LEADER 05418nam 2200685 450 001 9910144007703321 005 20170816120524.0 010 $a1-283-14037-3 010 $a9786613140371 010 $a3-527-62023-0 010 $a3-527-62030-3 035 $a(CKB)1000000000376042 035 $a(EBL)481471 035 $a(OCoLC)814511385 035 $a(SSID)ssj0000354689 035 $a(PQKBManifestationID)11251831 035 $a(PQKBTitleCode)TC0000354689 035 $a(PQKBWorkID)10313583 035 $a(PQKB)11345541 035 $a(MiAaPQ)EBC481471 035 $a(EXLCZ)991000000000376042 100 $a20160819h20082008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aProtein degradation$hVol. 4$iThe ubiquitin-proteasome system and disease /$fedited by R. John Mayer, Aaron Ciechanover, Martin Rechsteiner 210 1$aWeinheim, Germany :$cWILEY-VCH Verlag GmbH & Co. KGaA,$d2008. 210 4$dİ2008 215 $a1 online resource (260 p.) 225 1 $aProtein Degradation ;$vv.8 300 $aDescription based upon print version of record. 311 $a3-527-31436-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aProtein Degradation; Contents; Preface; List of Contributors; 1 Ubiquitin Signaling and Cancer Pathogenesis; 1.1 Introduction; 1.1.1 Ubiquitin Signaling Networks; 1.1.2 Ubiquitin-like Proteins; 1.2 Ubiquitin in Cancer Pathogenesis; 1.2.1 Ubiquitin in Cell Cycle Control; 1.2.2 Ubiquitin in the NF-?B Pathway; 1.2.3 Ubiquitin as a Signal in DNA Repair; 1.2.3.1 p53 Pathway; 1.2.3.2 BRCA1 and FANCD2; 1.2.3.3 PCNA and TLS Polymerases; 1.2.4 Ubiquitin Networks in Angiogenesis; 1.2.5 Ubiquitin Networks in Receptor Endocytosis; 1.3 Targeting Ubiquitin Networks in Cancers 327 $a1.3.1 Targeting Interactions between E3s and their Substrates1.3.2 Targeting the Proteasome; 1.3.3 Other Approaches; 1.4 Conclusions and Future Perspectives; 2 Regulation of the p53 Tumor-suppressor Protein by Ubiquitin and Ubiquitin-like Molecules; 2.1 Functional Domains of p53; 2.2 The Family of Ubiquitin-like Molecules; 2.3 E3 Ligases for p53; 2.4 Modification of p53 with Ubiquitin; 2.5 Requirements for Mdm2-mediated Ubiquitination of p53; 2.6 Regulation of p53 Ubiquitination; 2.6.1 E2 Conjugating Enzymes; 2.6.2 Interacting Proteins; 2.6.3 By Other Post-translational Modifications 327 $a2.7 De-ubiquitination of p532.8 SUMO-1/sentrin/smpt3; 2.9 NEDD8/Rub1; 2.10 Therapeutic Intervention through the Ubiquitin Pathway; 3 The Ubiquitin-Proteasome System in Epstein-Barr Virus Infection and Oncogenesis; 3.1 Introduction; 3.2 Viral Interference with the Ubiquitin-Proteasome System; 3.3 The EBV Life Cycle; 3.4 EBV and the Ubiquitin-Proteasome System; 3.4.1 EBNA1; 3.4.2 EBNA6 (EBNA3C); 3.4.3 LMP1; 3.4.4 LMP2; 3.4.5 BZLF1 (Zta) and BRLF1 (Rta); 3.4.6 BPLF1; 3.5 EBV-associated Malignancies; 3.6 Concluding Remarks; 4 HECT Ubiquitin-protein Ligases in Human Disease; 4.1 Introduction 327 $a4.2 Definition of HECT E3s4.3 Human HECT E3s and their Role in Disease; 4.4 E6-AP; 4.4.1 E6-AP and Cervical Cancer (Cancer of the Uterine Cervix); 4.4.2 E6-AP and Angelman Syndrome; 4.5 HECTH9; 4.6 HECT E3s with WW Domains; 4.6.1 Nedd4/Nedd4-2; 4.6.1.1 Nedd4/Nedd4-2 and Liddle's Syndrome; 4.6.1.2 Nedd4 and Retrovirus Budding; 4.6.2 Itch and the Immune Response; 4.6.3 Smurfs; 4.6.3.1 Smurfs and Cancer; 4.6.3.2 Smurfs and Bone Homeostasis; 4.7 Concluding Remarks; 5 Ubiquitin-independent Mechanisms of Substrate Recognition and Degradation by the Proteasome; 5.1 Introduction 327 $a5.2 Ubiquitin-independent Proteasome Substrates5.2.1 