LEADER 03940nam 2200637 a 450 001 9910144011403321 005 20211007205910.0 010 $a1-282-34805-1 010 $a9786612348051 010 $a0-470-51539-2 010 $a0-470-51540-6 035 $a(CKB)1000000000376023 035 $a(EBL)470448 035 $a(OCoLC)609849347 035 $a(SSID)ssj0000305014 035 $a(PQKBManifestationID)11259778 035 $a(PQKBTitleCode)TC0000305014 035 $a(PQKBWorkID)10285230 035 $a(PQKB)11605647 035 $a(MiAaPQ)EBC470448 035 $a(EXLCZ)991000000000376023 100 $a19970602d1997 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aOligonucleotides as therapeutic agents$b[electronic resource] /$f[editors, Derek J. Chadwick (Organizer) and Gail Cardew] 210 $aChichester ;$aNew York $cWiley$d1997 215 $a1 online resource (262 p.) 225 1 $aCiba Foundation symposium ;$v209 300 $aProceedings of the Symposium on Oligonucleotides as Therapeutic Agents, held at Ciba Foundation on 7-9 January 1997. 311 $a0-471-97279-7 320 $aIncludes bibliographical references and indexes. 327 $aOLIGONUCLEOTIDES AS THERAPEUTIC AGENTS; Contents; Participants; Introduction; Oligoncleotide analogues: an overview; Phosphorothioate oligodeox ynucleotides: large-scale synthesis and analysis, impurity characterization, and the effects of phosphorus stereochemistry; Discovering antisense reagents by hybridization of RNA to oligonucleotide arrays; Pharrnacokinetics of oligonucleotides in cell culture; Pharrnacokinetics of oligonucleotides; Controversies in the cellular pharmacology of oligodeox ynucleotides; Sequence-specific control of gene expression by antigene and clamp oligonucleotides 327 $aFirst- and second-generation antisense oligonucleotide inhibitors targeted against human c-raf kinaseDifferential oligonucleotide activity in cell culture versus mouse models; Structure-activity relationships in cell culture; Progress in antisense therapeutics discovery and development; Oligonucleotide therapeutics for human leukemia; Therapeutic applications of catalytic antisense RNAs (ribozymes); Exogenous application of riboaymes for inhibiting gene expression; Efficient process technologies for the preparation of oligonucleotides 327 $aIn vivo production of oligodeoxyribonucleotides of specific sequences: application to antisense DNASummary; Index of contributors; Subject index 330 $aThe use of oligonucleotides as therapeutic agents rests upon their ability to interfere, in a sequence-specific manner, with the fundamental machinery of protein synthesis either by binding to the mRNAs transcribed from a gene or by binding directly to a target gene. This approach can be used not only for inhibition of the synthesis of host proteins but also of those required by invading pathogens. Potential therapeutic applications are enormous, ranging over hypertension, cardiovascular disease, autoimmune disease, vital and other parasitic infections (especially HIV), and cancer. This book d 410 0$aCiba Foundation symposium ;$v209. 606 $aOligonucleotides$xTherapeutic use$vCongresses 606 $aAntisense nucleic acids$xTherapeutic use$vCongresses 608 $aElectronic books. 615 0$aOligonucleotides$xTherapeutic use 615 0$aAntisense nucleic acids$xTherapeutic use 676 $a615 676 $a615.31 701 $aChadwick$b Derek$091632 701 $aCardew$b Gail$0857118 712 12$aSymposium on Oligonucleotides as Therapeutic Agents$f(1997 :$eCiba Foundation) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144011403321 996 $aOligonucleotides as therapeutic agents$92013976 997 $aUNINA LEADER 04858nam 2200721Ia 450 001 9910782461903321 005 20200520144314.0 010 $a1-281-96683-5 010 $a9786611966836 010 $a0-226-90106-8 024 7 $a10.7208/9780226901060 035 $a(CKB)1000000000578445 035 $a(EBL)432314 035 $a(OCoLC)309871323 035 $a(SSID)ssj0000301917 035 $a(PQKBManifestationID)12132180 035 $a(PQKBTitleCode)TC0000301917 035 $a(PQKBWorkID)10266037 035 $a(PQKB)10029405 035 $a(SSID)ssj0000193623 035 $a(PQKBManifestationID)11182904 