LEADER 05413nam 2200661 450 001 9910144010303321 005 20230422044849.0 010 $a1-282-01043-3 010 $a9786612010439 010 $a3-527-61362-5 010 $a3-527-61363-3 035 $a(CKB)1000000000376030 035 $a(EBL)481613 035 $a(OCoLC)310351556 035 $a(SSID)ssj0000229427 035 $a(PQKBManifestationID)11190709 035 $a(PQKBTitleCode)TC0000229427 035 $a(PQKBWorkID)10171701 035 $a(PQKB)11386426 035 $a(MiAaPQ)EBC481613 035 $a(EXLCZ)991000000000376030 100 $a20160816h19991999 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aProstaglandins, leukotrienes, and other eicosanoids $efrom biogenesis to clinical application /$fF. Marks, G. Fu?rstenberger (eds.) 210 1$aWeinheim, [Germany] :$cWiley-VCH,$d1999. 210 4$dİ1999 215 $a1 online resource (410 p.) 300 $aDescription based upon print version of record. 311 $a3-527-29360-4 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aProstaglandins, Leukotrienes and Other Eicosanoids; Contents; 1 Arachidonic acid and companions: an abundant source of biological signals; 1.1 The world of PUFAs; 1.2 The discovery of prostaglandins and related eicosanoids; 1.3 Mammalian eicosanoids; 1.3.1 Free arachidonic acid: a signaling compound?; 1.3.2 Prostanoids; 1.3.3 HPETEs, HETEs and leukotrienes; 1.3.4 Lipoxins; 1.3.5 15-Epi-lipoxins; 1.3.6 Hepoxilins; 1.3.7 Monooxygenase-derived eicosanoids; 1.3.8 Isoprostanes; 1.3.9 Anandammide; 1.4 Eicosanoids in invertebrates; 1.5 Eicosanoid-related signaling compounds in plants 327 $a1.6 The cellular functions of eicosanoids in mammals1.6.1 Eicosanoids as local mediators; 1.6.2 Specific membrane receptors mediate many biological effects of eicosanoids; 1.6.3 Nuclear eicosanoid receptors: a new frontier in research; 1.7 Addendum: Methods of eicosanoid research; 1.8 References; 2 The generation of free arachidonic acid; 2.1 Introduction; 2.2 (Re)Incorporartion of arachidonic acid into phospholipids; 2.3 Phospholipases A; 2.3.1 Phospholipase A1; 2.3.2 Phospholipases A2; 2.3.2.1 Secretory phospholipases A2; 2.3.2.2 Cytosolic phospholipase A2 327 $a2.3.2.3 Calciurn-independent phospholipases A22.4 DAG lipase and PLC or PLD/PA phosphohydrolase; 2.5 Cellular models; 2.5.1 P388D1 macrophages; 2.5.2 Rat liver macrophages; 2.6 Conclusions; 2.7 References; 3 Cyclooxygenases; 3.1 Introduction; 3.2 Cloning of cyclooxygenase isoforms; 3.3 Cyclooxygenase gene structures; 3.4 Regulation of cyclooxygenase isoenzyme expression; 3.5 Cyclooxygenase proteins; 3.5.1 Sequence comparisons; 3.5.2 Post-translational modification; 3.5.3 X-ray analysis of crystal structure; 3.5.4 Subcellular localization; 3.6 Coupling of COX isoenzymes with phospholipases A2 327 $a3.7 Substrate specificities3.8 Mechanism of enzyme catalysis; 3.9 Biological functions of COX isoforms; 3.10 Isoenzyme-specific inhibitors; 3.11 References; 4 Prostanoid synthases; 4.1 Introduction; 4.2. Thromboxane A2 synthase; 4.3 Prostacyclin synthase; 4.4 Prostaglandin D syntase; 4.5. Prostaglandin E synthase; 4.6 Prostaglandin F synthase; 4.7 Glutathione S-transferases; 4.8 Detection of prostaglandin synthases in various tissues; 4.9 Summary and outlook; 4.10 References; 5 Lipoxygenases; 5.1. lntroduction; 5.2. Lipoxygenase reaction; 5.3. Common properties of lipoxygenases 327 $a5.4. Classification of lipoxygenases5.5 Structural aspects of lipoxygenases; 5.5.1. X-ray crystallography; 5.5.2 Substrate alignment and determinants of positional specificity; 5.6 5-Lipoxygenases; 5.6.1 Enzymatic properties; 5.6.2 5-Lipoxygenase activating protein; 5.6.3 Molecular biology of 5-lipoxygenases; 5.6.4 Tissue distribution and regulation of 5-LOX expression; 5.6.5 Biological functions of 5-lipoxygenases; 5.7 12-Lipoxygenases; 5.7.1 Subclassification and enzymatic properties; 5.7.2 Molecular biology of 12-lipoxygenases; 5.7.3 Tissue distribution and regulation of 12-LOX expression 327 $a5.7.4 Biological functions of 12-lipoxygenases 330 $aPolyunsaturated fatty acids are essential for human cell metabolism. As precursors of a very large and extremely versatile family of signaling compounds they play a key role in intracellular communication. Eicosanoids constitute one of the most abundant and prominent subfamilies of these fatty acid derivatives which are formed primarily along oxidative pathways. Prostaglandins, leukotrienes, and related eicosanoids have a modulatory function in mammalian cells and are responsible for tissue responses such as inflammation or wound repair. Increasing activity in eicosanoid research sheds new lig 606 $aEicosanoids 606 $aLeukotrienes 606 $aProstanoids 615 0$aEicosanoids. 615 0$aLeukotrienes. 615 0$aProstanoids. 676 $a572.57 676 $a572/.57 702 $aMarks$b Friedrich$f1936- 702 $aFu?rstenberger$b G$g(Gerhard), 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144010303321 996 $aProstaglandins, leukotrienes, and other eicosanoids$92054451 997 $aUNINA