LEADER 04867nam 2200625Ia 450 001 9910144002403321 005 20170810192852.0 010 $a1-280-51958-4 010 $a9786610519583 010 $a3-527-60376-X 010 $a3-527-60418-9 035 $a(CKB)1000000000376073 035 $a(EBL)481672 035 $a(OCoLC)68623453 035 $a(SSID)ssj0000111697 035 $a(PQKBManifestationID)11141190 035 $a(PQKBTitleCode)TC0000111697 035 $a(PQKBWorkID)10081465 035 $a(PQKB)10865294 035 $a(MiAaPQ)EBC481672 035 $a(EXLCZ)991000000000376073 100 $a20040702d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBioelectronics$b[electronic resource] $efrom theory to applications /$fedited by Itamar Willner and Eugenii Katz 210 $aWeinheim ;$a[Great Britain] $cWiley-VCH$dc2005 215 $a1 online resource (495 p.) 300 $aDescription based upon print version of record. 311 $a3-527-30690-0 320 $aIncludes bibliographical references and index. 327 $aBioelectronics; Contents; Preface; List of Contributors; 1 Bioelectronics - An Introduction; References; 2 Electron Transfer Through Proteins; 2.1 Electronic Energy Landscapes; 2.2 Theory of Electron Tunneling; 2.3 Tunneling Pathways; 2.4 Coupling-limited ET Rates and Tests of the Pathway Model; 2.5 Multiple Tunneling Pathway Models; 2.6 Interprotein Electron Transfer: Docking and Tunneling; 2.7 Some New Directions in Electron Transfer Theory and Experiment; 2.8 Concluding Remarks; References 327 $a3 Reconstituted Redox Enzymes on Electrodes: From Fundamental Understanding of Electron Transfer at Functionalized Electrode Interfaces to Biosensor and Biofuel Cell Applications3.1 Introduction; 3.2 Electrodes Functionalized with Reconstituted Redox Proteins; 3.2.1 Reconstituted Flavoenzyme-Electrodes Using Molecular or Polymer Relay Systems; 3.2.2 Electrical Contacting of Flavoenzymes by Reconstitution on Carbon Nanotubes and Conducting Polymer Wires; 3.2.3 Electrical Contacting of Flavoenzymes by Means of Metallic Nanoparticles 327 $a3.2.4 Integrated Electrically Contacted Electrodes Composed of Reconstituted Quinoproteins3.2.5 Reconstituted Electrically Contacted Hemoproteins; 3.2.6 Reconstituted de novo Hemoproteins on Electrodes; 3.3 Electrical Contacting of Redox Proteins by Cross-linking of Cofactor-Enzyme Affinity Complexes on Surfaces; 3.3.1 Integrated NAD(P)(+)-Dependent Enzyme-Electrodes; 3.3.2 Integrated Electrically Contacted Hemoprotein Electrodes; 3.4 Reconstituted Enzyme-Electrodes for Biofuel Cell Design; 3.5 Conclusions and Perspectives; References 327 $a4 Application of Electrically Contacted Enzymes for Biosensors4.1 Introduction; 4.2 Biosensors - Precursors of Bioelectronics; 4.3 Via Miniaturization to Sensor Arrays - The Biochip; 4.4 The Route to Electrically Contacted Enzymes in Biosensors; 4.5 Routine Applications of Enzyme Electrodes; 4.6 Research Applications of Directly Contacted Proteins; 4.6.1 Protein Electrodes for the Detection of Oxygen-derived Radicals; 4.6.2 Cytochrome P 450 - An Enzyme Family Capable of Direct Electrical Communication; 4.7 Conclusions; References; 5 Electrochemical DNA Sensors; 5.1 Introduction 327 $a5.1.1 Indicator Electrodes5.1.2 Electrochemical Methods; 5.2 Natural Electroactivity and Labeling of Nucleic Acids; 5.2.1 Electroactivity of Nucleic Acid Components; 5.2.2 Analysis of Unlabeled Nucleic Acids; 5.2.3 Electroactive Labels of Nucleic Acids; 5.2.4 Signal Amplification; 5.3 Sensors for DNA and RNA Hybridization; 5.3.1 DNA Hybridization; 5.3.2 Electrochemical Detection in DNA Sensors; 5.3.3 Single-surface Techniques; 5.3.4 Double-surface Techniques; 5.3.5 Concluding Remarks to DNA Hybridization Sensors; 5.4 Sensors for DNA Damage; 5.4.1 DNA Damage 327 $a5.4.2 Relations Between DNA Damage and its Electrochemical Features 330 $aMedicine, chemistry, physics and engineering stand poised to benefit within the next few years from the ingenuity of complex biological structures invented and perfected by nature over millions of years.This book provides both researchers and engineers as well as students of all the natural sciences a vivid insight into the world of bioelectronics and nature's own nanotechnological treasure chamber. 606 $aBioelectronics 606 $aBiology 608 $aElectronic books. 615 0$aBioelectronics. 615 0$aBiology. 676 $a572.437 701 $aWillner$b Itamar$0945453 701 $aKatz$b Eugenii$0945454 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144002403321 996 $aBioelectronics$92134477 997 $aUNINA