035 $a(PQKBTitleCode)TC0000193623 035 $a(PQKBWorkID)10219889 035 $a(PQKB)11121414 035 $a(MiAaPQ)EBC432314 035 $a(DE-B1597)523580 035 $a(OCoLC)1135615386 035 $a(DE-B1597)9780226901060 035 $a(Au-PeEL)EBL432314 035 $a(CaPaEBR)ebr10266041 035 $a(CaONFJC)MIL196683 035 $a(EXLCZ)991000000000578445 100 $a20041013d2005 uy 0 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aLiving with polio$b[electronic resource] $ethe epidemic and its survivors /$fDaniel J. Wilson 210 $aChicago $cUniversity of Chicago Press$dc2005 215 $a1 online resource (313 p.) 300 $aDescription based upon print version of record. 311 $a0-226-90104-1 311 $a0-226-90103-3 320 $aIncludes bibliographical references and index. 327 $tFront matter --$tContents --$tAcknowledgments --$t1. Introduction --$t2. "I'm Afraid It's Polio" --$t3. The Crisis of Acute Poliomyelitis --$t4. Covenants of Work: Recovery and the Rehabilitation Hospital --$t5. Straws on the Ceiling: Life on the Polio Wards --$t6. Going Home to a Long Recovery --$t7. Resuming Life after Polio --$t8. Living with Polio --$t9. An Old Foe Returns: Post-Polio Syndrome --$t10. Epilogue --$tNotes --$tIndex 330 $aPolio was the most dreaded childhood disease of twentieth-century America. Every summer during the 1940's and 1950's, parents were terrorized by the thought that polio might cripple their children. They warned their children not to drink from public fountains, to avoid swimming pools, and to stay away from movie theaters and other crowded places. Whenever and wherever polio struck, hospitals filled with victims of the virus. Many experienced only temporary paralysis, but others faced a lifetime of disability. Living with Polio is the first book to focus primarily on the personal stories of the men and women who had acute polio and lived with its crippling consequences. Writing from personal experience, polio survivor Daniel J. Wilson shapes this impassioned book with the testimonials of more than one hundred polio victims, focusing on the years between 1930 and 1960. He traces the entire life experience of the survivors-from the alarming diagnosis all the way to the recent development of post-polio syndrome, a condition in which the symptoms of the disease may return two or three decades after they originally surfaced. Living with Polio follows every physical and emotional stage of the disease: the loneliness of long separations from family and friends suffered by hospitalized victims; the rehabilitation facilities where survivors spent a full year or more painfully trying to regain the use of their paralyzed muscles; and then the return home, where they were faced with readjusting to school or work with the aid of braces, crutches, or wheelchairs while their families faced the difficult responsibilities of caring for and supporting a child or spouse with a disability. Poignant and gripping, Living with Polio is a compelling history of the enduring physical and psychological experience of polio straight from the rarely heard voices of its survivors. 606 $aPoliomyelitis$vPopular works 606 $aPostpoliomyelitis syndrome$vPopular works 610 $apolio, epidemic, sickness, disease, illness, medical, medicine, poliomyelitis, infectious, poliovirus, central nervous system, muscle weakness, paralysis, history, historical, 20th century, united states of america, american society, children, childhood, crippling, disability, personal stories, testimonials, diagnosis, post-polio syndrome, hospitalization, hospitals, treatment, braces, crutches, postpoliomyelitis, recovery, rehabilitation. 615 0$aPoliomyelitis 615 0$aPostpoliomyelitis syndrome 676 $a362.19691800973 676 $a616.8/35 676 $a616.835 700 $aWilson$b Daniel J.$f1949-$0775130 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910782461903321 996 $aLiving with polio$93675421 997 $aUNINA