Ornithine Decarboxylase; 5.2.2 p21(Waf1/Cip1); 5.2.3 Retinoblastoma Protein; 5.2.4 p53 and p73; 5.2.5 Human Thymidylate Synthase; 5.2.6 Rpn4; 5.2.7 NF-?B and I?B?; 5.2.8 Steroid Receptor Co-activator-3; 5.2.9 c-Jun; 5.3 Mechanisms of Ubiquitin-independent Degradation; 5.4 Conclusion; 6 Endoplasmic Reticulum Protein Quality Control and Degradation; 6.1 Introduction; 6.2 ER-import, Folding and the Unfolded Protein Response; 6.3 General Principles and Components of ERQD (Endoplasmic Reticulum Quality Control and Protein Degradation) 327 $a6.4 Mechanism of ERQD 330 $aThis final volume in the series focuses on malfunctions of the ubiquitin-proteasome system and their role in human disease. The editors and authors represent unmatched expertise, comprising virtually all the top scientists in the field, including the pioneers of protein degradation research.From the contents:* Ubiquitin and cancer * Ubiquitin and liver cancer* Muscle atrophy* Aggresomes and human disease* Parkin and neurodegeneration* Chronic neurodegenerative diseases* Parkinson's disease* Ubiquitin and viruses* Druggability of the ubiquitin-proteas 410 0$aProtein Degradation 606 $aProteins$xMetabolism 606 $aUbiquitin 608 $aElectronic books. 615 0$aProteins$xMetabolism. 615 0$aUbiquitin. 676 $a572.76 676 $a612.3/98 702 $aMayer$b R. J. 702 $aCiechanover$b Aaron J. 702 $aRechsteiner$b Martin 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144007703321 996 $aProtein degradation$92074331 997 $aUNINA LEADER 02332nam 2200601Ia 450 001 9910784499003321 005 20230422044605.0 010 $a0-8166-9009-X 035 $a(CKB)1000000000346954 035 $a(EBL)310487 035 $a(OCoLC)476094755 035 $a(SSID)ssj0000242529 035 $a(PQKBManifestationID)11200148 035 $a(PQKBTitleCode)TC0000242529 035 $a(PQKBWorkID)10319727 035 $a(PQKB)10079730 035 $a(MiAaPQ)EBC310487 035 $a(Au-PeEL)EBL310487 035 $a(CaPaEBR)ebr10159648 035 $a(EXLCZ)991000000000346954 100 $a19990809d2000 ub 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aScreen style$b[electronic resource] $efashion and femininity in 1930s Hollywood /$fSarah Berry 210 $aMinneapolis $cUniversity of Minnesota Press$dc2000 215 $a1 online resource (260 p.) 225 1 $aCommerce and mass culture series ;$vv. 2 300 $aDescription based upon print version of record. 311 $a0-8166-3313-4 311 $a0-8166-3312-6 320 $aFilmography: p. 211-223. 320 $aIncludes bibliographical references (p. 191-209) and index. 327 $aCONTENTS; ACKNOWLEDGMENTS; INTRODUCTION; 1 CONSUMER FASHION AND CLASS; 2 STYLE AS SPECTACLE; 3 HOLLYWOOD EXOTICISM; 4 SUITABLY FEMININE; CONCLUSION; NOTES; FILMOGRAPHY; INDEX 330 $aRevealing the fascination of Hollywood movies in the thirties with strong-willed women-from the ambitions of gold-diggers, working girls, and social climbers to the illicit appeal of female androgyny and ethnic exoticism-Sarah Berry presents a lively, accessible, and lavishly illustrated look at 1930's films, fashions, fan magazines, and advertising. 410 0$aCommerce and mass culture series. 606 $aCostume 606 $aFashion in motion pictures 606 $aFashion$zUnited States$xHistory$y20th century 615 0$aCostume. 615 0$aFashion in motion pictures. 615 0$aFashion$xHistory 676 $a791.43/026 700 $aBerry$b Sarah$f1962-$01582270 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910784499003321 996 $aScreen style$93864508 997 $aUNINA