $a591.192456
676   $a612.4/05
676   $a612.405
701   $aChadwick$b Derek$091632
701   $aCardew$b Gail$0857118
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910144011703321
996   $aSomatostatin and its receptors$92026334
997   $aUNINA