LEADER 04870nam 2200637Ia 450 001 9910144008403321 005 20180718141707.0 010 $a1-281-31182-0 010 $a9786611311827 010 $a3-527-62109-1 010 $a3-527-62110-5 035 $a(CKB)1000000000376039 035 $a(EBL)482258 035 $a(OCoLC)609855569 035 $a(SSID)ssj0000303528 035 $a(PQKBManifestationID)11229478 035 $a(PQKBTitleCode)TC0000303528 035 $a(PQKBWorkID)10276336 035 $a(PQKB)11396046 035 $a(MiAaPQ)EBC482258 035 $a(EXLCZ)991000000000376039 100 $a20071001d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aMolecular system bioenergetics$b[electronic resource] $eenergy for life /$fedited by Valdur Saks 210 $aWeinheim $cWiley-VCH$dc2007 215 $a1 online resource (635 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31787-2 320 $aIncludes bibliographical references and index. 327 $aMolecular System Bioenergetics; Contents; Preface; List of Contributors; Introduction: From the Discovery of Biological Oxidation to Molecular System Bioenergetics; References; Part I Molecular System Bioenergetics: Basic Principles, Organization, and Dynamics of Cellular Energetics; 1 Cellular Energy Metabolism and Integrated Oxidative Phosphorylation; Abstract; 1.1 Introduction; 1.2 Membrane Transport and Initial Activation; 1.3 Cytosolic Pathway; 1.4 Mitochondrial Transport and Metabolism; 1.5 Respiratory Chain and Oxidative Phosphorylation; 1.6 Electron Supply 327 $a1.7 Reducing Power Shuttling Across the Mitochondrial Membrane1.8 Electron Transfer in the Respiratory Chain: Prominent Role of Complex I in the Regulation of the Nature of Substrate; 1.9 Modulation of Oxidative Phosphorylation by Respiratory Chain Slipping and Proton Leak; 1.10 The Nature of Cellular Substrates Interferes with the Metabolic Consequences of Uncoupling; 1.11 Dynamic Supramolecular Arrangement of Respiratory Chain and Regulation of Oxidative Phosphorylation; References; 2 Organization and Regulation of Mitochondrial Oxidative Phosphorylation; Abstract; 2.1 Introduction 327 $a2.2 Oxidative Phosphorylation and the Chemiosmotic Theory2.3 The Various Mechanisms of Energy Waste; 2.3.1 Passive Leak; 2.3.2 Leak Catalyzed by Uncoupling Proteins; 2.3.3 The Active Leak; 2.3.4 The Slipping Mechanism; 2.4 Mechanisms of Coupling in Proton Pumps; 2.5 Oxidative Phosphorylation Control and Regulation; 2.5.1 Metabolic Control Analysis; 2.5.2 Regulations; 2.5.2.1 Kinetic Regulation of Mitochondrial Oxidative Phosphorylation: Complex I Covalent cAMP-dependent Phosphorylation; 2.5.2.2 Cytochrome Oxidase: An Example of Coordinate Regulation 327 $a2.6 Supramolecular Organization of the Respiratory Chain2.6.1 Structural Data; 2.6.1.1 ATP Synthase Organization; 2.6.1.2 Respiratory Chain Supramolecular Organization; 2.6.2 Functional Data; 2.7 Conclusions; References; 3 Integrated and Organized Cellular Energetic Systems: Theories of Cell Energetics, Compartmentation, and Metabolic Channeling; Abstract; 3.1 Introduction; 3.2 Theoretical Basis of Cellular Metabolism and Bioenergetics; 3.2.1 Thermodynamic Laws, Energy Metabolism, and Cellular Organization 327 $a3.2.2 Chemical and Electrochemical Potentials: Energy of Transmembrane Transport and Metabolic Reactions3.2.3 Non-equilibrium, Steady-state Conditions; 3.2.4 Free Energy Changes and the Problem of Intracellular Organization of Metabolism; 3.2.5 Macromolecular Crowding, Heterogeneity of Diffusion, Compartmentation, and Vectorial Metabolism; 3.2.5.1 Heterogeneity of Intracellular Diffusion and Metabolic Channeling; 3.2.5.2 Compartmentation Phenomenon and Vectorial Metabolism; 3.3 Compartmentalized Energy Transfer and Metabolic Sensing 327 $a3.3.1 Compartmentation of Adenine Nucleotides in Cardiac Cells 330 $aIn this first integrated view, practically each of the world's leading experts has contributed to this one and only authoritative resource on the topic. Bringing systems biology to cellular energetics, they address in detail such novel concepts as metabolite channeling and medical aspects of metabolic syndrome and cancer. 606 $aBioenergetics 606 $aCell metabolism 606 $aEnergy metabolism 608 $aElectronic books. 615 0$aBioenergetics. 615 0$aCell metabolism. 615 0$aEnergy metabolism. 676 $a572.431 701 $aSaks$b V. A$0866138 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144008403321 996 $aMolecular system bioenergetics$91933174 997 $aUNINA